ID LRC14_RAT Reviewed; 493 AA.
AC Q569B5;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 10-MAY-2005, sequence version 1.
DT 24-JAN-2024, entry version 112.
DE RecName: Full=Leucine-rich repeat-containing protein 14 {ECO:0000250|UniProtKB:Q15048};
GN Name=Lrrc14 {ECO:0000312|RGD:1560202};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway;
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Spleen;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Negatively regulates Toll-like receptor-mediated NF-kappa-B
CC signaling by disrupting IKK core complex formation through interaction
CC with IKBKB. {ECO:0000250|UniProtKB:Q15048}.
CC -!- SUBUNIT: Interacts with IKBKB; disrupts IKBKB-IKBKG interaction
CC preventing I-kappa-B-kinase (IKK) core complex formation and leading to
CC a decrease of IKBKB phosphorylation and NF-kappaB activation. Interacts
CC with CHUK. {ECO:0000250|UniProtKB:Q15048}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q15048}.
CC -!- SIMILARITY: Belongs to the PRAME family. LRRC14 subfamily.
CC {ECO:0000305}.
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DR EMBL; CH473950; EDM15941.1; -; Genomic_DNA.
DR EMBL; CH473950; EDM15942.1; -; Genomic_DNA.
DR EMBL; BC092583; AAH92583.1; -; mRNA.
DR RefSeq; NP_001019525.1; NM_001024354.1.
DR RefSeq; XP_006241924.1; XM_006241862.3.
DR RefSeq; XP_006241927.1; XM_006241865.2.
DR RefSeq; XP_017450542.1; XM_017595053.1.
DR AlphaFoldDB; Q569B5; -.
DR SMR; Q569B5; -.
DR STRING; 10116.ENSRNOP00000069176; -.
DR PhosphoSitePlus; Q569B5; -.
DR PaxDb; 10116-ENSRNOP00000021673; -.
DR Ensembl; ENSRNOT00065052378; ENSRNOP00065043071; ENSRNOG00065030366.
DR GeneID; 500900; -.
DR KEGG; rno:500900; -.
DR UCSC; RGD:1560202; rat.
DR AGR; RGD:1560202; -.
DR CTD; 9684; -.
DR RGD; 1560202; Lrrc14.
DR VEuPathDB; HostDB:ENSRNOG00000016128; -.
DR eggNOG; ENOG502QWSJ; Eukaryota.
DR HOGENOM; CLU_039635_0_1_1; -.
DR InParanoid; Q569B5; -.
DR OrthoDB; 5344588at2759; -.
DR PhylomeDB; Q569B5; -.
DR TreeFam; TF332708; -.
DR Reactome; R-RNO-9758274; Regulation of NF-kappa B signaling.
DR PRO; PR:Q569B5; -.
DR Proteomes; UP000002494; Chromosome 7.
DR Proteomes; UP000234681; Chromosome 7.
DR Bgee; ENSRNOG00000016128; Expressed in pancreas and 20 other cell types or tissues.
DR ExpressionAtlas; Q569B5; baseline and differential.
DR Genevisible; Q569B5; RN.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0019900; F:kinase binding; ISO:RGD.
DR GO; GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; ISS:UniProtKB.
DR GO; GO:0034122; P:negative regulation of toll-like receptor signaling pathway; ISS:UniProtKB.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR14224:SF9; LEUCINE-RICH REPEAT-CONTAINING PROTEIN 14; 1.
DR PANTHER; PTHR14224; SIMILAR TO PREFERENTIALLY EXPRESSED ANTIGEN IN MELANOMA-LIKE 3; 1.
DR Pfam; PF13516; LRR_6; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Leucine-rich repeat; Reference proteome; Repeat.
FT CHAIN 1..493
FT /note="Leucine-rich repeat-containing protein 14"
FT /id="PRO_0000343682"
FT REPEAT 111..146
FT /note="LRR 1; degenerate"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 194..218
FT /note="LRR 2; degenerate"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 219..246
FT /note="LRR 3; degenerate"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 247..282
FT /note="LRR 4; degenerate"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 283..307
FT /note="LRR 5"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 308..339
FT /note="LRR 6"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 340..360
FT /note="LRR 7"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 364..391
FT /note="LRR 8"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
FT REPEAT 392..416
FT /note="LRR 9"
FT /evidence="ECO:0000250|UniProtKB:Q3UWY1"
SQ SEQUENCE 493 AA; 54915 MW; 6810AE5070F45B08 CRC64;
MHTLVFLSTR QVLQCQPAAC QALPLLPREL FPLLFKVAFM DKKTAVLREL VHTWPFPLLS
FQQLLQECAH CSRALLQERL STESMQAVIL GLTARIHARE AEAGTQPVCR KHTLRVLDMT
GLLDDGVEQD PGTMSMWDCT AAVARTCIAQ QQVGTAKPGL SPVPVEIRVD LRVNRASYTF
LREALQSSVD SLLRLCCRDL RAEDLPMRNT VALLQLLDAG CLRRIDLRFN NLGLRGLSVI
IPHVARFQHL ASLRLHYVHG DSRQPSVDGE DNFRYFLAQM GRFICLRELS IGSSLLSGRL
DQLLSTLQRP LESLELAFCA LLPEDLRFLA QSSHAAHLKK LDLSGNDLSG NQLTPFQGLL
QAVAATLLHL ELTECQIADA QLLATLPTLT RCASLRYLGL YGNPLSMAGL KELLRDSVIQ
AELRTVVHPF PVDCYEGLPW PPPASVLLEA SINEEKFARV EAELHQLLLA SGRAHVLWTT
DIYGRLAADY FNL
//
