ID NUP43_DICDI Reviewed; 417 AA.
AC Q54Z22;
DT 23-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 27-MAR-2024, entry version 112.
DE RecName: Full=Nuclear pore complex protein nup43;
DE AltName: Full=Nucleoporin nup43;
GN Name=nup43; ORFNames=DDB_G0277955;
OS Dictyostelium discoideum (Social amoeba).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Component of the nuclear pore complex, a complex required for
CC the trafficking across the nuclear membrane. {ECO:0000250}.
CC -!- SUBUNIT: Component of the nuclear pore complex (NPC). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nuclear pore complex {ECO:0000250}.
CC Nucleus membrane {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the NUP43 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAFI02000023; EAL68150.1; -; Genomic_DNA.
DR RefSeq; XP_642030.1; XM_636938.1.
DR AlphaFoldDB; Q54Z22; -.
DR SMR; Q54Z22; -.
DR STRING; 44689.Q54Z22; -.
DR TCDB; 1.I.1.1.5; the nuclear pore complex (npc) family.
DR PaxDb; 44689-DDB0235245; -.
DR EnsemblProtists; EAL68150; EAL68150; DDB_G0277955.
DR GeneID; 8621241; -.
DR KEGG; ddi:DDB_G0277955; -.
DR dictyBase; DDB_G0277955; nup43.
DR eggNOG; KOG4714; Eukaryota.
DR HOGENOM; CLU_659598_0_0_1; -.
DR InParanoid; Q54Z22; -.
DR OMA; QTHIIAT; -.
DR PhylomeDB; Q54Z22; -.
DR PRO; PR:Q54Z22; -.
DR Proteomes; UP000002195; Chromosome 3.
DR GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0031080; C:nuclear pore outer ring; IBA:GO_Central.
DR GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR22652; NUCLEOPORIN NUP43; 1.
DR PANTHER; PTHR22652:SF0; NUCLEOPORIN NUP43; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM00320; WD40; 4.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Membrane; mRNA transport; Nuclear pore complex; Nucleus; Protein transport;
KW Reference proteome; Repeat; Translocation; Transport; WD repeat.
FT CHAIN 1..417
FT /note="Nuclear pore complex protein nup43"
FT /id="PRO_0000393273"
FT REPEAT 13..57
FT /note="WD 1"
FT REPEAT 68..106
FT /note="WD 2"
FT REPEAT 188..227
FT /note="WD 3"
FT REPEAT 231..270
FT /note="WD 4"
FT REPEAT 275..315
FT /note="WD 5"
FT REPEAT 318..358
FT /note="WD 6"
FT REGION 152..188
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 417 AA; 47124 MW; B9384516CEB96D5A CRC64;
MSSVSVHYST HKINKVRFLN RNFHNDTSLF VTGTNHPVLS KNKISVWGLE SRQNSDEIEE
LASVPIDGIV TELKVIEINN KPMIIGSTSK GSIFMYSIFN LPNKFEYIGY DGLLDKKYEN
YNNINNINDT YDTCNLLKER IWFNSSSNNN NVNSNNINNN NYNNNNNNYN NNNNNNNNNN
NNNNNNNNNG SCINSFDISY DQHSLVTVGN DGVMNLLSIE NLIPIYTNRY IDGLSVNVVK
SITSNQIITS GELGRYIKFW DIRSNSSQPV KTIKTQCPRI FSLAIHKDEQ HIIAAGSSDG
QVNLFDIRND YSIDQNKTHN SNVWELSFSK SNPNQLYSCS EDGFIYQYSY NKDNLGGGGM
MTLPNQINNT FDIYSKEVSL LQLPTSIGSI DSFDINSNIN RLICCSTSSQ CLIVKSL
//
