ID Q558Y3_DICDI Unreviewed; 698 AA.
AC Q558Y3;
DT 24-MAY-2005, integrated into UniProtKB/TrEMBL.
DT 24-MAY-2005, sequence version 1.
DT 27-MAR-2024, entry version 97.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EAL71137.1};
GN ORFNames=DDB_G0272999 {ECO:0000313|EMBL:EAL71137.1};
OS Dictyostelium discoideum (Social amoeba).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689 {ECO:0000313|EMBL:EAL71137.1, ECO:0000313|Proteomes:UP000002195};
RN [1] {ECO:0000313|EMBL:EAL71137.1, ECO:0000313|Proteomes:UP000002195}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4 {ECO:0000313|EMBL:EAL71137.1,
RC ECO:0000313|Proteomes:UP000002195};
RX PubMed=12097910; DOI=10.1038/nature00847;
RG Dictyostelium Genome Sequencing Consortium;
RA Glockner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2] {ECO:0000313|EMBL:EAL71137.1, ECO:0000313|Proteomes:UP000002195}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4 {ECO:0000313|EMBL:EAL71137.1,
RC ECO:0000313|Proteomes:UP000002195};
RX PubMed=15875012; DOI=10.1038/nature03481;
RG The Dictyostelium discoideum Sequencing Consortium;
RA Eichinger L., Pachebat J.A., Glockner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M., Spiegler S., Tivey A., Sugano S.,
RA White B., Walker D., Woodward J., Winckler T., Tanaka Y., Shaulsky G.,
RA Schleicher M., Weinstock G., Rosenthal A., Cox E.C., Chisholm R.L.,
RA Gibbs R., Loomis W.F., Platzer M., Kay R.R., Williams J., Dear P.H.,
RA Noegel A.A., Barrell B., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the polycystin family.
CC {ECO:0000256|ARBA:ARBA00007200}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAL71137.1}.
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DR EMBL; AAFI02000008; EAL71137.1; -; Genomic_DNA.
DR RefSeq; XP_644933.1; XM_639841.1.
DR AlphaFoldDB; Q558Y3; -.
DR SMR; Q558Y3; -.
DR STRING; 44689.Q558Y3; -.
DR PaxDb; 44689-DDB0217079; -.
DR GeneID; 8618612; -.
DR KEGG; ddi:DDB_G0272999; -.
DR dictyBase; DDB_G0272999; pkd2.
DR eggNOG; KOG3599; Eukaryota.
DR HOGENOM; CLU_395075_0_0_1; -.
DR InParanoid; Q558Y3; -.
DR OMA; WGRVAMF; -.
DR PhylomeDB; Q558Y3; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0005886; C:plasma membrane; IDA:dictyBase.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0017156; P:calcium-ion regulated exocytosis; IMP:dictyBase.
DR GO; GO:0048870; P:cell motility; IMP:dictyBase.
DR GO; GO:0035590; P:purinergic nucleotide receptor signaling pathway; IMP:dictyBase.
DR GO; GO:1903664; P:regulation of asexual reproduction; IMP:dictyBase.
DR GO; GO:0010810; P:regulation of cell-substrate adhesion; IMP:dictyBase.
DR GO; GO:0034405; P:response to fluid shear stress; IMP:dictyBase.
DR Gene3D; 1.10.287.70; -; 1.
DR InterPro; IPR013122; PKD1_2_channel.
DR InterPro; IPR003915; PKD_2.
DR InterPro; IPR046791; Polycystin_dom.
DR PANTHER; PTHR10877:SF183; AT14535P-RELATED; 1.
DR PANTHER; PTHR10877; POLYCYSTIN FAMILY MEMBER; 1.
DR Pfam; PF08016; PKD_channel; 1.
DR Pfam; PF20519; Polycystin_dom; 1.
DR PRINTS; PR01433; POLYCYSTIN2.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002195};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 46..64
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 274..294
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 315..335
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 367..385
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 406..428
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 472..492
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 88..263
FT /note="Polycystin"
FT /evidence="ECO:0000259|Pfam:PF20519"
FT DOMAIN 275..498
FT /note="Polycystin cation channel PKD1/PKD2"
FT /evidence="ECO:0000259|Pfam:PF08016"
FT REGION 651..698
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 140..149
FT /evidence="ECO:0000256|PIRSR:PIRSR603915-2"
SQ SEQUENCE 698 AA; 80251 MW; AE98665D1F999C57 CRC64;
MNTLKRTVFS QRLEAVKALE NKTREEKATL LAAVETQRNA RLVKDLIIHL VFFVVFVLIV
VLQLNPQSLF IINTSLKNQI LFSQDSQYLE INNPSDFITY LNSTFCESIS DMSLENNDAM
NKIIGNVIRI RTARVKPDSC SNNGFNLTCY SNNYDKDTKD RSPFGPNDMY TYTSNSHGSY
VFGHNQYVWD RSGYYIDIPV SDIKTGVESL IDNGFFDIQT RSVIISFSTL NLNFQSRTSV
FTMLTEWTAS GSVNPYYSIR TYRIQLYMDA LDKFRGFLEV SFFIFILYYF YYFVNEARID
FKLGRFKFYI SNFKNIFDVI NLTLFIASIA LYLAFLGDNS RDLNINSQIQ TTTDYPLYLE
NLGQTALVLY QISAINILLM SFKTFRFLVV HRRLYILWIA ISQSRLQLIT FTIMFCIMML
GFLFSGWLTF GTDIASFNGF VTSLGTLLQF IIGNPPDYEA MSYTNRALGP IYYLLFTIFM
FFILVNMFVA IISDSYQNIS NTFEKKQKTK RYLLTRWERT MKSLLLLFTP NSLDIYDLVL
MFIDQKPGLI ETDGIDPSRF KDEIMIIQPI QRARIKYLDQ IQSAKNTGVT FELKLMGQQV
HKKDLDTWKK EAKIKEKKKF ESIQQNINIL NTKLDLLLQA MNVPQQSIPQ LINGSTGMPQ
SPIINNNNNN GGSIPSSSSN GSINGSNHIN LSGGTNTP
//
