ID HBX3_DICDI Reviewed; 667 AA.
AC Q54F11;
DT 24-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 24-JAN-2024, entry version 110.
DE RecName: Full=Homeobox protein 3;
DE Short=DdHbx-3;
GN Name=hbx3; ORFNames=DDB_G0291197;
OS Dictyostelium discoideum (Social amoeba).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP INDUCTION [LARGE SCALE ANALYSIS].
RX PubMed=18559084; DOI=10.1186/1471-2164-9-291;
RA Sillo A., Bloomfield G., Balest A., Balbo A., Pergolizzi B., Peracino B.,
RA Skelton J., Ivens A., Bozzaro S.;
RT "Genome-wide transcriptional changes induced by phagocytosis or growth on
RT bacteria in Dictyostelium.";
RL BMC Genomics 9:291-291(2008).
CC -!- FUNCTION: Putative transcription factor. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- INDUCTION: Up-regulated by phagocytic stimuli.
CC {ECO:0000269|PubMed:18559084}.
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DR EMBL; AAFI02000175; EAL61882.1; -; Genomic_DNA.
DR RefSeq; XP_635379.1; XM_630287.1.
DR AlphaFoldDB; Q54F11; -.
DR STRING; 44689.Q54F11; -.
DR PaxDb; 44689-DDB0220480; -.
DR EnsemblProtists; EAL61882; EAL61882; DDB_G0291197.
DR GeneID; 8628027; -.
DR KEGG; ddi:DDB_G0291197; -.
DR dictyBase; DDB_G0291197; hbx3.
DR eggNOG; KOG0774; Eukaryota.
DR HOGENOM; CLU_411872_0_0_1; -.
DR InParanoid; Q54F11; -.
DR OMA; LMEDENC; -.
DR PRO; PR:Q54F11; -.
DR Proteomes; UP000002195; Chromosome 5.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0048468; P:cell development; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR008422; Homeobox_KN_domain.
DR PANTHER; PTHR11211:SF3; HOMEOBOX PROTEIN MOHAWK; 1.
DR PANTHER; PTHR11211; IROQUOIS-CLASS HOMEODOMAIN PROTEIN IRX; 1.
DR Pfam; PF05920; Homeobox_KN; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Developmental protein; DNA-binding; Homeobox; Nucleus;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..667
FT /note="Homeobox protein 3"
FT /id="PRO_0000388787"
FT DNA_BIND 602..664
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 44..108
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 179..232
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 249..268
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 331..418
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 386..454
FT /evidence="ECO:0000255"
FT COMPBIAS 62..108
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 342..394
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 395..418
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 667 AA; 77384 MW; 402AC5022683936B CRC64;
MIVDYQDVDT VISGVDYFSS YNGNIENENC KLSDLFEQNV NNQFFQPNNT SLPPPTNQQP
QPQPQQWDLM EDENCNSSFE NSPQQPTSPL LISSQTSYPS DLSSNSSISH SPIENQLLDN
NLDINNYLNK INIFNNHFQN SDLINTTFFN QFENNNYINN NNNKENNSYF YNNNVNIPNN
NNLNINNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNKNTV YNNVNIPNNN
NFNLNLSNNN NNLNLTNNNN NKNSVNNNNV NISNNNNNNN FNVNLSNNNV NISNIPISNY
YQQAAQTIFD DNFQTIQFNK EYPLNEHISQ STNKRMKISH HSHSLSNNNE NSLSQPYFNN
NNNNNNENEN VYNIVNEQNP TFNPNQSNTH QQQEEQYQQH EEGQEEKEHE EEEKYQKQKP
KIEIEELINI NLIKEKIEKL KNKFENENVI CSEFLEKCFK FSSFPIFPIV ESKLKFYQFE
IDFSFSSYIE SQKLDKIGLP SFKRPVQFLN TFYTQEIVNL DQELITRSQP IHDFIECISL
IRPLLSLSSS SSSSSSSSSP SSSNELNSKL NMVQSVFNVV KSYQKTNTAN VILQVLKKYA
KEFKSRRILS EQQETNMNLW FDAHVNNPYP EEDEKVILGA VNNLSKSQID NWFGNKRMRD
KSNKKSL
//
