GenomeNet

Database: UniProt
Entry: Q54KF7
LinkDB: Q54KF7
Original site: Q54KF7 
ID   SIBA_DICDI              Reviewed;        1927 AA.
AC   Q54KF7; Q0PL85; Q23848;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   04-DEC-2007, sequence version 2.
DT   07-NOV-2018, entry version 91.
DE   RecName: Full=Integrin beta-like protein A;
DE   AltName: Full=109 gene 1 protein;
DE   Flags: Precursor;
GN   Name=sibA; ORFNames=DDB_G0287363;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Mycetozoa; Dictyostelids; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A.,
RA   Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q.,
RA   Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F.,
RA   Bankier A.T., Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P.,
RA   Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P.,
RA   Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N.,
RA   Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M.,
RA   Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I.,
RA   Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R.,
RA   Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C.,
RA   Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D.,
RA   Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S.,
RA   Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T.,
RA   Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A.,
RA   Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M.,
RA   Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G.,
RA   Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 1-48, FUNCTION, AND INTERACTION WITH
RP   TALA.
RX   PubMed=16699495; DOI=10.1038/sj.embor.7400701;
RA   Cornillon S., Gebbie L., Benghezal M., Nair P., Keller S.,
RA   Wehrle-Haller B., Charette S.J., Brueckert F., Letourneur F.,
RA   Cosson P.;
RT   "An adhesion molecule in free-living Dictyostelium amoebae with
RT   integrin beta features.";
RL   EMBO Rep. 7:617-621(2006).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1781-1927.
RC   STRAIN=AX3;
RX   PubMed=2926809; DOI=10.1016/0022-2836(89)90364-1;
RA   Giorda R., Ohmachi T., Ennis H.L.;
RT   "Organization of a gene family developmentally regulated during
RT   Dictyostelium discoideum spore germination.";
RL   J. Mol. Biol. 205:63-69(1989).
RN   [4]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=16512674; DOI=10.1021/pr050350q;
RA   Reinders Y., Schulz I., Graef R., Sickmann A.;
RT   "Identification of novel centrosomal proteins in Dictyostelium
RT   discoideum by comparative proteomic approaches.";
RL   J. Proteome Res. 5:589-598(2006).
CC   -!- FUNCTION: Implicated in cellular adhesion to substrate or
CC       phagocytic particles. {ECO:0000269|PubMed:16699495}.
CC   -!- SUBUNIT: Interacts with talA/talin. {ECO:0000269|PubMed:16699495}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the SIB family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAL63749.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
DR   EMBL; AAFI02000100; EAL63749.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; DQ793219; ABG81508.1; -; mRNA.
DR   EMBL; M19467; AAA67431.1; -; Genomic_DNA.
DR   RefSeq; XP_637266.1; XM_632174.1.
DR   IntAct; Q54KF7; 1.
DR   MINT; Q54KF7; -.
DR   STRING; 44689.DDB0233521; -.
DR   TCDB; 8.A.74.1.1; the tm9 or phg1 targeting receptor (ppg1) family.
DR   PaxDb; Q54KF7; -.
DR   PRIDE; Q54KF7; -.
DR   EnsemblProtists; EAL63749; EAL63749; DDB_G0287363.
DR   GeneID; 8626097; -.
DR   KEGG; ddi:DDB_G0287363; -.
DR   dictyBase; DDB_G0287363; sibA.
DR   eggNOG; ENOG410JKUI; Eukaryota.
DR   eggNOG; ENOG410ZNM0; LUCA.
DR   InParanoid; Q54KF7; -.
DR   PhylomeDB; Q54KF7; -.
DR   PRO; PR:Q54KF7; -.
DR   Proteomes; UP000002195; Chromosome 5.
DR   Proteomes; UP000002195; Unassembled WGS sequence.
DR   GO; GO:0009986; C:cell surface; IDA:dictyBase.
DR   GO; GO:0005769; C:early endosome; IDA:dictyBase.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IDA:dictyBase.
DR   GO; GO:0055037; C:recycling endosome; IDA:dictyBase.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0031589; P:cell-substrate adhesion; IMP:dictyBase.
DR   GO; GO:0006909; P:phagocytosis; IMP:dictyBase.
DR   CDD; cd00064; FU; 1.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR015919; Cadherin-like_sf.
DR   InterPro; IPR013032; EGF-like_CS.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR006212; Furin_repeat.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   SUPFAM; SSF49313; SSF49313; 1.
DR   SUPFAM; SSF53300; SSF53300; 1.
DR   PROSITE; PS00022; EGF_1; 1.
DR   PROSITE; PS01186; EGF_2; 2.
DR   PROSITE; PS50026; EGF_3; 1.
DR   PROSITE; PS50234; VWFA; 1.
PE   1: Evidence at protein level;
KW   Cell adhesion; Complete proteome; Disulfide bond; EGF-like domain;
KW   Glycoprotein; Membrane; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL        1     20       {ECO:0000255}.
FT   CHAIN        21   1927       Integrin beta-like protein A.
FT                                /FTId=PRO_0000312331.
FT   TOPO_DOM     21   1860       Extracellular. {ECO:0000255}.
FT   TRANSMEM   1861   1881       Helical. {ECO:0000255}.
FT   TOPO_DOM   1882   1927       Cytoplasmic. {ECO:0000255}.
