ID Y9745_DICDI Reviewed; 410 AA.
AC Q54WD3;
DT 20-APR-2010, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 24-JAN-2024, entry version 71.
DE RecName: Full=TNF receptor-associated factor family protein DDB_G0279745;
GN ORFNames=DDB_G0279745;
OS Dictyostelium discoideum (Social amoeba).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Probable adapter protein and signal transducer that links
CC members of the tumor necrosis factor receptor family to different
CC signaling pathways by association with the receptor cytoplasmic domain
CC and kinases. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- DOMAIN: The MATH/TRAF domain binds to receptor cytoplasmic domains.
CC -!- SIMILARITY: Belongs to the TNF receptor-associated factor family.
CC {ECO:0000305}.
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DR EMBL; AAFI02000032; EAL67552.1; -; Genomic_DNA.
DR RefSeq; XP_641525.1; XM_636433.1.
DR AlphaFoldDB; Q54WD3; -.
DR STRING; 44689.Q54WD3; -.
DR PaxDb; 44689-DDB0206007; -.
DR EnsemblProtists; EAL67552; EAL67552; DDB_G0279745.
DR GeneID; 8622198; -.
DR KEGG; ddi:DDB_G0279745; -.
DR dictyBase; DDB_G0279745; -.
DR HOGENOM; CLU_671620_0_0_1; -.
DR InParanoid; Q54WD3; -.
DR PhylomeDB; Q54WD3; -.
DR PRO; PR:Q54WD3; -.
DR Proteomes; UP000002195; Chromosome 3.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR024957; Cep57_MT-bd_dom.
DR InterPro; IPR008974; TRAF-like.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR10131:SF65; RING FINGER PROTEIN DG17-RELATED; 1.
DR PANTHER; PTHR10131; TNF RECEPTOR ASSOCIATED FACTOR; 1.
DR Pfam; PF06657; Cep57_MT_bd; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF49599; TRAF domain-like; 1.
PE 3: Inferred from homology;
KW Coiled coil; Cytoplasm; Metal-binding; Reference proteome; Repeat; Zinc;
KW Zinc-finger.
FT CHAIN 1..410
FT /note="TNF receptor-associated factor family protein
FT DDB_G0279745"
FT /id="PRO_0000393771"
FT ZN_FING 27..67
FT /note="RING-type; degenerate"
FT ZN_FING 81..154
FT /note="TRAF-type 1"
FT ZN_FING 154..213
FT /note="TRAF-type 2"
FT COILED 216..284
FT /evidence="ECO:0000255"
SQ SEQUENCE 410 AA; 47122 MW; C7188CE9E1012192 CRC64;
MVRNSEITLE QIFKEGRINL ENDDYNCVIC SFPLFDGLQC KRGHGACKSC WEKIIGENGK
KECHSCRISI KSLDDLSKNL YLEKEIFKQK VACLNNGREK FGNTLVIKSD GGCKRQDIPI
EKLLHHIKNE CGYLLIDCKY SRDCKYYKQI SLEQHQNECQ FMSIHCPALC GKKDSRMNIN
KHLETPNSCK PLISINNSNN SNGNGNGIDD ESIIKLSNSI VEIQKSYQNQ IKKIKENSES
EIAALKDSLY YSKSRIKNLE DEVEELKDRF STLESMINKL DDSATSRSGT ILINGWKMKL
KSLDVGHSIV EEQFYIGTNR FYIRIYPFGD SYDNQGYVTV KLGRIDGEEY HLDIGLKVSI
KGFDNKKKVL LSYYPGDIAH NIDQLVETWE TSKEFKMILH FKVDLKPKIK
//
