ID C513E_DICDI Reviewed; 504 AA.
AC Q54SN0;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 27-MAR-2024, entry version 103.
DE RecName: Full=Probable cytochrome P450 513E1;
DE EC=1.14.-.-;
GN Name=cyp513E1; ORFNames=DDB_G0282353;
OS Dictyostelium discoideum (Social amoeba).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- COFACTOR:
CC Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the cytochrome P450 family. {ECO:0000305}.
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DR EMBL; AAFI02000047; EAL66298.1; -; Genomic_DNA.
DR RefSeq; XP_640271.1; XM_635179.1.
DR AlphaFoldDB; Q54SN0; -.
DR SMR; Q54SN0; -.
DR STRING; 44689.Q54SN0; -.
DR PaxDb; 44689-DDB0232342; -.
DR EnsemblProtists; EAL66298; EAL66298; DDB_G0282353.
DR GeneID; 8623532; -.
DR KEGG; ddi:DDB_G0282353; -.
DR dictyBase; DDB_G0282353; cyp513E1.
DR eggNOG; KOG0156; Eukaryota.
DR HOGENOM; CLU_001570_22_0_1; -.
DR InParanoid; Q54SN0; -.
DR OMA; SFTTTEW; -.
DR PhylomeDB; Q54SN0; -.
DR PRO; PR:Q54SN0; -.
DR Proteomes; UP000002195; Chromosome 3.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR CDD; cd20617; CYP1_2-like; 1.
DR Gene3D; 1.10.630.10; Cytochrome P450; 1.
DR InterPro; IPR001128; Cyt_P450.
DR InterPro; IPR017972; Cyt_P450_CS.
DR InterPro; IPR002401; Cyt_P450_E_grp-I.
DR InterPro; IPR036396; Cyt_P450_sf.
DR PANTHER; PTHR24303:SF11; CYTOCHROME P450 513A1-RELATED; 1.
DR PANTHER; PTHR24303; HEME-BINDING MONOOXYGENASE FAMILY; 1.
DR Pfam; PF00067; p450; 1.
DR PRINTS; PR00463; EP450I.
DR PRINTS; PR00385; P450.
DR SUPFAM; SSF48264; Cytochrome P450; 1.
DR PROSITE; PS00086; CYTOCHROME_P450; 1.
PE 3: Inferred from homology;
KW Heme; Iron; Membrane; Metal-binding; Monooxygenase; Oxidoreductase;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..504
FT /note="Probable cytochrome P450 513E1"
FT /id="PRO_0000318818"
FT TRANSMEM 1..21
FT /note="Helical"
FT /evidence="ECO:0000255"
FT BINDING 450
FT /ligand="heme"
FT /ligand_id="ChEBI:CHEBI:30413"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="axial binding residue"
FT /evidence="ECO:0000250"
SQ SEQUENCE 504 AA; 57923 MW; 297317C892FB2C12 CRC64;
MNLYISILIL IISLIIFFKN NNRISKINSK IPGPIRLPIF GNLLQINKDP HIQFQKWYEK
YGVIYSIRLG NIETVVFTGY PIFKKAFIEN SQIFAPRFQH LSRFEANGCK NLIGSNDEIH
STLKKLILTE ITSNKIKKME NHIVLECENL CKQLDKHCQD GLPFSLNMYF KLFSLNIILR
FLFGTINNSY QDKSNQDIVD VIIEFLHYGG NPIMSDFIPI LKPFYKQNKF FKFYPILCDH
LNKLIENYKN NKQLQKQQKQ QQNEDDDDDD DGTIIGKLLK EYHNGKISWT SVVSTCVDVF
LAGVDSTSNS TIFTLIALVN NSNCQEKLFN EIKNNLKKSD DGHDEIVIRH SLYRSSIPYL
SLVMKEVYRL YSVILIGLPH ITSEDVEIEG YKIAKGTQII QNVFSTHLCE KTFPMSKSFI
PERFIETGSN NMFGGGQTNL VHFGTGVRDC VGKSLADCEI FTVLATLINR YQFINPTLEP
LNDIGSFGIA YQPPINNFII KKRL
//
