ID Q54QB8_DICDI Unreviewed; 1041 AA.
AC Q54QB8;
DT 24-MAY-2005, integrated into UniProtKB/TrEMBL.
DT 24-MAY-2005, sequence version 1.
DT 27-MAR-2024, entry version 112.
DE RecName: Full=DNA mismatch repair proteins mutS family domain-containing protein {ECO:0000259|PROSITE:PS00486};
GN Name=msh4 {ECO:0000313|EMBL:EAL65466.1};
GN ORFNames=DDB_G0283957 {ECO:0000313|EMBL:EAL65466.1};
OS Dictyostelium discoideum (Social amoeba).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689 {ECO:0000313|EMBL:EAL65466.1, ECO:0000313|Proteomes:UP000002195};
RN [1] {ECO:0000313|EMBL:EAL65466.1, ECO:0000313|Proteomes:UP000002195}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4 {ECO:0000313|EMBL:EAL65466.1,
RC ECO:0000313|Proteomes:UP000002195};
RX PubMed=15875012; DOI=10.1038/nature03481;
RG The Dictyostelium discoideum Sequencing Consortium;
RA Eichinger L., Pachebat J.A., Glockner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M., Spiegler S., Tivey A., Sugano S.,
RA White B., Walker D., Woodward J., Winckler T., Tanaka Y., Shaulsky G.,
RA Schleicher M., Weinstock G., Rosenthal A., Cox E.C., Chisholm R.L.,
RA Gibbs R., Loomis W.F., Platzer M., Kay R.R., Williams J., Dear P.H.,
RA Noegel A.A., Barrell B., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAL65466.1}.
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DR EMBL; AAFI02000058; EAL65466.1; -; Genomic_DNA.
DR RefSeq; XP_638826.1; XM_633734.1.
DR AlphaFoldDB; Q54QB8; -.
DR SMR; Q54QB8; -.
DR STRING; 44689.Q54QB8; -.
DR PaxDb; 44689-DDB0229912; -.
DR GeneID; 8624350; -.
DR KEGG; ddi:DDB_G0283957; -.
DR dictyBase; DDB_G0283957; msh4.
DR eggNOG; KOG0220; Eukaryota.
DR HOGENOM; CLU_002472_7_3_1; -.
DR InParanoid; Q54QB8; -.
DR OMA; KMTMLYK; -.
DR PhylomeDB; Q54QB8; -.
DR Proteomes; UP000002195; Chromosome 4.
DR GO; GO:0032301; C:MutSalpha complex; IBA:GO_Central.
DR GO; GO:0000228; C:nuclear chromosome; ISS:dictyBase.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IBA:GO_Central.
DR GO; GO:0006298; P:mismatch repair; IBA:GO_Central.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR PANTHER; PTHR11361:SF21; MUTS PROTEIN HOMOLOG 4; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 2.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Meiosis {ECO:0000256|ARBA:ARBA00023254};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000002195}.
FT DOMAIN 870..886
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT REGION 20..84
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 174..240
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 982..1001
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 30..54
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 55..75
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 176..240
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1041 AA; 118921 MW; F577B603C4DF81D8 CRC64;
MNNGISKNIS FYKKINYTHN KPPAPHIPQQ PQFLNNTQKN NDTIINNNNN ADNDDIECIY
DDYEFDDDDN NNDNDNDNDK ADKNSYNNYI YKEITLNDFG DENDNESDLD DLDFDFEPTI
IKNIENNKTS AINSKSFEQT SKSNHKLINY NPICKDIDEN DLLLISKPKI NIPMKTPPSL
SKNNNTNSKP MSSLLNSKKS TSTINTPKIN KTFPNTIQNS LRKSGSVNNE NNSINSNIIK
NKTKNHSGSI VAICENRTRE IGYSSYNIES GEIETGQFCD SQTYFHLYTK LYILNPSIIV
IPPIEQNREM VKLIENAYPN VKIIPIIKKL FNENDGISLM NQYCLIDKIS IIEKFTKDKV
LSLSSFNALI KYLEQDGIMF VKNCIRIKYS GSENSMQIDA ETIKNLELIH SSKDGSRNCT
LYQSINNTST SQGSRLLISA IVQPSNDFET IKHRQNAIKQ LLSNQRVVFT LTPLLSKIQD
IDKTLLLFSQ QNKQVTIKSI ETSIKCFIDF KNIFELLPKI SNLLNSGTIC DNPMLNLIKG
KLNNETNNIL IKESSKVLNV NLNFQLSKQD QQHQQKEQQQ QQQQQVNKIN YKIIMYIKDG
VNGLLDVCKK TYKEITDDIN KLTKYYKEQF KLPQLKLQHC QTKGYYYSLP CKNKALFHLP
NVFVRSSYRN QKYYLFSEEL TSLSRRSREV FEEIIILSAQ SIEKLIEFYR SHISELYNIS
ESISLLDFLV SGALYSLQLD QSVCPEIFNG KGPLAIKSGY HPLQLKKSKK KESFSTCFVP
NDTLINETAS FQLIHGCNMS GKSTYIQQVA LLTIVAHIGY FLPAEFATVP IVDQIISRLG
TSDNIQSNAS TFMTEMKEIS YILENTTESS LVIIDELGRG TSNMDGSSIA WSISEHLSMI
GCYTLFVTHY QQLLNLATFY PNIRVYHFQV SKDDSSGLKY NYLFSEGVSS IDSYGVETAE
LAGIDSKVIQ SAKTIRNLLE SKSNNNQINP NTNNQSINQY HHPSRDSYQL LQKLLNLKFS
KLSDVQLKNY LLKLKEDFNF S
//
