ID Q55EI2_DICDI Unreviewed; 2162 AA.
AC Q55EI2;
DT 24-MAY-2005, integrated into UniProtKB/TrEMBL.
DT 24-MAY-2005, sequence version 1.
DT 27-MAR-2024, entry version 104.
DE SubName: Full=DOCK family protein {ECO:0000313|EMBL:EAL73033.1};
GN Name=zizD {ECO:0000313|EMBL:EAL73033.1};
GN ORFNames=DDB_G0268888 {ECO:0000313|EMBL:EAL73033.1};
OS Dictyostelium discoideum (Social amoeba).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689 {ECO:0000313|EMBL:EAL73033.1, ECO:0000313|Proteomes:UP000002195};
RN [1] {ECO:0000313|EMBL:EAL73033.1, ECO:0000313|Proteomes:UP000002195}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4 {ECO:0000313|EMBL:EAL73033.1,
RC ECO:0000313|Proteomes:UP000002195};
RX PubMed=15875012; DOI=10.1038/nature03481;
RG The Dictyostelium discoideum Sequencing Consortium;
RA Eichinger L., Pachebat J.A., Glockner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M., Spiegler S., Tivey A., Sugano S.,
RA White B., Walker D., Woodward J., Winckler T., Tanaka Y., Shaulsky G.,
RA Schleicher M., Weinstock G., Rosenthal A., Cox E.C., Chisholm R.L.,
RA Gibbs R., Loomis W.F., Platzer M., Kay R.R., Williams J., Dear P.H.,
RA Noegel A.A., Barrell B., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAL73033.1}.
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DR EMBL; AAFI02000004; EAL73033.1; -; Genomic_DNA.
DR RefSeq; XP_647038.1; XM_641946.1.
DR AlphaFoldDB; Q55EI2; -.
DR SMR; Q55EI2; -.
DR STRING; 44689.Q55EI2; -.
DR PaxDb; 44689-DDB0233624; -.
DR GeneID; 8616733; -.
DR KEGG; ddi:DDB_G0268888; -.
DR dictyBase; DDB_G0268888; zizD.
DR eggNOG; KOG1997; Eukaryota.
DR HOGENOM; CLU_231637_0_0_1; -.
DR InParanoid; Q55EI2; -.
DR OMA; YDHYIPL; -.
DR PhylomeDB; Q55EI2; -.
DR Reactome; R-DDI-9013149; RAC1 GTPase cycle.
DR Reactome; R-DDI-9013404; RAC2 GTPase cycle.
DR Reactome; R-DDI-9013423; RAC3 GTPase cycle.
DR Reactome; R-DDI-983231; Factors involved in megakaryocyte development and platelet production.
DR Proteomes; UP000002195; Chromosome 1.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IBA:GO_Central.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd08679; C2_DOCK180_related; 1.
DR CDD; cd11684; DHR2_DOCK; 1.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR InterPro; IPR046770; DOCKER_Lobe_B.
DR InterPro; IPR046773; DOCKER_Lobe_C.
DR PANTHER; PTHR23317:SF109; C2 DOCK-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR23317; DEDICATOR OF CYTOKINESIS DOCK; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 1.
DR Pfam; PF20422; DHR-2_Lobe_B; 1.
DR Pfam; PF20421; DHR-2_Lobe_C; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
PE 3: Inferred from homology;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000002195}.
