ID Q54KQ4_DICDI Unreviewed; 1872 AA.
AC Q54KQ4;
DT 24-MAY-2005, integrated into UniProtKB/TrEMBL.
DT 24-MAY-2005, sequence version 1.
DT 27-MAR-2024, entry version 128.
DE SubName: Full=SNF2-related domain-containing protein {ECO:0000313|EMBL:EAL63860.1};
GN ORFNames=DDB_G0287171 {ECO:0000313|EMBL:EAL63860.1};
OS Dictyostelium discoideum (Social amoeba).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689 {ECO:0000313|EMBL:EAL63860.1, ECO:0000313|Proteomes:UP000002195};
RN [1] {ECO:0000313|EMBL:EAL63860.1, ECO:0000313|Proteomes:UP000002195}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4 {ECO:0000313|EMBL:EAL63860.1,
RC ECO:0000313|Proteomes:UP000002195};
RX PubMed=15875012; DOI=10.1038/nature03481;
RG The Dictyostelium discoideum Sequencing Consortium;
RA Eichinger L., Pachebat J.A., Glockner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M., Spiegler S., Tivey A., Sugano S.,
RA White B., Walker D., Woodward J., Winckler T., Tanaka Y., Shaulsky G.,
RA Schleicher M., Weinstock G., Rosenthal A., Cox E.C., Chisholm R.L.,
RA Gibbs R., Loomis W.F., Platzer M., Kay R.R., Williams J., Dear P.H.,
RA Noegel A.A., Barrell B., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAL63860.1}.
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DR EMBL; AAFI02000098; EAL63860.1; -; Genomic_DNA.
DR RefSeq; XP_637376.1; XM_632284.1.
DR AlphaFoldDB; Q54KQ4; -.
DR SMR; Q54KQ4; -.
DR STRING; 44689.Q54KQ4; -.
DR PaxDb; 44689-DDB0233435; -.
DR GeneID; 8625998; -.
DR KEGG; ddi:DDB_G0287171; -.
DR dictyBase; DDB_G0287171; -.
DR eggNOG; KOG0298; Eukaryota.
DR HOGENOM; CLU_001726_1_1_1; -.
DR InParanoid; Q54KQ4; -.
DR OMA; PTCVHRF; -.
DR PhylomeDB; Q54KQ4; -.
DR Reactome; R-DDI-8866654; E3 ubiquitin ligases ubiquitinate target proteins.
DR PRO; PR:Q54KQ4; -.
DR Proteomes; UP000002195; Chromosome 4.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0140658; F:ATP-dependent chromatin remodeler activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR GO; GO:0006974; P:DNA damage response; IBA:GO_Central.
DR GO; GO:0000209; P:protein polyubiquitination; IBA:GO_Central.
DR CDD; cd16449; RING-HC; 1.
DR CDD; cd18793; SF2_C_SNF; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.40.50.10810; Tandem AAA-ATPase domain; 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR048686; SHPRH_helical_1st.
DR InterPro; IPR038718; SNF2-like_sf.
DR InterPro; IPR049730; SNF2/RAD54-like_C.
DR InterPro; IPR000330; SNF2_N.
DR InterPro; IPR027370; Znf-RING_euk.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR45865:SF1; E3 UBIQUITIN-PROTEIN LIGASE SHPRH; 1.
DR PANTHER; PTHR45865; E3 UBIQUITIN-PROTEIN LIGASE SHPRH FAMILY MEMBER; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF21325; SHPRH_helical-1st; 1.
DR Pfam; PF00176; SNF2-rel_dom; 1.
