ID Q57U57_TRYB2 Unreviewed; 1298 AA.
AC Q57U57; D6XMG7;
DT 10-MAY-2005, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2005, sequence version 1.
DT 27-MAR-2024, entry version 105.
DE RecName: Full=adenylate cyclase {ECO:0000256|ARBA:ARBA00012201};
DE EC=4.6.1.1 {ECO:0000256|ARBA:ARBA00012201};
DE AltName: Full=ATP pyrophosphate-lyase {ECO:0000256|ARBA:ARBA00032597};
DE AltName: Full=Adenylyl cyclase {ECO:0000256|ARBA:ARBA00032637};
GN Name=Tb08.6H23.130 {ECO:0000313|EMBL:AAZ13547.1};
GN ORFNames=Tb927.8.7860 {ECO:0000313|EMBL:AAX70861.1};
OS Trypanosoma brucei brucei (strain 927/4 GUTat10.1).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX NCBI_TaxID=185431 {ECO:0000313|EMBL:AAX70861.1, ECO:0000313|Proteomes:UP000008524};
RN [1] {ECO:0000313|EMBL:AAZ13547.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=927/4 GUTat10.1 {ECO:0000313|EMBL:AAZ13547.1};
RX PubMed=16020724; DOI=10.1126/science.1112181;
RA El-Sayed N.M., Myler P.J., Blandin G., Berriman M., Crabtree J.,
RA Aggarwal G., Caler E., Renauld H., Worthey E.A., Hertz-Fowler C.,
RA Ghedin E., Peacock C., Bartholomeu D.C., Haas B.J., Tran A.N.,
RA Wortman J.R., Alsmark U.C., Angiuoli S., Anupama A., Badger J.,
RA Bringaud F., Cadag E., Carlton J.M., Cerqueira G.C., Creasy T.,
RA Delcher A.L., Djikeng A., Embley T.M., Hauser C., Ivens A.C.,
RA Kummerfeld S.K., Pereira-Leal J.B., Nilsson D., Peterson J., Salzberg S.L.,
RA Shallom J., Silva J.C., Sundaram J., Westenberger S., White O.,
RA Melville S.E., Donelson J.E., Andersson B., Stuart K.D., Hall N.;
RT "Comparative genomics of trypanosomatid parasitic protozoa.";
RL Science 309:404-409(2005).
RN [2] {ECO:0000313|EMBL:AAZ13547.1, ECO:0000313|Proteomes:UP000008524}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=927/4 GUTat10.1 {ECO:0000313|EMBL:AAZ13547.1,
RC ECO:0000313|Proteomes:UP000008524};
RX PubMed=16020726; DOI=10.1126/science.1112642;
RA Berriman M., Ghedin E., Hertz-Fowler C., Blandin G., Renauld H.,
RA Bartholomeu D.C., Lennard N.J., Caler E., Hamlin N.E., Haas B., Bohme U.,
RA Hannick L., Aslett M.A., Shallom J., Marcello L., Hou L., Wickstead B.,
RA Alsmark U.C., Arrowsmith C., Atkin R.J., Barron A.J., Bringaud F.,
RA Brooks K., Carrington M., Cherevach I., Chillingworth T.J., Churcher C.,
RA Clark L.N., Corton C.H., Cronin A., Davies R.M., Doggett J., Djikeng A.,
RA Feldblyum T., Field M.C., Fraser A., Goodhead I., Hance Z., Harper D.,
RA Harris B.R., Hauser H., Hostetler J., Ivens A., Jagels K., Johnson D.,
RA Johnson J., Jones K., Kerhornou A.X., Koo H., Larke N., Landfear S.,
RA Larkin C., Leech V., Line A., Lord A., Macleod A., Mooney P.J., Moule S.,
RA Martin D.M., Morgan G.W., Mungall K., Norbertczak H., Ormond D., Pai G.,
RA Peacock C.S., Peterson J., Quail M.A., Rabbinowitsch E., Rajandream M.A.,
RA Reitter C., Salzberg S.L., Sanders M., Schobel S., Sharp S., Simmonds M.,
RA Simpson A.J., Tallon L., Turner C.M., Tait A., Tivey A.R., Van Aken S.,
RA Walker D., Wanless D., Wang S., White B., White O., Whitehead S.,
RA Woodward J., Wortman J., Adams M.D., Embley T.M., Gull K., Ullu E.,
RA Barry J.D., Fairlamb A.H., Opperdoes F., Barrell B.G., Donelson J.E.,
RA Hall N., Fraser C.M., Melville S.E., El-Sayed N.M.;
RT "The genome of the African trypanosome Trypanosoma brucei.";
RL Science 309:416-422(2005).
RN [3] {ECO:0000313|EMBL:AAX70861.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=GUTat10.1 {ECO:0000313|EMBL:AAX70861.1};
RA Ghedin E., Blandin G., Bartholomeu D., Caler E., Haas B., Hannick L.,
RA Shallom J., Hou L., Djikeng A., Feldblyum T., Hostetler J., Johnson J.,
RA Jones K., Koo H.L., Larkin C., Pai G., Peterson J., Khalak H.G.,
RA Salzberg S., Simpson A.J., Tallon L., Van Aken S., Wanless D., White O.,
RA Wortman J., Fraser C.M., El-Sayed N.M.A.;
RT ".";
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:AAZ13547.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=927/4 GUTat10.1 {ECO:0000313|EMBL:AAZ13547.1};
RA Ghedin E., Blandin G., Bartholomeu D., Caler E., Haas B., Hannick L.,
RA Shallom J., Hou L., Djikeng A., Feldblyum T., Hostetler J., Johnson J.,
RA Jones K., Koo H.L., Larkin C., Pai G., Peterson J., Khalak H.G.,
RA Salzberg S., Simpson A.J., Tallon L., Van Aken S., Wanless D., White O.,
RA Wortman J., Fraser C.M., El-Sayed N.M.A.;
RT "Sequencing, closure, and annotation of Trypanosoma brucei chromosomes 2
RT through 8.";
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Could act as a receptor for an unknown ligand.
