GenomeNet

Database: UniProt
Entry: Q54QC1
LinkDB: Q54QC1
Original site: Q54QC1 
ID   GPDM_DICDI              Reviewed;         638 AA.
AC   Q54QC1;
DT   16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   05-DEC-2018, entry version 77.
DE   RecName: Full=Probable glycerol-3-phosphate dehydrogenase, mitochondrial;
DE            Short=GPD-M;
DE            Short=GPDH-M;
DE            EC=1.1.5.3;
DE   Flags: Precursor;
GN   ORFNames=DDB_G0283951;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Mycetozoa; Dictyostelids; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A.,
RA   Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q.,
RA   Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F.,
RA   Bankier A.T., Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P.,
RA   Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P.,
RA   Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N.,
RA   Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M.,
RA   Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I.,
RA   Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R.,
RA   Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C.,
RA   Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D.,
RA   Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S.,
RA   Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T.,
RA   Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A.,
RA   Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M.,
RA   Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G.,
RA   Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a quinone + sn-glycerol 3-phosphate = a quinol +
CC         dihydroxyacetone phosphate; Xref=Rhea:RHEA:18977,
CC         ChEBI:CHEBI:24646, ChEBI:CHEBI:57597, ChEBI:CHEBI:57642,
CC         ChEBI:CHEBI:132124; EC=1.1.5.3;
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
CC   -!- PATHWAY: Polyol metabolism; glycerol degradation via glycerol
CC       kinase pathway; glycerone phosphate from sn-glycerol 3-phosphate
CC       (anaerobic route): step 1/1.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the FAD-dependent glycerol-3-phosphate
CC       dehydrogenase family. {ECO:0000305}.
DR   EMBL; AAFI02000058; EAL65463.1; -; Genomic_DNA.
DR   RefSeq; XP_638823.1; XM_633731.1.
DR   ProteinModelPortal; Q54QC1; -.
DR   SMR; Q54QC1; -.
DR   STRING; 44689.DDB0185769; -.
DR   PaxDb; Q54QC1; -.
DR   PRIDE; Q54QC1; -.
DR   EnsemblProtists; EAL65463; EAL65463; DDB_G0283951.
DR   GeneID; 8624347; -.
DR   KEGG; ddi:DDB_G0283951; -.
DR   dictyBase; DDB_G0283951; -.
DR   eggNOG; KOG0042; Eukaryota.
DR   eggNOG; COG0578; LUCA.
DR   InParanoid; Q54QC1; -.
DR   KO; K00111; -.
DR   OMA; MDNPTVK; -.
DR   PhylomeDB; Q54QC1; -.
DR   Reactome; R-DDI-1483166; Synthesis of PA.
DR   Reactome; R-DDI-163560; Triglyceride catabolism.
DR   UniPathway; UPA00618; UER00673.
DR   PRO; PR:Q54QC1; -.
DR   Proteomes; UP000002195; Chromosome 4.
DR   Proteomes; UP000002195; Unassembled WGS sequence.
DR   GO; GO:0009331; C:glycerol-3-phosphate dehydrogenase complex; IEA:InterPro.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0004368; F:glycerol-3-phosphate dehydrogenase (quinone) activity; IBA:GO_Central.
DR   GO; GO:0004367; F:glycerol-3-phosphate dehydrogenase [NAD+] activity; IBA:GO_Central.
DR   GO; GO:0052591; F:sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity; IEA:UniProtKB-EC.
DR   GO; GO:0019563; P:glycerol catabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0046168; P:glycerol-3-phosphate catabolic process; IBA:GO_Central.
DR   Gene3D; 1.10.8.870; -; 1.
DR   Gene3D; 3.50.50.60; -; 1.
DR   InterPro; IPR031656; DAO_C.
DR   InterPro; IPR038299; DAO_C_sf.
DR   InterPro; IPR006076; FAD-dep_OxRdtase.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR000447; G3P_DH_FAD-dep.
DR   PANTHER; PTHR11985; PTHR11985; 1.
DR   Pfam; PF01266; DAO; 1.
DR   Pfam; PF16901; DAO_C; 1.
DR   PRINTS; PR01001; FADG3PDH.
DR   SUPFAM; SSF51905; SSF51905; 1.
DR   PROSITE; PS00977; FAD_G3PDH_1; 1.
DR   PROSITE; PS00978; FAD_G3PDH_2; 1.
PE   3: Inferred from homology;
KW   Complete proteome; FAD; Flavoprotein; Mitochondrion; Oxidoreductase;
KW   Reference proteome; Transit peptide.
FT   TRANSIT       1      ?       Mitochondrion. {ECO:0000255}.
FT   CHAIN         ?    638       Probable glycerol-3-phosphate
FT                                dehydrogenase, mitochondrial.
FT                                /FTId=PRO_0000355967.
FT   NP_BIND     100    128       FAD. {ECO:0000255}.
SQ   SEQUENCE   638 AA;  71425 MW;  19DA700617840BBC CRC64;
     MNQLLSKSFK PLVVAGVAVI GISAFSGNRA YDEYRKERES ISKKMINDLN ENKITMFDYF
     QECKTLGRDE QLSKLNKLSK VYNKQKLNEQ ENQEELIDLD LIVIGGGATG TGVALDAQSR
     GMKVALFEKY DFSSGTSSKS TKLVHGGIRY LESAIMKLKP SELTLVKEAL RERSNLLNNA
     PHLSRQLPIV IPAYSIFDAS KFWIGCKLYD FFYPFNDIPK SYLQTSAQTY KEFPFLREGL
     VSSVVYYDGQ HNDSRMNVSL ALTAAQQGAL TLNYTEVVEL IKDDKINNNN KQQQLKGVVI
     RDRLTGKKYS VPAKCVVNAT GPYCDSIRNL DDPRADPIIT ASSGVHIMLP GNLIPSDKGF
     LNPKTKDGRV LFILPFEGKT LVGTTDDPSP IIENPQPLEK DVEFILDSIK EYSNPNVKLD
     KSQVLACWSG IRPLVSDEPA AQGDNKKSTS QVTRSHSLRM SESGLITIVG GKWTTYRSMA
     EATVNLVCSK HDIFTPKGCI TKNLPLIGGE KYYNTLNQYL IKNFNLPEDI AEHLAHSYGD
     QAPFVAKLAN ENGSNKRLVE GYPYIEAEVT YGVKKEYACT AEDIIGRRTR LSFLDHDKAE
     IALPKIINIM APLLKWSNER KKEELKNSQN YLKTMTSK
//
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