ID Y4613_DICDI Reviewed; 831 AA.
AC Q554L2;
DT 03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 27-MAR-2024, entry version 101.
DE RecName: Full=Probable inactive serine/threonine-protein kinase DDB_G0274613;
GN ORFNames=DDB_G0274613;
OS Dictyostelium discoideum (Social amoeba).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- DOMAIN: The protein kinase domain is predicted to be catalytically
CC inactive.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. CMGC Ser/Thr
CC protein kinase family. {ECO:0000305}.
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DR EMBL; AAFI02000012; EAL70199.1; -; Genomic_DNA.
DR RefSeq; XP_644311.1; XM_639219.1.
DR AlphaFoldDB; Q554L2; -.
DR SMR; Q554L2; -.
DR STRING; 44689.Q554L2; -.
DR PaxDb; 44689-DDB0230051; -.
DR EnsemblProtists; EAL70199; EAL70199; DDB_G0274613.
DR GeneID; 8619739; -.
DR KEGG; ddi:DDB_G0274613; -.
DR dictyBase; DDB_G0274613; -.
DR eggNOG; KOG0660; Eukaryota.
DR HOGENOM; CLU_341439_0_0_1; -.
DR InParanoid; Q554L2; -.
DR OMA; FEFLECS; -.
DR PRO; PR:Q554L2; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IBA:GO_Central.
DR GO; GO:0035556; P:intracellular signal transduction; IBA:GO_Central.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR24055:SF585; INACTIVE SERINE_THREONINE-PROTEIN KINASE DDB_G0274613-RELATED; 1.
DR PANTHER; PTHR24055; MITOGEN-ACTIVATED PROTEIN KINASE; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; Coiled coil; Metal-binding; Nucleotide-binding;
KW Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..831
FT /note="Probable inactive serine/threonine-protein kinase
FT DDB_G0274613"
FT /id="PRO_0000362055"
FT DOMAIN 414..787
FT /note="Protein kinase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT ZN_FING 9..63
FT /note="RING-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT REGION 657..703
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 83..348
FT /evidence="ECO:0000255"
SQ SEQUENCE 831 AA; 95386 MW; 72EB021604771E07 CRC64;
MDPFEFLECS ICSEEVIDFA AIFSSNKKFG DKACKHNFCV SCLTYLMEYN TRNKKALCCP
ICREEFDGFI QNKTSSDLLK QARKLSSAQI FLKNENSKLN EEINLIKNER ENEAIQYRDR
IKQLEDSKSK QVQESTNIKS RIKEMENEIQ SLEQARLLDL QNNQSKFDTQ QQQILTLTQS
YRESQSNYND SNLRANELNN QIQKLYREIE GFKQHAQQQD NYIKDIDSEK QLLQQQLSTI
EQSYDRKQSD LLNNTRLKDL QIAKLSDANQ QLGTSLSKIE AECEHFKKLY KEIQEDANGG
YQKNKNLESA IASLNIELSR SKSVIDSLNT NKRTLEKELE EMKLLYQFGR GTSISSSIAP
PTIINTANKI TNSSYNLINN SIGYFMGSKN YLNDITKPYK GFKIEEKRGN KTSQIHKVSI
GNGCGHFVIK LIPTVSGTNV GNSYSKFIYN SIYSSTLAES EILLFREAML LYKLNHNNIL
KLESITKDES SGKYYSVLSP FVPKDLEFIL AENSQNFGGL GKISPTTLTF SDIKYIVYQL
ISVVHYLHTQ DLVHRDLKPT SILLFDDYQI KLCSFGNAIS VFTNFGNSIT QPTYSNPSSY
SYLSPEYICS VLDKENHSKL SNEIDWKAFD MWSIGCIFLE LIYKKKLFNN LNLDNNNNNN
NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNIES NFNNVNNSQQ QQLYSVLNNI
STYKESAPKN GNLYFKENHN IIIKSKVERD FNGANLPTDA YNLLCALLSF NPTTRIKANQ
AAFHKFFKDE PYYIHDSASV SPNKLEDLSS LLTDRNIKQF LKEKCSNLIQ V
//
