ID Q54EK8_DICDI Unreviewed; 535 AA.
AC Q54EK8;
DT 24-MAY-2005, integrated into UniProtKB/TrEMBL.
DT 24-MAY-2005, sequence version 1.
DT 27-MAR-2024, entry version 107.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EAL61718.1};
GN ORFNames=DDB_G0291468 {ECO:0000313|EMBL:EAL61718.1};
OS Dictyostelium discoideum (Social amoeba).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689 {ECO:0000313|EMBL:EAL61718.1, ECO:0000313|Proteomes:UP000002195};
RN [1] {ECO:0000313|EMBL:EAL61718.1, ECO:0000313|Proteomes:UP000002195}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4 {ECO:0000313|EMBL:EAL61718.1,
RC ECO:0000313|Proteomes:UP000002195};
RX PubMed=15875012; DOI=10.1038/nature03481;
RG The Dictyostelium discoideum Sequencing Consortium;
RA Eichinger L., Pachebat J.A., Glockner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M., Spiegler S., Tivey A., Sugano S.,
RA White B., Walker D., Woodward J., Winckler T., Tanaka Y., Shaulsky G.,
RA Schleicher M., Weinstock G., Rosenthal A., Cox E.C., Chisholm R.L.,
RA Gibbs R., Loomis W.F., Platzer M., Kay R.R., Williams J., Dear P.H.,
RA Noegel A.A., Barrell B., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Acts as a molecular chaperone for G protein-coupled
CC receptors, regulating their biogenesis and exit from the ER.
CC {ECO:0000256|ARBA:ARBA00037107}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004586}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAL61718.1}.
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DR EMBL; AAFI02000177; EAL61718.1; -; Genomic_DNA.
DR RefSeq; XP_635232.1; XM_630140.1.
DR AlphaFoldDB; Q54EK8; -.
DR SMR; Q54EK8; -.
DR STRING; 44689.Q54EK8; -.
DR PaxDb; 44689-DDB0183912; -.
DR GeneID; 8628178; -.
DR KEGG; ddi:DDB_G0291468; -.
DR dictyBase; DDB_G0291468; -.
DR eggNOG; KOG0522; Eukaryota.
DR HOGENOM; CLU_026137_1_0_1; -.
DR InParanoid; Q54EK8; -.
DR OMA; YPMHQSV; -.
DR PhylomeDB; Q54EK8; -.
DR PRO; PR:Q54EK8; -.
DR Proteomes; UP000002195; Chromosome 6.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR021832; ANKRD13.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR PANTHER; PTHR12447; ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 13; 1.
DR PANTHER; PTHR12447:SF25; ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 13C; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF11904; GPCR_chapero_1; 1.
DR SMART; SM00248; ANK; 2.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Chaperone {ECO:0000256|ARBA:ARBA00023186};
KW Reference proteome {ECO:0000313|Proteomes:UP000002195}.
FT REPEAT 74..106
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 303..365
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..24
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 321..365
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 535 AA; 61922 MW; CE4C1F29826EE850 CRC64;
MNFFKSNSNS NSDTSSSSSN NTSNDIKPEK KDYKHIDDPF RIHRLTCENN IEEIKKYLDS
EPYYKEFIDI RDTHGYSASH YAAHFGHKNI IELLLKYGAD PTKKSAAGWS VIQEACGRKD
REIVTLLLQQ IKNKIENEFT KRMPILVSAL ENIPDFEMEL KWEVKSWVPL VTRFCPYDTY
KIYKQGSSFR VDTSIIGMDG IKFIRGDLSF LYKSQRLFSM DNIKHTYSEM EIVASKNPKV
HDEEVDILLD QTMNRVKLMT DEIVFTKSKT WFGNEKTEKI GDNADWNAKM FDVTNVDLKI
MARKPKRQPN HPHFNKDQQQ LEGKDSSSSG SDDDDNNNNN NNNKITTNID DNNNNNDEDE
LNQNPIEQTK KYIESLKNVT YEIRDSTLKS KIMEPGYFKA PKNFDPYTHE QNINKSKIKT
QGLLCDGETV SERHKYFKGT IWISEEFPRK VTDLLPIFEV LSPTNKLFSR LCEFISLKLP
SDGFPVKLDL PLFPTISATV IFTKYIEKPV DKNLFTIPSH YIVKTTPPSS TTFTK
//
