ID Q57YT7_TRYB2 Unreviewed; 748 AA.
AC Q57YT7; D6XMB8;
DT 10-MAY-2005, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2005, sequence version 1.
DT 27-MAR-2024, entry version 109.
DE SubName: Full=Trans-sialidase, putative {ECO:0000313|EMBL:AAX69221.1};
GN Name=Tb08.10K10.270 {ECO:0000313|EMBL:AAZ13498.1};
GN ORFNames=Tb927.8.7350 {ECO:0000313|EMBL:AAX69221.1};
OS Trypanosoma brucei brucei (strain 927/4 GUTat10.1).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX NCBI_TaxID=185431 {ECO:0000313|EMBL:AAX69221.1, ECO:0000313|Proteomes:UP000008524};
RN [1] {ECO:0000313|EMBL:AAZ13498.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=927/4 GUTat10.1 {ECO:0000313|EMBL:AAZ13498.1};
RX PubMed=16020724; DOI=10.1126/science.1112181;
RA El-Sayed N.M., Myler P.J., Blandin G., Berriman M., Crabtree J.,
RA Aggarwal G., Caler E., Renauld H., Worthey E.A., Hertz-Fowler C.,
RA Ghedin E., Peacock C., Bartholomeu D.C., Haas B.J., Tran A.N.,
RA Wortman J.R., Alsmark U.C., Angiuoli S., Anupama A., Badger J.,
RA Bringaud F., Cadag E., Carlton J.M., Cerqueira G.C., Creasy T.,
RA Delcher A.L., Djikeng A., Embley T.M., Hauser C., Ivens A.C.,
RA Kummerfeld S.K., Pereira-Leal J.B., Nilsson D., Peterson J., Salzberg S.L.,
RA Shallom J., Silva J.C., Sundaram J., Westenberger S., White O.,
RA Melville S.E., Donelson J.E., Andersson B., Stuart K.D., Hall N.;
RT "Comparative genomics of trypanosomatid parasitic protozoa.";
RL Science 309:404-409(2005).
RN [2] {ECO:0000313|EMBL:AAZ13498.1, ECO:0000313|Proteomes:UP000008524}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=927/4 GUTat10.1 {ECO:0000313|EMBL:AAZ13498.1,
RC ECO:0000313|Proteomes:UP000008524};
RX PubMed=16020726; DOI=10.1126/science.1112642;
RA Berriman M., Ghedin E., Hertz-Fowler C., Blandin G., Renauld H.,
RA Bartholomeu D.C., Lennard N.J., Caler E., Hamlin N.E., Haas B., Bohme U.,
RA Hannick L., Aslett M.A., Shallom J., Marcello L., Hou L., Wickstead B.,
RA Alsmark U.C., Arrowsmith C., Atkin R.J., Barron A.J., Bringaud F.,
RA Brooks K., Carrington M., Cherevach I., Chillingworth T.J., Churcher C.,
RA Clark L.N., Corton C.H., Cronin A., Davies R.M., Doggett J., Djikeng A.,
RA Feldblyum T., Field M.C., Fraser A., Goodhead I., Hance Z., Harper D.,
RA Harris B.R., Hauser H., Hostetler J., Ivens A., Jagels K., Johnson D.,
RA Johnson J., Jones K., Kerhornou A.X., Koo H., Larke N., Landfear S.,
RA Larkin C., Leech V., Line A., Lord A., Macleod A., Mooney P.J., Moule S.,
RA Martin D.M., Morgan G.W., Mungall K., Norbertczak H., Ormond D., Pai G.,
RA Peacock C.S., Peterson J., Quail M.A., Rabbinowitsch E., Rajandream M.A.,
RA Reitter C., Salzberg S.L., Sanders M., Schobel S., Sharp S., Simmonds M.,
RA Simpson A.J., Tallon L., Turner C.M., Tait A., Tivey A.R., Van Aken S.,
RA Walker D., Wanless D., Wang S., White B., White O., Whitehead S.,
RA Woodward J., Wortman J., Adams M.D., Embley T.M., Gull K., Ullu E.,
RA Barry J.D., Fairlamb A.H., Opperdoes F., Barrell B.G., Donelson J.E.,
RA Hall N., Fraser C.M., Melville S.E., El-Sayed N.M.;
RT "The genome of the African trypanosome Trypanosoma brucei.";
RL Science 309:416-422(2005).
