ID Q557A3_DICDI Unreviewed; 709 AA.
AC Q557A3; Q86JS2;
DT 02-MAY-2006, integrated into UniProtKB/TrEMBL.
DT 02-MAY-2006, sequence version 1.
DT 24-JAN-2024, entry version 104.
DE RecName: Full=AMP-dependent synthetase/ligase domain-containing protein {ECO:0008006|Google:ProtNLM};
GN Name=aslO-2 {ECO:0000313|EMBL:EAL70540.1};
GN Synonyms=aslO-1 {ECO:0000313|EMBL:EAL70829.1};
GN ORFNames=DDB_G0273223 {ECO:0000313|EMBL:EAL70829.1}, DDB_G0273699
GN {ECO:0000313|EMBL:EAL70540.1};
OS Dictyostelium discoideum (Social amoeba).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689 {ECO:0000313|EMBL:EAL70540.1, ECO:0000313|Proteomes:UP000002195};
RN [1] {ECO:0000313|EMBL:EAL70540.1, ECO:0000313|Proteomes:UP000002195}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4 {ECO:0000313|EMBL:EAL70540.1,
RC ECO:0000313|Proteomes:UP000002195};
RX PubMed=12097910; DOI=10.1038/nature00847;
RG Dictyostelium Genome Sequencing Consortium;
RA Glockner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2] {ECO:0000313|EMBL:EAL70540.1, ECO:0000313|Proteomes:UP000002195}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4 {ECO:0000313|EMBL:EAL70540.1,
RC ECO:0000313|Proteomes:UP000002195};
RX PubMed=15875012; DOI=10.1038/nature03481;
RG The Dictyostelium discoideum Sequencing Consortium;
RA Eichinger L., Pachebat J.A., Glockner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M., Spiegler S., Tivey A., Sugano S.,
RA White B., Walker D., Woodward J., Winckler T., Tanaka Y., Shaulsky G.,
RA Schleicher M., Weinstock G., Rosenthal A., Cox E.C., Chisholm R.L.,
RA Gibbs R., Loomis W.F., Platzer M., Kay R.R., Williams J., Dear P.H.,
RA Noegel A.A., Barrell B., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [3] {ECO:0000313|EMBL:EAL70540.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=AX4 {ECO:0000313|EMBL:EAL70540.1};
RG The Dictyostelium discoideum Sequencing Consortium;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.-A., Sucgang R.,
RA Song J., Cox E.C., Tunggal B., Szafranski K., Konfortov B.A.,
RA Farbrother P., Bankier A.T., Lehmann R., Hamlin N., Xu Q., Davies R.,
RA Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.,
RA Davis P., Nie X., Kerhornou A., Hemphill L., Bason N., Berriman M.,
RA Desany B., Churcher C., Cooper J., van Driessche N., Cronin A.,
RA Goodhead I., Muzny D., Hall N., Harper D., Lindsay R., Hauser H., James K.,
RA Quiles M., Buchrieser C., Wardroper A., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K., Price C., Ma J., Quail M.,
RA Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Weinstock G.,
RA Sharp S., Just E., Shaulsky G., Simmonds M., Tivey A., White B., Walker D.,
RA Woodward J., Winckler T., Schleicher M., Rosenthal A., Rivero F.,
RA Chisholm R.L., Gibbs R., Loomis W.F., Platzer M., Kay R.R., Williams J.,
RA Dear P.H., Noegel A.A., Barrell B., Kuspa A.;
RL Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAL70540.1}.
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DR EMBL; AAFI02000011; EAL70540.1; -; Genomic_DNA.
DR EMBL; AAFI02000009; EAL70829.1; -; Genomic_DNA.
DR RefSeq; XP_644466.1; XM_639374.1.
DR RefSeq; XP_644784.1; XM_639692.1.
DR AlphaFoldDB; Q557A3; -.
DR SMR; Q557A3; -.
DR STRING; 44689.Q557A3; -.
DR PaxDb; 44689-DDB0231704; -.
DR GeneID; 8618886; -.
DR GeneID; 8619091; -.
DR KEGG; ddi:DDB_G0273223; -.
DR KEGG; ddi:DDB_G0273699; -.
DR dictyBase; DDB_G0273223; aslO-1.
DR dictyBase; DDB_G0273699; aslO-2.
DR eggNOG; KOG1175; Eukaryota.
DR HOGENOM; CLU_000022_3_5_1; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0050218; F:propionate-CoA ligase activity; IBA:GO_Central.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR032387; ACAS_N.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR PANTHER; PTHR43347:SF4; ACETYL-COA SYNETHETASE-RELATED; 1.
DR PANTHER; PTHR43347; ACYL-COA SYNTHETASE; 1.
DR Pfam; PF16177; ACAS_N; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002195}.
FT DOMAIN 10..64
FT /note="Acetyl-coenzyme A synthetase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16177"
FT DOMAIN 74..437
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT REGION 445..498
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 709 AA; 79018 MW; 17FD4F43D24E5AD4 CRC64;
MNRLSEPFNY DKDFSFSNNQ PIEFWDEVAK NFVHWDRMYD KVYSGDEIYP DWFKGGELNT
CYNVLDIHIK NPAKRDQDAL IYECPFLKKT IKLTYYQLYE KVCEFSRALL NLNVSKNDNV
IIYMANTVEA PIAMLSCARI GATYCTLFDG YSVKSLIDRI ETITPKLIIT TNYGISNDEI
ITFTPNLKEA IEQSNFKPNH IIIHNRDDGD YNANLTLKTI IETIPTIPNT LSWYDEIKKF
KENNQSPFYD YIPVDSSHPL YILYTSGTTG NAKAVVRSNG PHLVGVKYTC RCMFLNDEVN
NNNTNSDLIK FFSHSSIGWV TFHGFLYSLL STGNIFIMFE GGICELNQIK YQLWKVIEKH
KVNKFFIGPK SIRLLIKDDP NAEFILSNYN LSSLNTILVG ADVVEKSVAN YIENKLKKSA
SNIYGQTETG NIYLFDFKKS NRSNVSSNSN SSGSGSGSGS GSGSGSGSGS GSGCGSGSGS
GSGSGSGSGS SSGRGNIMVI GQPTPSLKSF ILSEEEEEEV CYNNSDVGGG NSVCSGSSSG
SDSGTSSGKK SLNKNEIGEL VFKLPLPPGF ALTFYKNNEQ FKKLFKTNLL NMEKGYYYFS
GDLAFKDQDN NFTIVSRSDD QIKIKSNKVQ LNTIEISVLK HPLVLECCCI GIKDVEFLTV
PIGILILNNQ NNQNNQNNQN NQNNNPIELK ELEKEINMII SNDIDNHQY
//
