ID Q54VC3_DICDI Unreviewed; 425 AA.
AC Q54VC3;
DT 24-MAY-2005, integrated into UniProtKB/TrEMBL.
DT 24-MAY-2005, sequence version 1.
DT 08-NOV-2023, entry version 70.
DE RecName: Full=RING-type domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=DDB_G0280457 {ECO:0000313|EMBL:EAL67207.1};
OS Dictyostelium discoideum (Social amoeba).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689 {ECO:0000313|EMBL:EAL67207.1, ECO:0000313|Proteomes:UP000002195};
RN [1] {ECO:0000313|EMBL:EAL67207.1, ECO:0000313|Proteomes:UP000002195}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4 {ECO:0000313|EMBL:EAL67207.1,
RC ECO:0000313|Proteomes:UP000002195};
RX PubMed=15875012; DOI=10.1038/nature03481;
RG The Dictyostelium discoideum Sequencing Consortium;
RA Eichinger L., Pachebat J.A., Glockner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M., Spiegler S., Tivey A., Sugano S.,
RA White B., Walker D., Woodward J., Winckler T., Tanaka Y., Shaulsky G.,
RA Schleicher M., Weinstock G., Rosenthal A., Cox E.C., Chisholm R.L.,
RA Gibbs R., Loomis W.F., Platzer M., Kay R.R., Williams J., Dear P.H.,
RA Noegel A.A., Barrell B., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the TMEM129 family.
CC {ECO:0000256|ARBA:ARBA00007332}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAL67207.1}.
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DR EMBL; AAFI02000036; EAL67207.1; -; Genomic_DNA.
DR RefSeq; XP_641186.1; XM_636094.1.
DR AlphaFoldDB; Q54VC3; -.
DR SMR; Q54VC3; -.
DR PaxDb; 44689-DDB0205211; -.
DR GeneID; 8622567; -.
DR KEGG; ddi:DDB_G0280457; -.
DR dictyBase; DDB_G0280457; -.
DR eggNOG; ENOG502RCAC; Eukaryota.
DR HOGENOM; CLU_646291_0_0_1; -.
DR InParanoid; Q54VC3; -.
DR OMA; PTMCKEC; -.
DR Proteomes; UP000002195; Chromosome 3.
DR GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR GO; GO:0016567; P:protein ubiquitination; IEA:InterPro.
DR InterPro; IPR018801; TM129.
DR PANTHER; PTHR31322; E3 UBIQUITIN-PROTEIN LIGASE TM129; 1.
DR PANTHER; PTHR31322:SF2; E3 UBIQUITIN-PROTEIN LIGASE TM129; 1.
DR Pfam; PF10272; Tmpp129; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000002195};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT REGION 181..214
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 278..425
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 64..109
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 191..205
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 288..314
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 315..347
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 356..375
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 385..418
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 425 AA; 47774 MW; 91B7507DE2561268 CRC64;
MDVHFNLFVS NLQNNALSIP NSQLLLRLIS NLTSDDSNFP PIVQKVKSFK DRNEAFSRDL
AKFIRKSKES LAELSKELDK FVDDDPVLVA QLKEELNTNQ KEMHNALTKI EPTVTSQINT
IKKLSDHIFP PTEELFRKKV LERLEKNKNQ QVPISKKLRC TICLDNDSDV IIKRTCKPPS
NGIPTCEPPP SLIGRNNSSS QSSTSGPTSP PPPPRNTFCE KASCNCGPVT CMECVIKHYW
SSSSNGLKSY STCPCCRAEF CTKDIYKVEY INDLEEKPKE EESIKVDNEL NSNTTTTTTT
TSSASASSSS STNKSSSKKR KDDSNNSNDN KRFKEQKDTD KNSFQKLSKS SKKNKTSVKI
SQDKSLERKA DSDDDGDSEN KDENNDPSSN SNNNNNNNNN NNNNNNNNNN NKNSNPFKRL
ISFWK
//
