ID Q54VZ0_DICDI Unreviewed; 1032 AA.
AC Q54VZ0;
DT 24-MAY-2005, integrated into UniProtKB/TrEMBL.
DT 24-MAY-2005, sequence version 1.
DT 08-NOV-2023, entry version 96.
DE RecName: Full=EGF-like domain-containing protein {ECO:0000259|PROSITE:PS50026};
GN ORFNames=DDB_G0280029 {ECO:0000313|EMBL:EAL67486.1};
OS Dictyostelium discoideum (Social amoeba).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689 {ECO:0000313|EMBL:EAL67486.1, ECO:0000313|Proteomes:UP000002195};
RN [1] {ECO:0000313|EMBL:EAL67486.1, ECO:0000313|Proteomes:UP000002195}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4 {ECO:0000313|EMBL:EAL67486.1,
RC ECO:0000313|Proteomes:UP000002195};
RX PubMed=15875012; DOI=10.1038/nature03481;
RG The Dictyostelium discoideum Sequencing Consortium;
RA Eichinger L., Pachebat J.A., Glockner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M., Spiegler S., Tivey A., Sugano S.,
RA White B., Walker D., Woodward J., Winckler T., Tanaka Y., Shaulsky G.,
RA Schleicher M., Weinstock G., Rosenthal A., Cox E.C., Chisholm R.L.,
RA Gibbs R., Loomis W.F., Platzer M., Kay R.R., Williams J., Dear P.H.,
RA Noegel A.A., Barrell B., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAL67486.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAFI02000035; EAL67486.1; -; Genomic_DNA.
DR RefSeq; XP_641460.1; XM_636368.1.
DR AlphaFoldDB; Q54VZ0; -.
DR SMR; Q54VZ0; -.
DR PaxDb; 44689-DDB0218216; -.
DR GeneID; 8622346; -.
DR KEGG; ddi:DDB_G0280029; -.
DR eggNOG; KOG1225; Eukaryota.
DR HOGENOM; CLU_003793_0_0_1; -.
DR InParanoid; Q54VZ0; -.
DR OMA; NTIKECP; -.
DR PhylomeDB; Q54VZ0; -.
DR Proteomes; UP000002195; Chromosome 3.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00055; EGF_Lam; 2.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR002049; LE_dom.
DR PANTHER; PTHR24032:SF13; EGF-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24032; EGF-LIKE DOMAIN-CONTAINING PROTEIN-RELATED-RELATED; 1.
DR Pfam; PF00053; Laminin_EGF; 1.
DR PRINTS; PR00011; EGFLAMININ.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS00022; EGF_1; 3.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 2.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002195};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 991..1015
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 532..568
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 570..606
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 558..567
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 596..605
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1032 AA; 114216 MW; FFB7F027778296EE CRC64;
MNKKKKKKKR KFTILNIVLK SNNNAYQISS LDFQCFSKIS QVTISNSNIS SSFLRGNTTI
EFISFSNNTI EYNELFSSQI NTKLKNVFIT NIPPPNSQIN INFSIIASLS NLQFQLNTWG
ENRTSDFTQF SLIPNDNFIY TIFFNGALIS PSIVDLRNLT ILNYIDLRNV ILDFNYQGKI
PLILPQSVTS LGISGSSFSS VNEFIGNYPR ISTIAISFNQ IPDNFTEWRN RGYASFDVNN
NKLQGTIDSS WCTTVLKIGD NQLSGKLPSC YTCHLLSDYV KFMIIGGKNS FTNVDPIPEC
TTLIPNLRYN SSTKELTLYG DDLGFYTENV IVPGFDYSFS PKIQSKLFVA SNVIQYDLPQ
ILNFKFPGAN KTFTLSTIQK PPIINTVIAT VQSYSVILEG SFFNYNISSI EIFIGDVQCS
IVSATFYKVE CLTFETYEKN IIGKVSINIK DYYYSNLTIL ETSVIAYLNQ TTQIKNCQLD
CISLGGFCNT LIGQCNIDCP NNCTGSLSGT CERSTGVCIC NIGYQGIDCS VPIHSCPSNC
NAQSNQGTCN YQNGICQCSP NYQGLDCSLP FKVCTSDCSS PLNQGSCNNQ TGICQCIPNY
QGSNCNIPSH YITSVIPCSI DGGEVLINGW FGNNNDGTNL LSSYNIVIGS LDCIVTSINE
TEIKCNLGAG TGTKNIKIIN SINPNVIFNG NGLFNYQNPI KTCPNSCTSL NNGKCNSNTG
ECQCSDKFSG FDCSTPITII ESAPPTNTSI NKDTGGIELT NQDTIYEISI ISLNEISIDG
SIIKSHQLKG NWSSDNTTIT PDSNYFKFSQ KLINNTCKIT FTIEEIKLRD KSFTFGTTTF
KVEKDSIKLS VLIQDYQYQS SLNTLQLIFY SAVGDDTNSN SNNDCNKQDT SIDTSNANNQ
QISNYIQISK NSKTLVGRFI NQVIADSRST FMSSTIIKDN NKSSSSSSSS SVMLGLNLPH
CKECLIDPDF SVLVSPDFKE SCNESTNKNK WLIPVVVVVP VVGCAVIATI SILMYRKNRY
RIQLLKLRTF KK
//
