ID Q57UW8_TRYB2 Unreviewed; 1014 AA.
AC Q57UW8; D6XLL8;
DT 10-MAY-2005, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2005, sequence version 1.
DT 27-MAR-2024, entry version 119.
DE SubName: Full=Kinesin, putative {ECO:0000313|EMBL:AAX70596.1};
GN Name=Tb08.4A8.540 {ECO:0000313|EMBL:AAZ13248.1};
GN ORFNames=Tb927.8.4840 {ECO:0000313|EMBL:AAX70596.1};
OS Trypanosoma brucei brucei (strain 927/4 GUTat10.1).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX NCBI_TaxID=185431 {ECO:0000313|EMBL:AAX70596.1, ECO:0000313|Proteomes:UP000008524};
RN [1] {ECO:0000313|EMBL:AAZ13248.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=927/4 GUTat10.1 {ECO:0000313|EMBL:AAZ13248.1};
RX PubMed=16020724; DOI=10.1126/science.1112181;
RA El-Sayed N.M., Myler P.J., Blandin G., Berriman M., Crabtree J.,
RA Aggarwal G., Caler E., Renauld H., Worthey E.A., Hertz-Fowler C.,
RA Ghedin E., Peacock C., Bartholomeu D.C., Haas B.J., Tran A.N.,
RA Wortman J.R., Alsmark U.C., Angiuoli S., Anupama A., Badger J.,
RA Bringaud F., Cadag E., Carlton J.M., Cerqueira G.C., Creasy T.,
RA Delcher A.L., Djikeng A., Embley T.M., Hauser C., Ivens A.C.,
RA Kummerfeld S.K., Pereira-Leal J.B., Nilsson D., Peterson J., Salzberg S.L.,
RA Shallom J., Silva J.C., Sundaram J., Westenberger S., White O.,
RA Melville S.E., Donelson J.E., Andersson B., Stuart K.D., Hall N.;
RT "Comparative genomics of trypanosomatid parasitic protozoa.";
RL Science 309:404-409(2005).
RN [2] {ECO:0000313|EMBL:AAZ13248.1, ECO:0000313|Proteomes:UP000008524}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=927/4 GUTat10.1 {ECO:0000313|EMBL:AAZ13248.1,
RC ECO:0000313|Proteomes:UP000008524};
RX PubMed=16020726; DOI=10.1126/science.1112642;
RA Berriman M., Ghedin E., Hertz-Fowler C., Blandin G., Renauld H.,
RA Bartholomeu D.C., Lennard N.J., Caler E., Hamlin N.E., Haas B., Bohme U.,
RA Hannick L., Aslett M.A., Shallom J., Marcello L., Hou L., Wickstead B.,
RA Alsmark U.C., Arrowsmith C., Atkin R.J., Barron A.J., Bringaud F.,
RA Brooks K., Carrington M., Cherevach I., Chillingworth T.J., Churcher C.,
RA Clark L.N., Corton C.H., Cronin A., Davies R.M., Doggett J., Djikeng A.,
RA Feldblyum T., Field M.C., Fraser A., Goodhead I., Hance Z., Harper D.,
RA Harris B.R., Hauser H., Hostetler J., Ivens A., Jagels K., Johnson D.,
RA Johnson J., Jones K., Kerhornou A.X., Koo H., Larke N., Landfear S.,
RA Larkin C., Leech V., Line A., Lord A., Macleod A., Mooney P.J., Moule S.,
RA Martin D.M., Morgan G.W., Mungall K., Norbertczak H., Ormond D., Pai G.,
RA Peacock C.S., Peterson J., Quail M.A., Rabbinowitsch E., Rajandream M.A.,
RA Reitter C., Salzberg S.L., Sanders M., Schobel S., Sharp S., Simmonds M.,
RA Simpson A.J., Tallon L., Turner C.M., Tait A., Tivey A.R., Van Aken S.,
RA Walker D., Wanless D., Wang S., White B., White O., Whitehead S.,
RA Woodward J., Wortman J., Adams M.D., Embley T.M., Gull K., Ullu E.,
RA Barry J.D., Fairlamb A.H., Opperdoes F., Barrell B.G., Donelson J.E.,
RA Hall N., Fraser C.M., Melville S.E., El-Sayed N.M.;
RT "The genome of the African trypanosome Trypanosoma brucei.";
RL Science 309:416-422(2005).
RN [3] {ECO:0000313|EMBL:AAX70596.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=GUTat10.1 {ECO:0000313|EMBL:AAX70596.1};
RA Ghedin E., Blandin G., Bartholomeu D., Caler E., Haas B., Hannick L.,
RA Shallom J., Hou L., Djikeng A., Feldblyum T., Hostetler J., Johnson J.,
RA Jones K., Koo H.L., Larkin C., Pai G., Peterson J., Khalak H.G.,
RA Salzberg S., Simpson A.J., Tallon L., Van Aken S., Wanless D., White O.,
RA Wortman J., Fraser C.M., El-Sayed N.M.A.;
RT ".";
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:AAZ13248.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=927/4 GUTat10.1 {ECO:0000313|EMBL:AAZ13248.1};
RA Ghedin E., Blandin G., Bartholomeu D., Caler E., Haas B., Hannick L.,
RA Shallom J., Hou L., Djikeng A., Feldblyum T., Hostetler J., Johnson J.,
RA Jones K., Koo H.L., Larkin C., Pai G., Peterson J., Khalak H.G.,
RA Salzberg S., Simpson A.J., Tallon L., Van Aken S., Wanless D., White O.,
RA Wortman J., Fraser C.M., El-Sayed N.M.A.;
RT "Sequencing, closure, and annotation of Trypanosoma brucei chromosomes 2
RT through 8.";
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Kinesin family. {ECO:0000256|PROSITE-ProRule:PRU00283}.