FT   DOMAIN      425    462       EGF-like. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   DOMAIN      522    709       VWFA. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00219}.
FT   COMPBIAS    979    984       Poly-Ser.
FT   CARBOHYD    309    309       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   1122   1122       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   1516   1516       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   1717   1717       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   1723   1723       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   1855   1855       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   DISULFID    435    450       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    452    461       {ECO:0000255|PROSITE-ProRule:PRU00076}.
SQ   SEQUENCE   1927 AA;  208361 MW;  AD03CAB03B1A6D35 CRC64;
     MNRILTLFIL FISLFIVCEA THFRFGTMSW MPMGSHNTIK FSSNYAFRIG FFKKFNKGCN
     VGDVVKVGDL DLGDDKTKVD VNLVVTSVNQ ADDWFTGEFS YTHTYNPIKL GGKAVTYKVV
     FTDCCRIKSL LNNAEGSWYI STSVVVDPNQ GSDVSTFNRS PVSGMVPIIT LNRDKNNQFL
     IAASDPNGDT LTYSLSNAYT MNQPSGLSID SSKGIVSFKP TVSGFYSTQI MIKDTKGAYV
     VVDFLINSVI EPGVCHPSCS NGGNTCNGNS GCKSCKGTDS NGNTCSSFPP VFVYPPTPTD
     GSLLAYEVNK TNSFSIQCKT EEKSKTVFIQ PANIPLAATL TSSDQNKQVS TLTYSMLPQL
     KHIGVYVISA YCTDNKGLVS TITSFSISVE KPICGHGTNK PGGGCNCETG WDPEKNCYEC
     LKGHYGEKCD PVDPCVNGES NEGSQGNGKC TCYYGWEGKN CDIKVNQVCN ANKENVVLDS
     SVAKSSYINP NFAQVYLNTD PSKQALTLSS KLSIPETIDK FEVLVLVDSQ PSIVEYWDNF
     KKYSSDLTKN LQDISETVSI GLGLFSDAKT NGYSFVLKKS IGNGLSGLDD KDKAPASSYS
     TKNSLIALTS AAEFPAGWST GSIKIIVLLT DNDYSATAQE VSKFTSTLIS KSILPVVVSF
     NDNQNWDTLF KNQGFGSTKK TSNAKGNDWV SVATSAIKDV LSKAVVKAID DTKGFLTLPS
     ATTISIEDSK DYTIPIQIKY PQGQSDIPQN PSVSYSVVGF GITRIVINYN SAPTALGYSI
     ETKQNVNYNF KLSGSDVDGN TLTIKFKTIP AASVGVIQAD GVTIEQGDSF SIEKTFTFKP
     ATNYYTKSTN DKFTFVANDG CLDSNEATVE IKITHVNQAP SCSSLSGSAI SVTGLNTPKS
     FSLQGSDIET DSNLKIVFGD LTAISAYGNI KSGSNVVSTG SSVQLSSGSA SLTFTQTKDI
     ANDKEITVDF KVNDGSLDSS SSCSFKVKFV HFNKPPVAFA VTPLTIRQNS ELKITISASD
     SDSDSVIFTL DDLKLGGGDS FFKCDDRSQL TAPFTTQPVS ISGGVASFSE ICYSSPLVNA
     NSYASLVFFA NDGQLSSDKF KVLININGDR PNAPPVVNQI PNFTMNEDDI SNELVIDGID
     PDELDQGKLK GIIIQKPTNG VILVKSGSST SEAPIIGNAP YKIFYKPNPL YYGTDSFSYT
     VEDSMGERDA TPKTTQITVQ HVNHAPTLSI DPYDFTSQTS EKTLELTPKD IDLIDTVFHC
     TIVKLPATAI IKTSAGKVID TVPTDLSDNK YIITSNNNIY NDFSDSFDAK CYDSSNAVSN
     IATGPITFRY INVPPKAESS DETLNQDSSV SFSVKATDLE DNSNVRAVIR SLPAKGTLTI
     KSTGKAAEIS STYAIDDFVY TPVAGYSNWD KPGHVGPADS FNFVAKDSKN DISSNIGTVS
     FFIEPRNPPT YEGLAVLYTK ENTDLPFSIS GIVGNGGSNV FLRIKSIVSR GSLYATHCMG
     TEGCMSEPNP VDININFTSQ PYTFSFTPIE YENGDNYAII EFVLYDKFNG QEVESQKYTI
     IINVIPVNQA PEVILIEHTL STLPNNVIAF DKFKTVKMET NSYVIIKYDG TDIDDPKEKL
     KSYIVSPPLR GLLYVYDKDA KDGLGKLIKK DDTFVPVAQD GFWYIVFVPT PGSSGDGYVR
     IPISMVDFLG DISVPVTVAV DVSKKNIPPF ITIENKNYTS LANTSIVVTG VSFDDPDSKY
     NDVELILSLV NKDGDLVSNK IATFSLSQQS KAKCTKHSEF AQFTCRSNKK TLNALISTMY
     VNHQGGGSYR LKVFVNDLGY SSPASIRDKN HMTATDYVEL DVTKPEVTTT KENNNKTVLT
     GAIAGAAAGA GLLAAGAWFL LKKSAPPTDA FFGEGAFADG AVSTNPMYEE SGRSAINPLY
     EASSENL
//
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