ID Q55FU7_DICDI Unreviewed; 898 AA.
AC Q55FU7;
DT 24-MAY-2005, integrated into UniProtKB/TrEMBL.
DT 24-MAY-2005, sequence version 1.
DT 24-JAN-2024, entry version 68.
DE SubName: Full=GRAM domain-containing protein {ECO:0000313|EMBL:EAL73424.1};
GN ORFNames=DDB_G0267942 {ECO:0000313|EMBL:EAL73424.1};
OS Dictyostelium discoideum (Social amoeba).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689 {ECO:0000313|EMBL:EAL73424.1, ECO:0000313|Proteomes:UP000002195};
RN [1] {ECO:0000313|EMBL:EAL73424.1, ECO:0000313|Proteomes:UP000002195}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4 {ECO:0000313|EMBL:EAL73424.1,
RC ECO:0000313|Proteomes:UP000002195};
RX PubMed=15875012; DOI=10.1038/nature03481;
RG The Dictyostelium discoideum Sequencing Consortium;
RA Eichinger L., Pachebat J.A., Glockner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M., Spiegler S., Tivey A., Sugano S.,
RA White B., Walker D., Woodward J., Winckler T., Tanaka Y., Shaulsky G.,
RA Schleicher M., Weinstock G., Rosenthal A., Cox E.C., Chisholm R.L.,
RA Gibbs R., Loomis W.F., Platzer M., Kay R.R., Williams J., Dear P.H.,
RA Noegel A.A., Barrell B., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAL73424.1}.
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DR EMBL; AAFI02000003; EAL73424.1; -; Genomic_DNA.
DR RefSeq; XP_647436.1; XM_642344.1.
DR AlphaFoldDB; Q55FU7; -.
DR SMR; Q55FU7; -.
DR STRING; 44689.Q55FU7; -.
DR PaxDb; 44689-DDB0302579; -.
DR GeneID; 8616243; -.
DR KEGG; ddi:DDB_G0267942; -.
DR dictyBase; DDB_G0267942; -.
DR eggNOG; KOG1032; Eukaryota.
DR HOGENOM; CLU_322491_0_0_1; -.
DR InParanoid; Q55FU7; -.
DR OMA; CFESKIF; -.
DR Proteomes; UP000002195; Chromosome 1.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR GO; GO:0140268; C:endoplasmic reticulum-plasma membrane contact site; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0032934; F:sterol binding; IBA:GO_Central.
DR GO; GO:0120015; F:sterol transfer activity; IBA:GO_Central.
DR GO; GO:0031152; P:aggregation involved in sorocarp development; IMP:dictyBase.
DR GO; GO:0072752; P:cellular response to rapamycin; IMP:dictyBase.
DR GO; GO:0032366; P:intracellular sterol transport; IBA:GO_Central.
DR GO; GO:0010628; P:positive regulation of gene expression; IMP:dictyBase.
DR CDD; cd13220; PH-GRAM_GRAMDC; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR004182; GRAM.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR031968; VASt.
DR PANTHER; PTHR23319:SF4; AT22714P-RELATED; 1.
DR PANTHER; PTHR23319; UNCHARACTERIZED; 1.
DR Pfam; PF02893; GRAM; 1.
DR Pfam; PF16016; VASt; 1.
DR SMART; SM00568; GRAM; 1.
DR PROSITE; PS51778; VAST; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002195};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 854..872
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 493..660
FT /note="VASt"
FT /evidence="ECO:0000259|PROSITE:PS51778"
FT REGION 1..147
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 277..345
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 397..419
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 433..457
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 665..695
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 716..815
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..90
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 91..119
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 126..140
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 281..345
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 735..815
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 898 AA; 100403 MW; 4E9E4F4984F9192E CRC64;
MASLPNNSSG SVMISPNQGP ISHDSNNFSS SSPISSPYLI QNGGPQSPTV FSPIGSTSPK
THNTLNNSNN NNNNNGHFSP PTTSSSDNDH SINKLKTRSH SSEDLKSISS DEKKKKLFVT
PKLIAPSKKN GSSSSDEPPV SKTIEGRMKS EPFTKKFKLP STEILLHDYS AALFRQILLH
GRIYLFTNHI CFESKIFGIK TSEVIPIKDV IQIKKKSRFT VGIEIITSEN VKYSFASFVS
RDKTYKDLLE VWKDVTGETH EDASSLSIDD DIEDEISNNE LDNHNNNQQQ QINNNNNNNV
NNVQQQQQQQ QQQQNGNYNS NINNEPQQQL HQSQQQPSQQ QTPLTSSIVK EDMTNINNNS
GNSVNNTLTN SQIKNIQQQQ QQQQQQQQQQ QQQQQQQQQQ QQNQQNNNSD GSGSNDSSTT
AIPVVGIVAA STITSSSSST TMTSSSTTTT TTQPLTTIKE IEKDPLDEIY GGVEQYLSKD
QQPQSILESQ SSDFQEILSD NFNVSVVNFY RALYSDRCNF VHSYHVKRGD MNVNVKPWTF
RERFGTIREV EYVAPVSSPI GPDKTRIQET QRYQLTRKKL IVETDTIMLD IPYGDHFRIE
AKWEVTETSQ DTCRLSISLT VRFVKKTWFK SKIETTTVKE TKTSFDKWVQ LAKVEVQKML
QVKPLPSASS STATNTTNNN KVVNHHNGAG SLTPTILIPS LNKSMDKNEM VARLKQDDER
LESPKPHHTR SRSRQHLISS SSQVNSTSPP PNPMISSNNN NNNSNNSIGN IVNSTSNSSN
SLQSQISPPI LPNSPFNLTN NGADNNTNST NISSDSIKST FEKKNNNLEK VSDESGKFIL
KTPFGVLSFG SSQLSILVIC SLLFILYSYM FMKILTLSSK IDTMESIFKD LINKNLNK
//