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DR EMBL; AC159448; AAX70596.1; -; Genomic_DNA.
DR EMBL; CP000071; AAZ13248.1; -; Genomic_DNA.
DR RefSeq; XP_847314.1; XM_842221.1.
DR AlphaFoldDB; Q57UW8; -.
DR STRING; 185431.Q57UW8; -.
DR PaxDb; 5691-AAZ13248; -.
DR GeneID; 3659482; -.
DR KEGG; tbr:Tb927.8.4840; -.
DR VEuPathDB; TriTrypDB:Tb927.8.4840; -.
DR eggNOG; KOG0240; Eukaryota.
DR InParanoid; Q57UW8; -.
DR OMA; YMDMGAS; -.
DR OrthoDB; 162805at2759; -.
DR Proteomes; UP000008524; Chromosome 8.
DR GO; GO:0005737; C:cytoplasm; IDA:GeneDB.
DR GO; GO:0005871; C:kinesin complex; EXP:GeneDB.
DR GO; GO:0005874; C:microtubule; IBA:GO_Central.
DR GO; GO:0005875; C:microtubule associated complex; ISM:GeneDB.
DR GO; GO:0005524; F:ATP binding; ISM:GeneDB.
DR GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR GO; GO:0003774; F:cytoskeletal motor activity; ISM:GeneDB.
DR GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR GO; GO:0003777; F:microtubule motor activity; IBA:GO_Central.
DR GO; GO:0007018; P:microtubule-based movement; IBA:GO_Central.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR InterPro; IPR027640; Kinesin-like_fam.
DR InterPro; IPR019821; Kinesin_motor_CS.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR24115:SF578; KINESIN-LIKE PROTEIN KIFC1; 1.
DR PANTHER; PTHR24115; KINESIN-RELATED; 1.
DR Pfam; PF00225; Kinesin; 1.
DR PRINTS; PR00380; KINESINHEAVY.
DR SMART; SM00129; KISc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00411; KINESIN_MOTOR_1; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU00283};
KW Motor protein {ECO:0000256|PROSITE-ProRule:PRU00283};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU00283};
KW Reference proteome {ECO:0000313|Proteomes:UP000008524}.
FT DOMAIN 7..396
FT /note="Kinesin motor"
FT /evidence="ECO:0000259|PROSITE:PS50067"
FT REGION 982..1014
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 99..106
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00283"
SQ SEQUENCE 1014 AA; 112379 MW; A1FE1B62148379DF CRC64;
MVNSSALVSV GVRVRPLVKG AANPQHVSEF QQKKACAVLS DTTLRVSDGC SVGNGRTVHF
AYDCVFDEDA TQEEVYEALA LSAVENVVSG TNSSLLTYGQ TGSGKTYTIL GVTNPEAANG
ELITSESGVL LRSLQDILNY ASLRRNSSHT VVGISALEIY LEEVRDLLSA GESPAVVQMA
VTKDHVLFSN LEYVPILELD DALRVYQEAS AKRMQRMTFG NDKSSRSHAI FNIEVYQQPI
TTVSTKPLTL PQCLALKEAS QVCPPGTRPI SHTHALFADA SNDLLGDANA PVMYSKLSLV
DLAGSEKPGN VKVNSIGFDE LKKINSSLTA LGSVVHALYE GAAHIPYRNT KLTTVLRDTF
AAPNSHVVLI VTVSPTVLTF DETVSSLHFA NKVKELKVSS TAIRNTNNDL DSPKAGSFHS
SVRCFAELSA DLAIAREKHS FSPPEVIKHV AADRNNLLYD TAFNIRLRDS DARYIGMFTL
CDALKAVASE KETANEEERQ EELRRELCDE MVEEWKNGYM ELHSRLETAS ADDGPLTTDE
WQAWERRLVK EATDYRDTRS MRRQLHQRCK LVATDIEKTD NVITGLEYSE AHLNGGHNGG
AYNDYSGEES THWELGGEWD DEEGEDELSE ISSDVGEAAE LATTCLTMCN LMYRNKQLST
LLEEEQDRYQ SQNEEVLEMW RLSMARAVTD SATTHFNEGG GRNYREVLRS VLGPWTPKGK
ELAAQPFPYW MRVDADIGAN TRSRKKEKGV HQTKYDDPEF LDDVASFMKM GGKVRKFNSD
GTCHSRLIYV DVKSREPRLC WSVVGSLGKE GSFPLCLITS ILLGRVKEDS VGGVCYTSWG
VIHTQHEKDS YGREERVDFV CDSPPEFEAW VIGLSHVTGL WPRFELPMGI SDDGMAFRIG
DRGVNFCREW HVPLAVYAET REQLLSRQRS KGVRLTPGEL RVLVRLDIFR SSAMWLHFRD
EGLVVNPLPV LNCYVGAAEG TNSVPQTSTT AATTPSRTST RHLSLRSAST LGPY
//
