ID Q54Q95_DICDI Unreviewed; 760 AA.
AC Q54Q95;
DT 24-MAY-2005, integrated into UniProtKB/TrEMBL.
DT 24-MAY-2005, sequence version 1.
DT 27-MAR-2024, entry version 90.
DE SubName: Full=PARP domain-containing protein {ECO:0000313|EMBL:EAL65431.1};
GN ORFNames=DDB_G0284015 {ECO:0000313|EMBL:EAL65431.1};
OS Dictyostelium discoideum (Social amoeba).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689 {ECO:0000313|EMBL:EAL65431.1, ECO:0000313|Proteomes:UP000002195};
RN [1] {ECO:0000313|EMBL:EAL65431.1, ECO:0000313|Proteomes:UP000002195}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4 {ECO:0000313|EMBL:EAL65431.1,
RC ECO:0000313|Proteomes:UP000002195};
RX PubMed=15875012; DOI=10.1038/nature03481;
RG The Dictyostelium discoideum Sequencing Consortium;
RA Eichinger L., Pachebat J.A., Glockner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M., Spiegler S., Tivey A., Sugano S.,
RA White B., Walker D., Woodward J., Winckler T., Tanaka Y., Shaulsky G.,
RA Schleicher M., Weinstock G., Rosenthal A., Cox E.C., Chisholm R.L.,
RA Gibbs R., Loomis W.F., Platzer M., Kay R.R., Williams J., Dear P.H.,
RA Noegel A.A., Barrell B., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAL65431.1}.
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DR EMBL; AAFI02000059; EAL65431.1; -; Genomic_DNA.
DR RefSeq; XP_638785.1; XM_633693.1.
DR AlphaFoldDB; Q54Q95; -.
DR SMR; Q54Q95; -.
DR PaxDb; 44689-DDB0232949; -.
DR GeneID; 8624374; -.
DR KEGG; ddi:DDB_G0284015; -.
DR dictyBase; DDB_G0284015; -.
DR eggNOG; ENOG502S0P0; Eukaryota.
DR HOGENOM; CLU_367026_0_0_1; -.
DR InParanoid; Q54Q95; -.
DR OMA; WYGKGIY; -.
DR Proteomes; UP000002195; Chromosome 4.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0003906; F:DNA-(apurinic or apyrimidinic site) endonuclease activity; IEA:InterPro.
DR GO; GO:0003950; F:NAD+ ADP-ribosyltransferase activity; IEA:InterPro.
DR GO; GO:0006302; P:double-strand break repair; IEA:InterPro.
DR Gene3D; 3.30.720.50; -; 1.
DR Gene3D; 3.90.228.10; -; 1.
DR Gene3D; 3.40.50.10190; BRCT domain; 1.
DR InterPro; IPR039253; APLF.
DR InterPro; IPR019406; APLF_PBZ.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR012317; Poly(ADP-ribose)pol_cat_dom.
DR InterPro; IPR004170; WWE-dom.
DR InterPro; IPR037197; WWE_dom_sf.
DR PANTHER; PTHR21315:SF3; BRCT DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR21315; UNCHARACTERIZED; 1.
DR Pfam; PF00533; BRCT; 1.
DR Pfam; PF00644; PARP; 1.
DR Pfam; PF02825; WWE; 1.
DR Pfam; PF10283; zf-CCHH; 1.
DR SMART; SM00292; BRCT; 1.
DR SUPFAM; SSF56399; ADP-ribosylation; 1.
DR SUPFAM; SSF52113; BRCT domain; 1.
DR SUPFAM; SSF117839; WWE domain; 1.
DR PROSITE; PS50172; BRCT; 1.
DR PROSITE; PS50918; WWE; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002195}.
FT DOMAIN 138..212
FT /note="WWE"
FT /evidence="ECO:0000259|PROSITE:PS50918"
FT DOMAIN 599..693
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT REGION 1..72
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 325..370
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 712..737
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 13..72
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 333..357
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 760 AA; 85733 MW; EF3A06366F249669 CRC64;
MPPKRKLAGL DDEDSSQANN ATVAIVTSTT STTTKTSSSS VLTSNSSSNT SNNNKTNNDN
NNNNNDDRCP IPMTSDSKQI YWQYQNSEFE WKDIKYNLLD SIEKVYQKTP KDSDEQIFDD
IVIIFSEMKM YNSKDNAKTK KSIKRVFRQP IWSWEKARGE FKAFKPDISL KVESSFLKGL
SKASINAERY INFSSFEQAR FDDDTKTRRV RRNHIDVSDY HNPYWYFLHS HTQTTTPKIT
TKSWKEFDGS HDDINKAFKN LIEKGENTQI KISDDETICF LSMTLIKKGS DTVVVKIDNG
PVLPLKKSYS QLSEQERKDM INKMLSGQTS DSGNNKKKKD NDSDDDDDDK SKKKQKTDSG
NSGNYLPGEL DVLKKDKPMK YILRPTRHLS GVSQADAHFR IAESQFYRLL TSGNSMKVTK
VEYICNPTLT KKFNAKMEEY KSKKYEHSDP VFGFHGTAAK NIIPICTNNF SVPGGGSGVK
HATDSGWYGK GIYFSEFTDY SIGYIKDCTK ILLCKVLLGK AYKCSTLIHG KPCVTGYTSH
LSPDEKELVI FHPDQILPVY IVHYQSGATA GTAVSGLNVA PTGVYGNFLS EYNQANLMPA
SNILNGKTIS LLGTLSTVQY NIQNLITKHG GSFHSHTTNV NGCTQLVTTS SDYFNLGTKV
QNANLNGVPI VNENWIYKTI ISNKLKKVTS FSFNAPIKSK SKTEILKPIP LEQLEYDDDD
EDDEDEDDSK KKKAPCKYGD KCYRKSADHF KEFSHSFLID
//
