ID MTPN_DICDI Reviewed; 120 AA.
AC Q55FM5;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 27-MAR-2024, entry version 85.
DE RecName: Full=Myotrophin homolog;
GN Name=mtpn; ORFNames=DDB_G0268038;
OS Dictyostelium discoideum (Social amoeba).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: May regulate NF-kappa-B transcription factor activity. Plays
CC a role in the regulation of the growth of actin filaments. Inhibits the
CC activity of the F-actin-capping protein complex (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the myotrophin family. {ECO:0000305}.
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DR EMBL; AAFI02000003; EAL73472.1; -; Genomic_DNA.
DR RefSeq; XP_647508.1; XM_642416.1.
DR AlphaFoldDB; Q55FM5; -.
DR SMR; Q55FM5; -.
DR STRING; 44689.Q55FM5; -.
DR PaxDb; 44689-DDB0305263; -.
DR EnsemblProtists; EAL73472; EAL73472; DDB_G0268038.
DR GeneID; 8616315; -.
DR KEGG; ddi:DDB_G0268038; -.
DR dictyBase; DDB_G0268038; mtpn.
DR eggNOG; KOG4214; Eukaryota.
DR HOGENOM; CLU_000134_45_7_1; -.
DR InParanoid; Q55FM5; -.
DR OMA; WAIKNGD; -.
DR PhylomeDB; Q55FM5; -.
DR PRO; PR:Q55FM5; -.
DR Proteomes; UP000002195; Chromosome 1.
DR GO; GO:0005737; C:cytoplasm; IDA:dictyBase.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0044877; F:protein-containing complex binding; IDA:dictyBase.
DR GO; GO:0030036; P:actin cytoskeleton organization; IMP:dictyBase.
DR GO; GO:2000813; P:negative regulation of barbed-end actin filament capping; IDA:dictyBase.
DR GO; GO:2000812; P:regulation of barbed-end actin filament capping; IBA:GO_Central.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR PANTHER; PTHR24189; MYOTROPHIN; 1.
DR PANTHER; PTHR24189:SF50; MYOTROPHIN-RELATED; 1.
DR Pfam; PF12796; Ank_2; 1.
DR SMART; SM00248; ANK; 2.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 2.
PE 3: Inferred from homology;
KW ANK repeat; Cytoplasm; Nucleus; Reference proteome; Repeat.
FT CHAIN 1..120
FT /note="Myotrophin homolog"
FT /id="PRO_0000330660"
FT REPEAT 1..31
FT /note="ANK 1"
FT REPEAT 36..65
FT /note="ANK 2"
FT REPEAT 69..98
FT /note="ANK 3"
SQ SEQUENCE 120 AA; 12998 MW; 050C0FAD43785C22 CRC64;
MEEQNDFTWA VKNGDIANVK KSVEAKKDLI SITDGNKRGP CHWAADFNQV EVLEYLISKG
AKFDNTDDYG ITPLLAAVYE GHTGAVELLV KKGANKSVVG PDGQTAYDAA EKADIKALLK
//
