ID Q54H47_DICDI Unreviewed; 356 AA.
AC Q54H47;
DT 24-MAY-2005, integrated into UniProtKB/TrEMBL.
DT 24-MAY-2005, sequence version 1.
DT 27-MAR-2024, entry version 91.
DE SubName: Full=Transmembrane protein {ECO:0000313|EMBL:EAL62565.1};
GN ORFNames=DDB_G0289707 {ECO:0000313|EMBL:EAL62565.1};
OS Dictyostelium discoideum (Social amoeba).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689 {ECO:0000313|EMBL:EAL62565.1, ECO:0000313|Proteomes:UP000002195};
RN [1] {ECO:0000313|EMBL:EAL62565.1, ECO:0000313|Proteomes:UP000002195}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4 {ECO:0000313|EMBL:EAL62565.1,
RC ECO:0000313|Proteomes:UP000002195};
RX PubMed=15875012; DOI=10.1038/nature03481;
RG The Dictyostelium discoideum Sequencing Consortium;
RA Eichinger L., Pachebat J.A., Glockner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M., Spiegler S., Tivey A., Sugano S.,
RA White B., Walker D., Woodward J., Winckler T., Tanaka Y., Shaulsky G.,
RA Schleicher M., Weinstock G., Rosenthal A., Cox E.C., Chisholm R.L.,
RA Gibbs R., Loomis W.F., Platzer M., Kay R.R., Williams J., Dear P.H.,
RA Noegel A.A., Barrell B., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CCC1 family.
CC {ECO:0000256|ARBA:ARBA00007049}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAL62565.1}.
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DR EMBL; AAFI02000148; EAL62565.1; -; Genomic_DNA.
DR RefSeq; XP_636071.1; XM_630979.1.
DR AlphaFoldDB; Q54H47; -.
DR SMR; Q54H47; -.
DR STRING; 44689.Q54H47; -.
DR PaxDb; 44689-DDB0304398; -.
DR GeneID; 8627281; -.
DR KEGG; ddi:DDB_G0289707; -.
DR dictyBase; DDB_G0289707; -.
DR eggNOG; KOG4473; Eukaryota.
DR HOGENOM; CLU_038957_2_0_1; -.
DR InParanoid; Q54H47; -.
DR OMA; EADHYHT; -.
DR PhylomeDB; Q54H47; -.
DR Proteomes; UP000002195; Chromosome 5.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005381; F:iron ion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005384; F:manganese ion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0030026; P:intracellular manganese ion homeostasis; IBA:GO_Central.
DR GO; GO:0006880; P:intracellular sequestering of iron ion; IBA:GO_Central.
DR CDD; cd02434; Nodulin-21_like_3; 1.
DR InterPro; IPR008217; Ccc1_fam.
DR PANTHER; PTHR31851:SF10; -; 1.
DR PANTHER; PTHR31851; FE(2+)/MN(2+) TRANSPORTER PCL1; 1.
DR Pfam; PF01988; VIT1; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002195};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 121..142
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 148..172
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 262..285
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 291..311
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 323..349
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 31..88
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 62..88
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 356 AA; 39785 MW; 34326137BF8B2045 CRC64;
MSSKAYNRLN INESIENNEN ENENEIYREN EDLNNNNNNN DENKNESDND NDNDNNNDNN
DDDDNNNINN GIINNNNKNN NNNENNNENN EIERSQIILQ PIIRKPKIEK KQSFLSKYLK
SIIYGGMDGL VSIFVSIAVS FSSSDAKISV LLIIVLSKLV AGAISMGMGD YLGTQADIDF
ARGERKREAW EVEYYLEGEK SEMVEIYTKK GIPEEVAREV VDILSLNPKG FVDVMMVEEL
GIMPDVESQT PWKNGLVNFT SFVFFGILPL LPYLAFLAIA TVAKIPSDQH LYLFLIVIGI
TALTLFLIGI FKAKSTDTKW YKSGATTVIF GVIGAAAGLG TVELIKVIFP NVDISQ
//
