ID Q55EX4_DICDI Unreviewed; 746 AA.
AC Q55EX4;
DT 24-MAY-2005, integrated into UniProtKB/TrEMBL.
DT 24-MAY-2005, sequence version 1.
DT 27-MAR-2024, entry version 103.
DE RecName: Full=Pentacotripeptide-repeat region of PRORP domain-containing protein {ECO:0000259|Pfam:PF17177};
GN ORFNames=DDB_G0268718 {ECO:0000313|EMBL:EAL72948.1};
OS Dictyostelium discoideum (Social amoeba).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689 {ECO:0000313|EMBL:EAL72948.1, ECO:0000313|Proteomes:UP000002195};
RN [1] {ECO:0000313|EMBL:EAL72948.1, ECO:0000313|Proteomes:UP000002195}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4 {ECO:0000313|EMBL:EAL72948.1,
RC ECO:0000313|Proteomes:UP000002195};
RX PubMed=15875012; DOI=10.1038/nature03481;
RG The Dictyostelium discoideum Sequencing Consortium;
RA Eichinger L., Pachebat J.A., Glockner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M., Spiegler S., Tivey A., Sugano S.,
RA White B., Walker D., Woodward J., Winckler T., Tanaka Y., Shaulsky G.,
RA Schleicher M., Weinstock G., Rosenthal A., Cox E.C., Chisholm R.L.,
RA Gibbs R., Loomis W.F., Platzer M., Kay R.R., Williams J., Dear P.H.,
RA Noegel A.A., Barrell B., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAL72948.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAFI02000004; EAL72948.1; -; Genomic_DNA.
DR RefSeq; XP_646896.1; XM_641804.1.
DR AlphaFoldDB; Q55EX4; -.
DR SMR; Q55EX4; -.
DR STRING; 44689.Q55EX4; -.
DR PaxDb; 44689-DDB0189978; -.
DR GeneID; 8616581; -.
DR KEGG; ddi:DDB_G0268718; -.
DR dictyBase; DDB_G0268718; ptcE.
DR eggNOG; KOG4197; Eukaryota.
DR HOGENOM; CLU_372759_0_0_1; -.
DR InParanoid; Q55EX4; -.
DR OMA; YPDPPEW; -.
DR Proteomes; UP000002195; Chromosome 1.
DR GO; GO:0043527; C:tRNA methyltransferase complex; IBA:GO_Central.
DR GO; GO:0008176; F:tRNA (guanine(46)-N7)-methyltransferase activity; IBA:GO_Central.
DR GO; GO:0036265; P:RNA (guanine-N7)-methylation; IBA:GO_Central.
DR GO; GO:0030488; P:tRNA methylation; IBA:GO_Central.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR002885; Pentatricopeptide_rpt.
DR InterPro; IPR033443; PPR_long.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR003358; tRNA_(Gua-N-7)_MeTrfase_Trmb.
DR NCBIfam; TIGR00756; PPR; 2.
DR PANTHER; PTHR23417; 3-DEOXY-D-MANNO-OCTULOSONIC-ACID TRANSFERASE/TRNA GUANINE-N 7 - -METHYLTRANSFERASE; 1.
DR PANTHER; PTHR23417:SF14; PPR_LONG DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF02390; Methyltransf_4; 1.
DR Pfam; PF17177; PPR_long; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51375; PPR; 2.
DR PROSITE; PS51625; SAM_MT_TRMB; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002195};
KW tRNA processing {ECO:0000256|ARBA:ARBA00022694}.
FT DOMAIN 244..407
FT /note="Pentacotripeptide-repeat region of PRORP"
FT /evidence="ECO:0000259|Pfam:PF17177"
FT REPEAT 279..313
FT /note="PPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00708"
FT REPEAT 345..379
FT /note="PPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00708"
FT REGION 123..234
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 139..163
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 174..193
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 194..234
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 746 AA; 84524 MW; C05C253A74AF2F55 CRC64;
MDLKRKFGNS LGSTAPTSIG ILGGGGGGVS ITKLIVKNIP KSISKNEIIE NLKKIIQNPS
INITIPITLP PDLIGKVDAD TTISFLSSQN LSQLSIIKNL VNGKTIGDKK VIVDFYDFKK
VIPTPTPIPT PTPPTKTQEE SNKKIKLTNE KPKEKKPKEK KPKTTPPPTT TTPNEPTIAT
ATATTTTTET TETEKTTEIN EEKKVNQKKN KKLNDKKEEK EKEKEVKKEE EPKKESIVRN
NRAVINKITS QMSSCAEAKD YVQLVKAYNY LKKIGAKPDH ITYGVMLNAC VRCQEYKKVK
EVFQDAVKDG NANEVVYTIY VKALCEIDMD ESFATIKGMI ETKPNIRTFN SIFRGCIRSG
DIEITKSLIQ LMKANEIYPD STTIEYLIKI YSHHLMVQEI WDLLGKVYER MQGQISPICF
SRLSLASLLA GDIKSSVKAL GITDDILSKA PRSTQTTHKN KGKLSEKNKI SSSLFERINK
QEINEESDRV RNYLSKMTES RSKIKYHNME SFNRIYFSKN TFKNNVNRSI DQQCKPVTVA
TSPDSTLSSF NGLFNSYKKG GSNFNSNRSL KMEICSGHGH WVTERAGQDL DADWISLEIR
YDRIFQIWSK MILEAIDNLY IVGGDAHGSL KEIIPDNILN EVYINYPNPP VWSGAERLIN
ELFLIEINRC LKKDGTLTIV TDDKDYSDQI IDILTKSKKL LKIYKPVKET YLIQLSEDYG
YSYFNKLWNN GQRVKRYCIY ISKIIN
//
