ID Q54HF4_DICDI Unreviewed; 1677 AA.
AC Q54HF4;
DT 24-MAY-2005, integrated into UniProtKB/TrEMBL.
DT 24-MAY-2005, sequence version 1.
DT 27-MAR-2024, entry version 105.
DE RecName: Full=RNA uridylyltransferase {ECO:0000256|ARBA:ARBA00012472};
DE EC=2.7.7.52 {ECO:0000256|ARBA:ARBA00012472};
GN ORFNames=DDB_G0289529 {ECO:0000313|EMBL:EAL62696.1};
OS Dictyostelium discoideum (Social amoeba).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689 {ECO:0000313|EMBL:EAL62696.1, ECO:0000313|Proteomes:UP000002195};
RN [1] {ECO:0000313|EMBL:EAL62696.1, ECO:0000313|Proteomes:UP000002195}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4 {ECO:0000313|EMBL:EAL62696.1,
RC ECO:0000313|Proteomes:UP000002195};
RX PubMed=15875012; DOI=10.1038/nature03481;
RG The Dictyostelium discoideum Sequencing Consortium;
RA Eichinger L., Pachebat J.A., Glockner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M., Spiegler S., Tivey A., Sugano S.,
RA White B., Walker D., Woodward J., Winckler T., Tanaka Y., Shaulsky G.,
RA Schleicher M., Weinstock G., Rosenthal A., Cox E.C., Chisholm R.L.,
RA Gibbs R., Loomis W.F., Platzer M., Kay R.R., Williams J., Dear P.H.,
RA Noegel A.A., Barrell B., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=RNA(n) + UTP = diphosphate + RNA(n)-3'-uridine ribonucleotide;
CC Xref=Rhea:RHEA:14785, Rhea:RHEA-COMP:14527, Rhea:RHEA-COMP:17348,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:46398, ChEBI:CHEBI:140395,
CC ChEBI:CHEBI:173116; EC=2.7.7.52;
CC Evidence={ECO:0000256|ARBA:ARBA00024498};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAL62696.1}.
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DR EMBL; AAFI02000141; EAL62696.1; -; Genomic_DNA.
DR RefSeq; XP_636183.1; XM_631091.1.
DR AlphaFoldDB; Q54HF4; -.
DR SMR; Q54HF4; -.
DR STRING; 44689.Q54HF4; -.
DR PaxDb; 44689-DDB0219440; -.
DR GeneID; 8627170; -.
DR KEGG; ddi:DDB_G0289529; -.
DR dictyBase; DDB_G0289529; -.
DR eggNOG; KOG1802; Eukaryota.
DR eggNOG; KOG2277; Eukaryota.
DR HOGENOM; CLU_241622_0_0_1; -.
DR InParanoid; Q54HF4; -.
DR PhylomeDB; Q54HF4; -.
DR Proteomes; UP000002195; Chromosome 5.
DR GO; GO:0016604; C:nuclear body; IBA:GO_Central.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:InterPro.
DR GO; GO:0016779; F:nucleotidyltransferase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0001147; F:transcription termination site sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006369; P:termination of RNA polymerase II transcription; IBA:GO_Central.
DR CDD; cd18042; DEXXQc_SETX; 1.
DR CDD; cd05402; NT_PAP_TUTase; 1.
DR CDD; cd18808; SF1_C_Upf1; 1.
DR Gene3D; 1.10.1410.10; -; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR045055; DNA2/NAM7-like.
DR InterPro; IPR041679; DNA2/NAM7-like_C.
DR InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047187; SF1_C_Upf1.
DR InterPro; IPR045100; TUTase_dom.
DR PANTHER; PTHR10887; DNA2/NAM7 HELICASE FAMILY; 1.
DR PANTHER; PTHR10887:SF525; HELICASE SENATAXIN-RELATED; 1.
DR Pfam; PF13086; AAA_11; 1.
DR Pfam; PF13087; AAA_12; 1.
DR Pfam; PF19088; TUTase; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF81631; PAP/OAS1 substrate-binding domain; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000002195}.
