ID C5174_DICDI Reviewed; 483 AA.
AC Q54QD0;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 27-MAR-2024, entry version 102.
DE RecName: Full=Probable cytochrome P450 517A4;
DE EC=1.14.-.-;
GN Name=cyp517A4; ORFNames=DDB_G0283933;
OS Dictyostelium discoideum (Social amoeba).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- COFACTOR:
CC Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the cytochrome P450 family. {ECO:0000305}.
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DR EMBL; AAFI02000058; EAL65454.1; -; Genomic_DNA.
DR RefSeq; XP_638814.1; XM_633722.1.
DR AlphaFoldDB; Q54QD0; -.
DR SMR; Q54QD0; -.
DR STRING; 44689.Q54QD0; -.
DR PaxDb; 44689-DDB0233016; -.
DR EnsemblProtists; EAL65454; EAL65454; DDB_G0283933.
DR GeneID; 8624338; -.
DR KEGG; ddi:DDB_G0283933; -.
DR dictyBase; DDB_G0283933; cyp517A4.
DR eggNOG; KOG0156; Eukaryota.
DR HOGENOM; CLU_001570_22_0_1; -.
DR InParanoid; Q54QD0; -.
DR OMA; RECRKQT; -.
DR PhylomeDB; Q54QD0; -.
DR PRO; PR:Q54QD0; -.
DR Proteomes; UP000002195; Chromosome 4.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR CDD; cd20617; CYP1_2-like; 1.
DR Gene3D; 1.10.630.10; Cytochrome P450; 1.
DR InterPro; IPR001128; Cyt_P450.
DR InterPro; IPR017972; Cyt_P450_CS.
DR InterPro; IPR002401; Cyt_P450_E_grp-I.
DR InterPro; IPR036396; Cyt_P450_sf.
DR PANTHER; PTHR24300; CYTOCHROME P450 508A4-RELATED; 1.
DR PANTHER; PTHR24300:SF118; CYTOCHROME P450 508C1-RELATED; 1.
DR Pfam; PF00067; p450; 1.
DR PRINTS; PR00463; EP450I.
DR SUPFAM; SSF48264; Cytochrome P450; 1.
DR PROSITE; PS00086; CYTOCHROME_P450; 1.
PE 3: Inferred from homology;
KW Heme; Iron; Membrane; Metal-binding; Monooxygenase; Oxidoreductase;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..483
FT /note="Probable cytochrome P450 517A4"
FT /id="PRO_0000318829"
FT TRANSMEM 1..21
FT /note="Helical"
FT /evidence="ECO:0000255"
FT BINDING 429
FT /ligand="heme"
FT /ligand_id="ChEBI:CHEBI:30413"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="axial binding residue"
FT /evidence="ECO:0000250"
SQ SEQUENCE 483 AA; 55752 MW; 45416CB09F18D120 CRC64;
MEIVNVLLFL IILFLVKDFV KKNKKIHTKS PSGPIAFPIL GNVVQIRFWE LFKIQEHELI
GNYSKKYNGV VRAWIGERLF LFVSNYDVVK YFQKDENFLY RPSLLVPGWR YASSNGLGVM
SSSDDEWKRA KSSVSQSLRV HTSKKLMEEK AIEFIDSLEK ISNNNEIFYP KGHIQGYACS
MLFKYMFNQD LSVESGMSRT IGNAVEHVFG NLSKLTAFDC FEIFSPLYDW FFTRRLKGCD
IVRQIISSQN ENHLKSIDPS KPRDLMDDLL IEYGLNEITK EDTMQINQIC FDIFGPAVGT
VTITMNWVIL QLCNRPELQE IAYQEIKKAV KDDEYVNLNH KQNAPYIVAF IKETMRLCSN
GFGLPRTAKN DQICGDFFIP KDAIIFINYL EISQNEEIFK NAKEFNPTRY LDESLPVPNI
HFGVGQRACP GRFVAIDKMF LGISNLLLKY KLKSQNGEKI DDTIHFSVSL KAKDYGIKLE
KRI
//