RN [3] {ECO:0000313|EMBL:AAX69221.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=GUTat10.1 {ECO:0000313|EMBL:AAX69221.1};
RA Ghedin E., Blandin G., Bartholomeu D., Caler E., Haas B., Hannick L.,
RA Shallom J., Hou L., Djikeng A., Feldblyum T., Hostetler J., Johnson J.,
RA Jones K., Koo H.L., Larkin C., Pai G., Peterson J., Khalak H.G.,
RA Salzberg S., Simpson A.J., Tallon L., Van Aken S., Wanless D., White O.,
RA Wortman J., Fraser C.M., El-Sayed N.M.A.;
RT ".";
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:AAZ13498.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=927/4 GUTat10.1 {ECO:0000313|EMBL:AAZ13498.1};
RA Ghedin E., Blandin G., Bartholomeu D., Caler E., Haas B., Hannick L.,
RA Shallom J., Hou L., Djikeng A., Feldblyum T., Hostetler J., Johnson J.,
RA Jones K., Koo H.L., Larkin C., Pai G., Peterson J., Khalak H.G.,
RA Salzberg S., Simpson A.J., Tallon L., Van Aken S., Wanless D., White O.,
RA Wortman J., Fraser C.M., El-Sayed N.M.A.;
RT "Sequencing, closure, and annotation of Trypanosoma brucei chromosomes 2
RT through 8.";
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; AC159404; AAX69221.1; -; Genomic_DNA.
DR EMBL; CP000071; AAZ13498.1; -; Genomic_DNA.
DR RefSeq; XP_847564.1; XM_842471.1.
DR AlphaFoldDB; Q57YT7; -.
DR SMR; Q57YT7; -.
DR STRING; 185431.Q57YT7; -.
DR CAZy; GH33; Glycoside Hydrolase Family 33.
DR PaxDb; 5691-AAZ13498; -.
DR GeneID; 3659740; -.
DR KEGG; tbr:Tb927.8.7350; -.
DR VEuPathDB; TriTrypDB:Tb927.8.7350; -.
DR InParanoid; Q57YT7; -.
DR OMA; KSAFWEM; -.
DR OrthoDB; 128436at2759; -.
DR Proteomes; UP000008524; Chromosome 8.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0004308; F:exo-alpha-sialidase activity; ISM:GeneDB.
DR GO; GO:0006689; P:ganglioside catabolic process; IBA:GO_Central.
DR GO; GO:0009313; P:oligosaccharide catabolic process; IBA:GO_Central.
DR CDD; cd15482; Sialidase_non-viral; 1.
DR Gene3D; 2.120.10.10; -; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR011040; Sialidase.
DR InterPro; IPR026856; Sialidase_fam.
DR InterPro; IPR036278; Sialidase_sf.
DR InterPro; IPR008377; Sialidase_trypan.
DR PANTHER; PTHR10628; SIALIDASE; 1.
DR PANTHER; PTHR10628:SF25; SIALIDASE-1; 1.
DR Pfam; PF13859; BNR_3; 1.
DR PRINTS; PR01803; TCSIALIDASE.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF50939; Sialidases; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000008524};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..748
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010139679"
FT DOMAIN 85..418
FT /note="Sialidase"
FT /evidence="ECO:0000259|Pfam:PF13859"
SQ SEQUENCE 748 AA; 81289 MW; 16DC7D3DAEF47B03 CRC64;
MASYMLLLVA IVWHCCSVLV VDAKEGTTRE MFLGGGLWVV NEGCLSVGKD PKSTYRGSRR
CILEPKDTSP NIRKEGMKDV HSFRIPSLIE VDGVIIGIAD CRYTSSEDFA FIDTVARYSA
DGGRTWKTEI IFENARVNKD HSRVVDPTVV VKNNTVFVLV GRYNNSKTWW PLMNDGDDWD
ILMYKGTVQK TVDESGNASA TIVWKDPQYL KSLLGTVGKI NGRSLIQYLG GVGNGIVTPN
GTVVFPVQIL NTENYLAAMI LYSDDDGKTW EFSKGATPIG TTESSIVWWG ERLLLNGRTD
RPQSNVDAGY RKVFESSDMG ATWVESLGTI SRVIGNSPER NQPGSSGSSI KVTFDDVPVM
LVTQPKNIHG KWIRDRLQLW LTDGNRVFFV GQISVGDDSS PYSSLLYTKT GELHCLYEQI
VDSGVNIYLT HLVDELELIR STVRLWKAQD RLLAGTCSSD VTDETTCTGI PTAGLVGLLA
GPAVGTVWSD AYQCVNASVG GAAVIDDGLQ LSGKNDSSVS WPVSEQGQDQ RYHFANTHFT
LVVTVQLAEI TQNETSLVGF VTHDGQTSKY ITLSLVKDVC RHGAGQVSGA VEDEQSPGTN
GIHQVALTLS AGKVFAHLDG KHLPDMDTIV TGAGKLLNIS RFFVGHPGVQ DVAAGDGVVV
KNVLLYNRQL SGSELRSLYL NNNVIAVSQL SPEGRSPSLL KDIAEGIGNE MNENCASLKL
VVISDGGVRV HRLLYLLMGL GLLQLLSA
//