FT DOMAIN 1207..1385
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 203..266
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1601..1677
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 761..788
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 203..238
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 239..261
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1645..1668
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1677 AA; 191842 MW; 0C193285870601CE CRC64;
MSQRNNIFEL VFKEIDINDQ IQVIDSFKNQ FKGNEIELNL MKDFVKKSKS RRDGLLGKLL
HSLKAMLKNQ SNESIKSSIF YNQYLVLRMV IEFNFFCQRK YLKEHCKAYG LNFSKCSAIL
ESVQSRFGIK KIFTRNLSEF SKPIEIIDGA SIYFEIPNFS LPFDGGNIIM TIKNLFEEVR
LLKETSLATG ILKQVPDVIK ITQTQSQPQT QTQKPTSNSN SNSNSNTLNN NNNYNNNNDN
DNDDDDDDDD DDDDDDENND EITIFNNIYK EFNENKTESR KNIGDDYPIK LFEAFRKEQP
TEEGYHSNDF KKNILNMAYY LKEYIPDFYL NYQIPKHQKA ITHDLIILFN KIKCKRVSKK
EKSFNRLEMF LSNKFKDSSI QLYGSFLTGL SLEGSDLDVN FKINQNENQV THLEVVSKYL
ESTKLYTIIE KRLSATVPII RFVEKSSKYH FDMSCNSSKA YFNSLLLKEY CSIDNRYIIL
SLLVKWWASC KNLNDASKHT FSSFCLVNMV IHFLQSISTP ILPNLQTKSP QLLNSYSTNP
ILKRIDSFEF YEFKSFDKFD SSKNKLKIDQ LFYLFFNYYS IFNYKENIIS ISHSSGGGTL
CKNGPLLKRS SLVNEDLLKS TMIVLDPFVT DRNIASSIQN SFFRIIVEFI HMENSIRLKK
FKDINELFKD ISLPKLVPLL PTPSLNTTTT TNQVVPTLTT TPAAVPTSIP ATIALPKLDM
ITTPKQTLSN PIASTIDIEK SLKNSLLMKI FEDPKSVLFI LNELNKLLKN ENNNQNKLNK
LKRIIEEDTK SFEQQINNCN RTLNQLIPSE NLSRKSSVNL IYQKTLTLMA LIEFNHHYQN
IELRNLTKGN RTTFNDLKSE LAKNKIKFDP RCLEKSKVTM IQDFQSKISP IIKIPNFQLN
ESERLETVLE LLFIEIHQLF KNETISVHSI GTKKSNNNDN NNNNTKIKAD YIYSYVDVIS
ISPDETLNLI LSCEPSKIPL LKPNGIGELS DNYTGEKEYQ IVNKPLIFDD FRAQVENGIN
ALNGINSAKD GTFEGFDKIK MNEAIEVVQI SRQTKFITVE LIIHGNRNKL EEISVGDILL
FKVIGLDGTK FTFGIVRKTS NLMQGSLHQQ SIVCDLLYSN PTHFFTKSLN SSTQSSIHYN
KISNSVTFIR SIQEFKASPF IKNLIFNPGC NNNLNQKMMK FPPTLETICK EKLNESQLNA
IKSSLVESGI TLIQGPPGTG KTTTINYLLS VLLAIDKKFK ILVCGPSHAS VDEVAKRCLK
NLLNSDGQIF KPNMVRTGRK EKISPECQKI SLKNKNSSRR INLIKSASIV FSTLAGSGSK
AIFENFSPDI VLIDESTQSS EPTSIIPLSL GSVKKLILVG DPVQLPPTIF SKQGADCGLK
ISLFERLAKS IDVQFLNTQY RMHPVTSKFI SEEFYNGTLK DGENVSIDSY NNCKFHFDPS
FGPMKFFDLP KSNQKVIKKS IMNQDEIDKV FTLIKELIEK YPECKKLSFG IITPYKLQMN
QIKEQLNRSE HHNLNISVST IDGVQGSEKD IIIMSCVRSI EKFGIGFLSD RRRINVALTR
AKLGLYVIGT YKVLAKDNTW EKFLIHTTID FDHIYKSNQI NNNSNQSIQN SDQDNNKDNH
DDNNDDSDEQ SEDEFFVVPK GGNDEEDDFY DEEMDNNDDD EMDNNDDDEM GNNNQKK
//
