GenomeNet

Database: UniProt
Entry: Q54IV4
LinkDB: Q54IV4
Original site: Q54IV4 
ID   Y8495_DICDI             Reviewed;         532 AA.
AC   Q54IV4;
DT   24-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   23-MAY-2018, entry version 53.
DE   RecName: Full=SET and MYND domain-containing protein DDB_G0288495;
DE            EC=2.1.1.-;
GN   ORFNames=DDB_G0288495;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Mycetozoa; Dictyostelids; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A.,
RA   Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q.,
RA   Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F.,
RA   Bankier A.T., Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P.,
RA   Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P.,
RA   Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N.,
RA   Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M.,
RA   Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I.,
RA   Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R.,
RA   Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C.,
RA   Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D.,
RA   Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S.,
RA   Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T.,
RA   Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A.,
RA   Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M.,
RA   Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G.,
RA   Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
RN   [2]
RP   INDUCTION [LARGE SCALE ANALYSIS].
RX   PubMed=18590548; DOI=10.1186/1471-2180-8-109;
RA   Carilla-Latorre S., Calvo-Garrido J., Bloomfield G., Skelton J.,
RA   Kay R.R., Ivens A., Martinez J.L., Escalante R.;
RT   "Dictyostelium transcriptional responses to Pseudomonas aeruginosa:
RT   common and specific effects from PAO1 and PA14 strains.";
RL   BMC Microbiol. 8:109-109(2008).
RN   [3]
RP   INDUCTION [LARGE SCALE ANALYSIS].
RX   PubMed=18559084; DOI=10.1186/1471-2164-9-291;
RA   Sillo A., Bloomfield G., Balest A., Balbo A., Pergolizzi B.,
RA   Peracino B., Skelton J., Ivens A., Bozzaro S.;
RT   "Genome-wide transcriptional changes induced by phagocytosis or growth
RT   on bacteria in Dictyostelium.";
RL   BMC Genomics 9:291-291(2008).
CC   -!- FUNCTION: Probable methyltransferase. {ECO:0000250}.
CC   -!- INDUCTION: Down-regulated by phagocytic stimuli and up-regulated
CC       by Pseudomonas aeruginosa, PAO1 strain and PA14 strain infection.
CC       {ECO:0000269|PubMed:18559084, ECO:0000269|PubMed:18590548}.
CC   -!- SIMILARITY: Belongs to the class V-like SAM-binding
CC       methyltransferase superfamily. {ECO:0000255|PROSITE-
CC       ProRule:PRU00190}.
DR   EMBL; AAFI02000112; EAL63196.1; -; Genomic_DNA.
DR   RefSeq; XP_636699.1; XM_631607.1.
DR   PaxDb; Q54IV4; -.
DR   PRIDE; Q54IV4; -.
DR   EnsemblProtists; EAL63196; EAL63196; DDB_G0288495.
DR   GeneID; 8626656; -.
DR   KEGG; ddi:DDB_G0288495; -.
DR   dictyBase; DDB_G0288495; smdA.
DR   InParanoid; Q54IV4; -.
DR   OMA; ELECKWI; -.
DR   PRO; PR:Q54IV4; -.
DR   Proteomes; UP000002195; Chromosome 5.
DR   Proteomes; UP000002195; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:1901261; P:regulation of sorocarp spore cell differentiation; IMP:dictyBase.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR002893; Znf_MYND.
DR   Pfam; PF00856; SET; 1.
DR   SMART; SM00317; SET; 1.
DR   PROSITE; PS50280; SET; 1.
DR   PROSITE; PS01360; ZF_MYND_1; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Complete proteome; Metal-binding; Methyltransferase;
KW   Reference proteome; S-adenosyl-L-methionine; Transferase; Zinc;
KW   Zinc-finger.
FT   CHAIN         1    532       SET and MYND domain-containing protein
FT                                DDB_G0288495.
FT                                /FTId=PRO_0000389434.
FT   DOMAIN       25    448       SET. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00190}.
FT   ZN_FING      70    116       MYND-type; degenerate.
FT   COILED      199    240       {ECO:0000255}.
FT   COMPBIAS    173    176       Poly-Asn.
FT   COMPBIAS    206    218       Poly-Glu.
FT   COMPBIAS    356    361       Poly-Asp.
FT   COMPBIAS    362    365       Poly-Asn.
FT   COMPBIAS    407    419       Poly-Asn.
SQ   SEQUENCE   532 AA;  62080 MW;  2C4B51E2C5C78F54 CRC64;
     MISYEYCDSS DSFYFNDIQD FDFNPWIEVK SVSEKGRCVF SKKFIPKGTM VFRDIPYAAI
     VDNQFKRNIC TTCFKILLES NRHNFQTCPS CFQVNYCSNY CKQYSKIETK HTELECKWIQ
     DFTVSFKHQM AEDDRNIVLL VLKILARRIH EKQSTIFHNK PLTTNTFETC TSNNNNIDLL
     PMIPNDIPDL IDHLDDYFIN SKNNNEFENE EEEEEEQEQK GEGEQEENEN NENNEKVKKK
     VIIIDDNEKE KEEIKKFNKI WKNDFKRLIN IAKVIQIIID DSIDSLENIK CDYGFVDNQG
     DTEMVDNSID PKGLDKLVDN LSSSDLNILR LLCKIRANYF GLWNSAYKPI PLNSIDDDDD
     DNNNNKEKPN NDYLWCGSGV YLKLSLFNHS CFPNCTTLIE YNINKKNSNN NNGNNGNNNS
     YGDTNQLTIS IITLRDIEEN QELLITYIPL NQKINDRVKS LKSNWLFQCD CKRCHFEKIN
     ENQTEKIYKD SCCTNQKCSG GLLIPLEQNS TQGICRVCKN TYTLPTVFYP LK
//
DBGET integrated database retrieval system