DR Pfam; PF13445; zf-RING_UBOX; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 3.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000002195};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 762..905
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 1565..1609
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 1686..1842
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..104
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 327..423
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 589..649
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1368..1391
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1121..1148
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 42..104
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 327..356
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 369..418
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 589..635
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1872 AA; 216509 MW; 3D91FA6F4C164425 CRC64;
MNEINSEDEK EINYHQQNGS QGDETRNSSE SQNKRKKIQP KRLSQGQLNE KSWSNQQQQP
HQQNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNYI IIDNDDTPMS TTPEYENEDT
KNINDNINEL PETQKLSMGF KKRKTTYHGI LVNFEKDNSL FNKSNNNNNN GENININIGE
VMIYSDSQIK FDKPLYLYYK YGNVGTKSDG FFTNWENSKS ISTFTADSPS NVFYCLTNLK
ANHFINLVFL PVRDNNNSNK SRGTLISMQV YLIKESFEEY NNDPTSTHTN RSFKTVMNYF
LKIKDLEQME IENQLLKELE EENLLHAESE KEIEKEKEKE KEKEKEKEKE IEKEQDIEMV
DEPDNQDSSN NDHNNSLSTI DSDIFSDNNN SNSNSNSNSN SNSNSNSNSN SNSNNNNNNN
REKKKRFIFN ITELYDNVKM DSDAVEISKS KFNGQMISTL KPYQLKAVNW MLNRELNPKI
DFSPLSHNNK YNNNNNNNNN NNNNINNDII HPIWSRFLVD KREFFYNQFT GRLTLKEVLL
SDKKDDLSLM GGILADEMGL GKTVEFLGLV LSHPKPDKNV IIINPPKPII NKNNNNNNNN
NNNNNNNNNN NNNNNNNNNN NNKNNNNINN NQNNNNNEEE EEEDDNNNNN EIKKKKRKII
KKEIILNQGE FKRLNGDIIS CICGKDEESH KRGNWVKCNS CNKFQYSSCV WASNPRYRGI
SKFYFCTRCV TVPRDPSLTH QDDQEEYENR WDETTLVGSR ATLIVAPNTI FTQWQEEIVK
HTNGLKVYIY NGIYKDKINP FQLADYDLVL TTYDVLSDDS ICLTQISAGK QLRYTKIPTP
KSALKCIKWW RICLDEAQMV ESSSQTKYKK LALGLESHYR WCLTGTPIQR SLDDMFGLFE
FLRLEPFSSR YWWNCIILHK YLALGEQSFL DWFHCIVHSV MIRNSKAMIR NELQLPNQYD
NDTKLLRFSM VEAHYYQKKA NECSQEARLL FQKYFRGGRS IQDISISHLN SILAPLLVLR
QTCQHFQVGG HAVKPLTMST MTMEQLLDRL IENATIEAKN HQKSVIHSLN CLAAARIIRN
EFSIASQLYL DAINMFKSNE NHFKVDWFQE LHTFYNLNFL FKQFKNQINL IEKQIEKLSN
KENNNNNNPN NSNNQTIEEK LKDIEKIKEI ISNITDGGKI NLDDKCEKLR NSYLQGKNHQ
MLQNQKEFEE YHQKVNEALD EYDKNTNKSE KMPWFERALQ LIEEEENAKP GVVPNPFLKR
VETRLFIPRN LPQFQFSIVN KFTNFFGLSL IISKHITDLL KYRVNFIKTL TPLLHSFTEK
DVEISINCRE CCDKTQRTQN LESPVCPHCI AMDNLTLFRE KLFSKVGNQN KSRGGGGGSG
NTSMMTIDNN GLTDEQRKDI DSIRLNIGAS ESVTDSEVEI VLKLMIPLLK QIDIDIAKEG
EDFLKLLKIM KLELSSASES WASSKNYLNS FDEVDSSTTR ITLKYQGEII QPYQQQFKLN
NLVEVDQFIQ RFELEKKKSI EQFKTSNGQL LYLYNLKKSN LSTKSNTNTN NNNNNSTVTD
EKSICAICQE VFGKNVVMLL CGHSFCYDCV MFMIEKVPNC RTIQCPICRA RSNIEEISYL
STDKENGELV DNSNVKGSYG TKIESLVQSV INIQKKSIKT IQPNIIPTTT STTTTTTTTT
TNTNTNTTNS NINIKKDESI QKIIIFSQWA DVLEIISRAL KENEIQFAKA VHRGSSFEMA
INQFRKDPNV NVLLLPLIKG GNGLNLIEAT HVFLVEPILN PALEKQAINR VHRFGQNKET
NIHRFIIKNT IEEKVVQMNQ LKEQKRKNTN ENTIDLDNEQ LQKQQLLLMS GKKSKENDNI
LSKDDIEFLI LD
//
