GenomeNet

Database: UniProt
Entry: Q55DW9
LinkDB: Q55DW9
Original site: Q55DW9 
ID   GACZ_DICDI              Reviewed;        1043 AA.
AC   Q55DW9;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   08-MAY-2019, entry version 81.
DE   RecName: Full=Rho GTPase-activating protein gacZ;
DE   AltName: Full=GTPase activating factor for raC protein Z;
GN   Name=gacZ; ORFNames=DDB_G0269496;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Mycetozoa; Dictyostelids; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A.,
RA   Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q.,
RA   Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F.,
RA   Bankier A.T., Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P.,
RA   Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P.,
RA   Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N.,
RA   Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M.,
RA   Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I.,
RA   Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R.,
RA   Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C.,
RA   Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D.,
RA   Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S.,
RA   Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T.,
RA   Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A.,
RA   Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M.,
RA   Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G.,
RA   Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Rho GTPase-activating protein involved in the signal
CC       transduction pathway. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
DR   EMBL; AAFI02000005; EAL72098.1; -; Genomic_DNA.
DR   RefSeq; XP_646012.1; XM_640920.1.
DR   SMR; Q55DW9; -.
DR   STRING; 44689.DDB0233848; -.
DR   PaxDb; Q55DW9; -.
DR   PRIDE; Q55DW9; -.
DR   EnsemblProtists; EAL72098; EAL72098; DDB_G0269496.
DR   GeneID; 8616960; -.
DR   KEGG; ddi:DDB_G0269496; -.
DR   dictyBase; DDB_G0269496; gacZ.
DR   eggNOG; KOG4269; Eukaryota.
DR   eggNOG; ENOG410XPGZ; LUCA.
DR   InParanoid; Q55DW9; -.
DR   OMA; QLDQHVV; -.
DR   Reactome; R-DDI-194840; Rho GTPase cycle.
DR   PRO; PR:Q55DW9; -.
DR   Proteomes; UP000002195; Chromosome 1.
DR   Proteomes; UP000002195; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 1.10.555.10; -; 1.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   InterPro; IPR002893; Znf_MYND.
DR   Pfam; PF00620; RhoGAP; 1.
DR   Pfam; PF01753; zf-MYND; 1.
DR   SMART; SM00324; RhoGAP; 1.
DR   SUPFAM; SSF48350; SSF48350; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
DR   PROSITE; PS01360; ZF_MYND_1; 1.
DR   PROSITE; PS50865; ZF_MYND_2; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Complete proteome; Cytoplasm; GTPase activation;
KW   Metal-binding; Reference proteome; Zinc; Zinc-finger.
FT   CHAIN         1   1043       Rho GTPase-activating protein gacZ.
FT                                /FTId=PRO_0000380223.
FT   DOMAIN      855   1043       Rho-GAP. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00172}.
FT   ZN_FING      71    107       MYND-type. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00134}.
FT   COILED      825    852       {ECO:0000255}.
FT   COMPBIAS     19     34       Poly-Asn.
FT   COMPBIAS     37     42       Poly-Asn.
FT   COMPBIAS     54     62       Poly-Gln.
FT   COMPBIAS    157    168       Poly-Asn.
FT   COMPBIAS    201    213       Gln-rich.
FT   COMPBIAS    244    247       Poly-Ser.
FT   COMPBIAS    256    263       Poly-Ser.
FT   COMPBIAS    269    290       Poly-Asn.
FT   COMPBIAS    371    383       Poly-Asn.
FT   COMPBIAS    458    463       Poly-Ser.
FT   COMPBIAS    467    525       Poly-Asn.
FT   COMPBIAS    551    554       Poly-Asn.
FT   COMPBIAS    580    583       Poly-Ser.
FT   COMPBIAS    653    660       Poly-Asp.
FT   COMPBIAS    757    769       Poly-Gln.
FT   COMPBIAS    817    821       Poly-Asn.
FT   COMPBIAS    827    847       Poly-Asn.
SQ   SEQUENCE   1043 AA;  113652 MW;  B6C7CC1629945E32 CRC64;
     MTTTNTSIFG PRVNNSKFNN NNNNNNNNNN NNNNTSNNNN SNIIKPPQVV QETQQQQQAQ
     QQPLQTNEEV CVICKSKNVQ VCTGCLMVYY CGAEHQNIDW PNHKSLCSGL NRRNDLLDRA
     EKSKDLRKKL QSDIFSSGNR VSNSNNNSSI YSNSTGNINN NNNSNNNNIK GGIGGGAVTN
     SSTVMAPERK SIAISNIKHL QQQIQQTQQT QQQPPPTTTS IPTQPNSSSF NKPTAKKPGT
     SFKSSSSGDN TPINQSPSSS SSSLVSSTNN NNNNNNNNNN NNNINSNSNN MSGSSGGIKA
     LQNQLQNSIN NKPSNTTSNS PNPSPPSSTF VPNSNNNSNS NSSSGSGKSN LNISLKSSTS
     SSPVTSTYLY NNNNSNSNSN SNNSSTETTT CISSNSNNSS NIENSDNTNE ENGMKNIKNK
     LSQINFGAPP PSFKKPTSKV IENEDNNNSN NDGTLKQSSS SDSIYFNNNN NNNNNNNNNN
     NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN SNNNNFDINN SNNIINNKQS
     TCSSIDGLSY NNNNSGSSLK NSVPPTTSNT PPRKRSSGGS SSSNNSNIGS NGNRIGFIKE
     HKKNQSLPDS FVDFYQSNKN QSNGYESLLD NDDNKTRGYG SFNENDDSHE ECDDDDDDDD
     GGGQDGDDGL DGTEFKRGRN RPTGLRTNNN AVFEWESGTI EYSTNNTSQH KKLGVGSRGG
     NSFSKDTQSQ STNSTTTDDH QTGSILNSNS GSSDDLQQQQ TQTQQQQSQL SAGVGRIAGK
     FRMIGGDIKK KAAIVGTLTK NKVSEVTSKS KSSTSVNNNN NDEVDHNENN NNNNNNINNN
     NNNNNNNIEN IIFGIPLEEA VKKSATLHPL IPDVIYKSIE YIREKGIQEE GIFRLSGSAN
     AITLLKNEFD RGVNVDLYQQ LDQHVVSGIL KLYLRQIPET LFTQDFGEEL EELRVGGNSS
     DAISKRIAGS IILLQRLPES NRCILHYLCN LLNAISFEPS TKMGTVNLAI VFAPTLGVSV
     EVMTCLISYY DEIFGIQTYN YNS
//
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