FT DOMAIN 931..1122
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1724..2162
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 1..55
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 96..148
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 366..439
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 613..652
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 674..708
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 730..807
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12..55
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 681..707
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 742..793
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2162 AA; 242177 MW; 0F3AF83F34FDC74E CRC64;
MSSPDLPPFP PTTTNNNDNS SNSSSGTVPT TFIAGIKSKR SSGSGNNTPT GSPVLSRSAL
ANAVSSNNSS GGGLDSINSL YGNNALTSIT QAFAKSESNH SSPLGSPKLP HTNSSNNIQM
NKSDNGGNNS NNNNNNNNSN GSSINLNNGD QVGLRAFAKK KKGTAPGTSF LNLKAISDEQ
MTLLSNGGVG IGVGGVGSIN GINNNNNNSL TPTRMKWNDF ETEYEKEYEN ILEPLRFPVG
EVVVRRQEKI PRTIFSPTIG IVTSGLEYHV RELIDGFYKD YLIVETKSSM LQSPNQRKPS
IKFGGSGSGL GISNSNSCSD LSSSLSSSNG LNGSSGLGIS SKLFTAGKQL SSRELNYNSI
LPSANSYSSA SSTPSMTSPN LSSGSGSGSS ISISISNSGG GGNSISSNDG SITHRGGGGG
NGNRSSTNGT NGSGLQLHQQ QHFTDPLKEL IPERNGLELL CEVQDLKFSL DVEPFFCSLY
IVDLDKKERI TESFNFHLNS KSLLDSLKIN EDLLSGWSNQ KKCKFNLNKY HPNIYFILRV
HHIFRGDIEK DMKPYYKDHI KDKKKNDALL AQFKCEISEK CQSWGSSDGN SGQILQPFVW
AAYPVFHRPT LSSTPSSMNL TSTPLSPSSL LSAANSSSSS SPSTSADRLP TLSTQNSLNN
LSLLGNFNNV SVTENTNTVS MTPPPTPPPP PPPSIQLPPP PPPSMLNQIS PIELKQQLIQ
QINSLALADD QSLPPMPVSP PLNSANRSSV GSDSGDSIIT TPPSSSSSSS SSPSSNFTLS
PTFNGSGGGV STLSIPQPPP LPLHLGHRRR SSFMNHQSGS SSSLTSTPIG INTKITNTIE
IVNLIPCTPN LTDKTICDML LVDKDLKKLK SQIPGTFTMS ILSKESEEDL RGRISPSLVP
LLPVDTNFKK PNLIREIQDF SETPYPFVEY VNNLYIYPEN VFIKYKNPNI QIQVQLIDDI
SCLKSLKCVY PTTSPYIPAG LWDTITLPAP GLPGPSPTTP YPPLDYCAFS CVSFHDKRPH
FSDEFKIKLP MKITSQHLLF TFFHINIHAK KDVKTSIGYC AVPLCQLSMG PSGNQGGIHF
IKDDYYCAAI SSDMNNLSPK FVNPETSKKE KMPVFTFRTK LVSSVITQDP CLDSFFKGGG
SNEVKSILKI DRVTCVQFFP SILNQLFQIM CTNANEVASQ AFNSILHVIK IVDGFQEKKA
GTEKSRLLTY YSEYLFDYVP DSKNLYEELC RQWVNSINSG VYVKDFRLNW FLLDIMTKSM
ALSLQPTGKL DTDLGRENRF KIEFLENLNK LVLMLIPSQS DGMLVQSWEF FMKFPYFINN
LFPLIDRGFL FNLIYNYITR IDPTNEDLTM VTIKFNFLKI TTDYDHYIPL NFPMLFKSLD
SVSDLNLKFF KRHFLSVLLI TEVEGCLKHN KLATRNQAIQ TLKQLIKKHH YDQRYQAAEI
REKVASIYFP YVLMIVEHYS IIKHQLEARE VQEWLTVFIW ILQYCSRDLL RMWFTKETQK
HQTNLLNLMM MSLESFKDEP SIFEIAILSI EISKYILDDF NEDQMQSNII LLDIIINILQ
KCSSISGVEM LRLIYTIFKD YLVPNYPTLL FQNLNNSYCE IITYDLLRSI NMTDLLDESA
SLFYLLLLKN FQSTKDISKM KIQSTVAISR LVGEIKLENS FNLSSFLMKV RKFVTQQENG
DSVFINQVEE MLNRIDTLMK YSHTINQNKN DPELVSEMYF RISNSYFESP NLRLTWLENL
SKIHSDNENF DEASQCLVHC AYLISRYLIQ TNKFNDILES DFLSICPNIK SELLLPTFDQ
KDSGALFQSN IWSLPYVVEL LEKAIEYLMM GNRYELAIEI HSLISKIHKT KKDYKSLSTS
LSNCQKVCLE LGEKNKETRI YARFYRVGFF GKKFSDEQMD GKEYIYKKPH KCNISVLQNQ
IKNNLQEKFG QDEEIIVLSN AKVDKNSLDP EKVHIQIVSV DPYIVDPQHQ SSAATVDVAL
SQFDQYFNIS QFISEVPFST EGKAIQDDMS KQQKKKTIFS VELAFPYVKN RLEVVSKREI
ILSPIENAIE LIRGRCIKLK EQLDTNPPRI NLLHQILQGS VFPMVNEGPL KICEIFLSPK
TINNFNADHV DQLKKAMEKF IIYCGFTLRL SRSIISVQLQ EFQNMIEEQY KTLKGQINSY
LK
//