ID Q54XJ7_DICDI Unreviewed; 1313 AA.
AC Q54XJ7;
DT 24-MAY-2005, integrated into UniProtKB/TrEMBL.
DT 24-MAY-2005, sequence version 1.
DT 27-MAR-2024, entry version 94.
DE RecName: Full=SH2 domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=DDB_G0278895 {ECO:0000313|EMBL:EAL68049.1};
OS Dictyostelium discoideum (Social amoeba).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689 {ECO:0000313|EMBL:EAL68049.1, ECO:0000313|Proteomes:UP000002195};
RN [1] {ECO:0000313|EMBL:EAL68049.1, ECO:0000313|Proteomes:UP000002195}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4 {ECO:0000313|EMBL:EAL68049.1,
RC ECO:0000313|Proteomes:UP000002195};
RX PubMed=15875012; DOI=10.1038/nature03481;
RG The Dictyostelium discoideum Sequencing Consortium;
RA Eichinger L., Pachebat J.A., Glockner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M., Spiegler S., Tivey A., Sugano S.,
RA White B., Walker D., Woodward J., Winckler T., Tanaka Y., Shaulsky G.,
RA Schleicher M., Weinstock G., Rosenthal A., Cox E.C., Chisholm R.L.,
RA Gibbs R., Loomis W.F., Platzer M., Kay R.R., Williams J., Dear P.H.,
RA Noegel A.A., Barrell B., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAL68049.1}.
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DR EMBL; AAFI02000024; EAL68049.1; -; Genomic_DNA.
DR RefSeq; XP_647806.1; XM_642714.1.
DR AlphaFoldDB; Q54XJ7; -.
DR SMR; Q54XJ7; -.
DR STRING; 44689.Q54XJ7; -.
DR PaxDb; 44689-DDB0206267; -.
DR GeneID; 8621766; -.
DR KEGG; ddi:DDB_G0278895; -.
DR dictyBase; DDB_G0278895; cldA.
DR eggNOG; KOG1839; Eukaryota.
DR HOGENOM; CLU_260548_0_0_1; -.
DR InParanoid; Q54XJ7; -.
DR OMA; YEILTHW; -.
DR Proteomes; UP000002195; Chromosome 3.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR GO; GO:0048312; P:intracellular distribution of mitochondria; IBA:GO_Central.
DR GO; GO:0010628; P:positive regulation of gene expression; IMP:dictyBase.
DR CDD; cd00173; SH2; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR033646; CLU-central.
DR InterPro; IPR025697; CLU_dom.
DR InterPro; IPR027523; CLU_prot.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR12601:SF13; CLU DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR12601; EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT EIF-3; 1.
DR Pfam; PF13236; CLU; 1.
DR Pfam; PF12807; eIF3_p135; 1.
DR Pfam; PF00017; SH2; 1.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS51823; CLU; 1.
DR PROSITE; PS50001; SH2; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000002195};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191}.
FT DOMAIN 409..655
FT /note="Clu"
FT /evidence="ECO:0000259|PROSITE:PS51823"
FT DOMAIN 1122..1192
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT REGION 74..123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 207..235
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 294..371
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 798..828
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 928..1001
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1180..1284
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 294..331
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 340..354
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 355..371
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1187..1284
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1313 AA; 145205 MW; 8EB2B682CFF24230 CRC64;
MTTSIVNENN KSKKGIGGGI ELTISPNKMG TNTDINELLL SLPDLHKRFE ENPDDSENFI
KYVILLIFLK KKATSPDSSS SSSSSSSSSS PSTPTPTSSP STRRSSKSST TTTTSTTNNN
NNNNKVSINE VFIYIDKLKK SPLIASDLFE ISCSNPVLVP MGPINRVDHY NPVSIPKFNQ
AVYYNFNGGG DGKVNSQQQQ QSLYGNVDKA STTTTTTTTT TTTTTTNTTT STSKSSISIN
KNINIIGNSR DRSSSAPVSI SKDKNILEIE GLKSSQNTLL PNLSNFQIGN SPPLPSFIHN
NSNNPNNSLQ NKNSSSRGIN NNRSSLNMGS APSPLYVEDD YNPNEDDSDS DNDNYNDNNE
STTTTTTTTT TTTNLKEKAI NSLGNMSDSS GDLHFEKLSI GDLEALKTKI NNSNGLGSLF
KKEEIEKPTE PIRNWSLDFW NALQMDHNCG NENLKRSQKI QAIAEEFVNV ATKHGVTIIQ
EKGLSSGWTI PSYDAGGVAG GLKYLKSGIF FKFAVDCYGI YGGDAFAMKS AGHELKGLMG
YFNCQIDGLF LPLMTLIDYM GYRLIATSQL NIDGDKTLVY GSNDGGETVY NKSEEMEDKM
RKAGEILNLK GHYTGQSDNK TFLYGPCDIE GHITKDNHFV VIDTARVFPP EKPIPGKTGS
HLYTLLRPEL VRSSKMPLSS DAFTKFAGPD RDKNNEEVER SQKRLLNHII PSFVLLMNQK
VKKTKCKNIM ELSQNLMLID SMHREGINVR YLQRLKKTDF HAIDQRLSTI INTEIIARKI
KNRLRSFLRS LPLINNNNNN NSIDNNNNNN NNNNNNNNNN NDDNNPNNNN NINYNINLPD
ICKFLNRMMC ISLLQSCDLD GFSLELLLYR ISQMMGIVFR DGLYKKLGDQ SESIQPDDII
SITPKVKFLH SIPYQQGVSL FHQAISLSKQ QQQQQQPQPQ PQQPTNTSTT TSTSNNTSNN
INNNNNNPDG SNDGSDDNIN NNNNNNNNNN NNNNNNNNLT NSADNLFIQA AEKFKVAIQS
KPDDYEILTH WGILLSMRAR LISNKTYIKA HGKAEIEKLY QSAIEKFQLA VKLKRNHHYA
LFNWAEALRG WAAIRPGTDI AHELEKKAKM KLKEAGVFEK RWFFQTLETQ GVASLLSGAP
AGGFIIRNSN SRPGSFVFSY LSDPHRKILH SIIKSSSHGY HVENLPPRRV SSSSSSSSSS
SSNSSNNIPK SGSSQNLNEL LASSLNSSGS SGGSNISPTN SSTTSPTISR SSSVNNLNQE
LKFNEASTTV PTRNSTSLSG QSPTTTVSYK TLEEFVSDKI KQGYIPITKD WWE
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