CC {ECO:0000256|ARBA:ARBA00002708}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP = 3',5'-cyclic AMP + diphosphate; Xref=Rhea:RHEA:15389,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58165; EC=4.6.1.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001593};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-3 family.
CC {ECO:0000256|ARBA:ARBA00005381}.
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DR EMBL; AC159456; AAX70861.1; -; Genomic_DNA.
DR EMBL; CP000071; AAZ13547.1; -; Genomic_DNA.
DR RefSeq; XP_847613.1; XM_842520.1.
DR AlphaFoldDB; Q57U57; -.
DR STRING; 185431.Q57U57; -.
DR PaxDb; 5691-AAZ13547; -.
DR GeneID; 3659798; -.
DR KEGG; tbr:Tb927.8.7860; -.
DR VEuPathDB; TriTrypDB:Tb927.8.7860; -.
DR eggNOG; KOG0618; Eukaryota.
DR InParanoid; Q57U57; -.
DR OMA; NRTTYIN; -.
DR OrthoDB; 1698689at2759; -.
DR Proteomes; UP000008524; Chromosome 8.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004016; F:adenylate cyclase activity; ISM:GeneDB.
DR GO; GO:0006171; P:cAMP biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0035556; P:intracellular signal transduction; ISM:GeneDB.
DR CDD; cd07556; Nucleotidyl_cyc_III; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR43081; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC-RELATED; 1.
DR PANTHER; PTHR43081:SF1; PH-SENSITIVE ADENYLATE CYCLASE RV1264; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 2.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE 3: Inferred from homology;
KW cAMP biosynthesis {ECO:0000256|ARBA:ARBA00022998};
KW Lyase {ECO:0000313|EMBL:AAX70861.1}; Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:AAX70861.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008524};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 53..73
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 205..224
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 884..904
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 928..1082
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
SQ SEQUENCE 1298 AA; 144356 MW; 4986F8B5281782F4 CRC64;
MLQFLLISPC CLQYCCLLSL LSLFSHFSSL RLTNSSSQVT SVMASFMRLV TPLGAAVACS
HLLMVVLPLL LLIPGLCADK DCNSSSVTVR VYNLLYSSDI SKTTYEPVIA GFNASLHAHN
DDLPANVCIE VEHVHARSDE DYVSYLKNKI DGDAAVQNKS ELPIVLGPVG DETTLHLTRE
LEKFEIVAFS PFTGSSDVRV WKKSLYFLTA SPIAQVLALI RYAVSQLRLQ RLGFMYLKGV
SFGDKEYKLT LKVMSIMGRK LCGVFELDSS TDGRASDDDF EAAWKRFAPT MPQGVIVFGS
PIEDTKRFLM KFLGSNELRG AYILIPSMLQ YVIINSWMKE LAVKNFVPER VILTGPSPLA
NDNEYIAVRK FQTVMGKYLE TNGKLNGHNY EKGHFYDHRT DGELMVHGWI VGEVLWRTLG
SRESLKNRTT YINSLYNQRR YVIDDLVIGD FGGECEGKAG QRGAACKCNQ GGNVVYMKRM
GTDRNLHPVK EGVVTLASSR CYTNLLQLYA PLNGIMFRLE DNPLAQRITE EYRDGASLVV
GKGQLGQGDR FFLHELNSTS SATKHNMLEE VKERVVTAVF GVVDDALLSM TDMTFIDPIP
LSPRLKHPGR NALHLSPTIE QQIFVMVERV VVPNSWGSVH AIVRSSDARG IKSVLRKTFW
ALGGSLGAFD EVTDGESVKS LLPHSGFVLV IGLTEADITA IAEHLDNHRE VRVFALFFDV
ALLYSEFVKV FKKHPQAAER LLFATSLPHW ADNNTTSETV QEFHRDVGNE SKWTPLALLG
YATARAMESV VLQMGRVNSE ELINTIFSQS VIVADDMWYG PFEDSCSNSR WSSAKDCIVN
YGATHISVWS MARVLNPSVP PVRGVATPSI RYYKDGLNMT EEEFIGTIVG TILCLIALVL
IVMLMRKCMR GDTRDNENAP RELTDPVTLI FTDIESSTAQ WAAHPELMPD AVATHHRLIR
TLISKYGCYE VKTVGDSFMI ACKSPFAATQ LACDMQRCFL EHDWKTDVFD TSYREFERQR
AEDDGDYVPP TGHLDPDVYS RLWNGLRVRV GIHTGLCDIR HDEVTKGYDF YGRTSNMAAR
TESIANGGQV LLTRPTYLSL SASEREQLNV TALGDVPLRG VPKPVEMYQL NAVPGRTFTT
LRLDHEVADD EDTSVSCSDG SSIGAVLSDA AYQVVACVEA LLGAFPTAQR KKLLMPFCNR
WGVSLPYNVS DTWDATTCRN VTRLLAARVG RVVDFGTKNT HDSVQFSERR SGTFPSRLAA
AVDLVSIPST STCIQSSCSI IYMNVPDDDD TSKYSPKH
//
