ID Y7813_DICDI Reviewed; 477 AA.
AC Q54YP8;
DT 20-APR-2010, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 27-MAR-2024, entry version 87.
DE RecName: Full=TNF receptor-associated factor family protein DDB_G0278133;
GN ORFNames=DDB_G0278133;
OS Dictyostelium discoideum (Social amoeba).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Probable adapter protein and signal transducer that links
CC members of the tumor necrosis factor receptor family to different
CC signaling pathways by association with the receptor cytoplasmic domain
CC and kinases. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- DOMAIN: The MATH/TRAF domain binds to receptor cytoplasmic domains.
CC -!- SIMILARITY: Belongs to the TNF receptor-associated factor family. A
CC subfamily. {ECO:0000305}.
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DR EMBL; AAFI02000023; EAL68239.1; -; Genomic_DNA.
DR RefSeq; XP_642154.1; XM_637062.1.
DR AlphaFoldDB; Q54YP8; -.
DR STRING; 44689.Q54YP8; -.
DR PaxDb; 44689-DDB0204449; -.
DR EnsemblProtists; EAL68239; EAL68239; DDB_G0278133.
DR GeneID; 8621361; -.
DR KEGG; ddi:DDB_G0278133; -.
DR dictyBase; DDB_G0278133; -.
DR eggNOG; ENOG502RBHI; Eukaryota.
DR HOGENOM; CLU_040980_0_0_1; -.
DR InParanoid; Q54YP8; -.
DR OMA; HINDDCE; -.
DR PhylomeDB; Q54YP8; -.
DR PRO; PR:Q54YP8; -.
DR Proteomes; UP000002195; Chromosome 3.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd00121; MATH; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 3.
DR InterPro; IPR002083; MATH/TRAF_dom.
DR InterPro; IPR008974; TRAF-like.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR001293; Znf_TRAF.
DR PANTHER; PTHR10131:SF65; RING FINGER PROTEIN DG17-RELATED; 1.
DR PANTHER; PTHR10131; TNF RECEPTOR ASSOCIATED FACTOR; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF49599; TRAF domain-like; 1.
DR PROSITE; PS50145; ZF_TRAF; 1.
PE 3: Inferred from homology;
KW Coiled coil; Cytoplasm; Metal-binding; Reference proteome; Repeat; Zinc;
KW Zinc-finger.
FT CHAIN 1..477
FT /note="TNF receptor-associated factor family protein
FT DDB_G0278133"
FT /id="PRO_0000393767"
FT DOMAIN 331..463
FT /note="MATH"
FT ZN_FING 45..88
FT /note="RING-type; degenerate"
FT ZN_FING 160..211
FT /note="TRAF-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00207"
FT ZN_FING 212..267
FT /note="TRAF-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00207"
FT COILED 271..326
FT /evidence="ECO:0000255"
SQ SEQUENCE 477 AA; 55551 MW; BBD1E06ECEE7F61D CRC64;
MLDFINLINN INNPTSPTKI TPKVIPIKYE IKDILVDSDE EKYECDICTL ELFIESEPKA
LQCKEGHLAC RRCWERYLST NKQCMTCKTP ISSISELSRN RYLEKEYSNW LNDRLVFCPN
SNENVFRLNM SGLPAINNSN QTLHQDLCNH GAMKFSELQN HYKACESRIL QCNLCLIKFC
SKDSDKHQNE CSKVYSKCEF CNSNILRSSL SDHHKTHCTK YLIECPHCKI MIKRDTITKH
INDDCEEIMI TCSEYLCGKR FTRSKMQIHS LEHSVTKLMN QNEIIKKDNQ NLDQEKKIEE
IKLKLNNLLN NYIQLKNEIA VLKQNSFKEM VYSNKWIIPE YRSFNALYTH KKSKNSNDFQ
VGSHTFYIKI YPNGQAGKQG KFGVFLERKP RYGILLKYMF SFSLLPPEDS TATKVSLGPI
HRVLILLLID FEESRSLSCG TNVFTDSRKV LKDFLNEKGE LEISFSITIQ DEKIIPL
//
