ID Q57Z66_TRYB2 Unreviewed; 833 AA.
AC Q57Z66; D6XGR3;
DT 10-MAY-2005, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2005, sequence version 1.
DT 24-JAN-2024, entry version 78.
DE RecName: Full=Atg6 BARA domain-containing protein {ECO:0000259|Pfam:PF04111};
GN Name=Tb05.27M3.370 {ECO:0000313|EMBL:AAZ11440.1};
GN ORFNames=Tb927.5.3270 {ECO:0000313|EMBL:AAX79567.1};
OS Trypanosoma brucei brucei (strain 927/4 GUTat10.1).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX NCBI_TaxID=185431 {ECO:0000313|EMBL:AAX79567.1, ECO:0000313|Proteomes:UP000008524};
RN [1] {ECO:0000313|EMBL:AAX79567.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=GUTat10.1 {ECO:0000313|EMBL:AAX79567.1};
RA El-Sayed N.M., Khalak H., Adams M.D.;
RL Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AAZ11440.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=927/4 GUTat10.1 {ECO:0000313|EMBL:AAZ11440.1};
RX PubMed=16020724; DOI=10.1126/science.1112181;
RA El-Sayed N.M., Myler P.J., Blandin G., Berriman M., Crabtree J.,
RA Aggarwal G., Caler E., Renauld H., Worthey E.A., Hertz-Fowler C.,
RA Ghedin E., Peacock C., Bartholomeu D.C., Haas B.J., Tran A.N.,
RA Wortman J.R., Alsmark U.C., Angiuoli S., Anupama A., Badger J.,
RA Bringaud F., Cadag E., Carlton J.M., Cerqueira G.C., Creasy T.,
RA Delcher A.L., Djikeng A., Embley T.M., Hauser C., Ivens A.C.,
RA Kummerfeld S.K., Pereira-Leal J.B., Nilsson D., Peterson J., Salzberg S.L.,
RA Shallom J., Silva J.C., Sundaram J., Westenberger S., White O.,
RA Melville S.E., Donelson J.E., Andersson B., Stuart K.D., Hall N.;
RT "Comparative genomics of trypanosomatid parasitic protozoa.";
RL Science 309:404-409(2005).
RN [3] {ECO:0000313|EMBL:AAZ11440.1, ECO:0000313|Proteomes:UP000008524}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=927/4 GUTat10.1 {ECO:0000313|EMBL:AAZ11440.1,
RC ECO:0000313|Proteomes:UP000008524};
RX PubMed=16020726; DOI=10.1126/science.1112642;
RA Berriman M., Ghedin E., Hertz-Fowler C., Blandin G., Renauld H.,
RA Bartholomeu D.C., Lennard N.J., Caler E., Hamlin N.E., Haas B., Bohme U.,
RA Hannick L., Aslett M.A., Shallom J., Marcello L., Hou L., Wickstead B.,
RA Alsmark U.C., Arrowsmith C., Atkin R.J., Barron A.J., Bringaud F.,
RA Brooks K., Carrington M., Cherevach I., Chillingworth T.J., Churcher C.,
RA Clark L.N., Corton C.H., Cronin A., Davies R.M., Doggett J., Djikeng A.,
RA Feldblyum T., Field M.C., Fraser A., Goodhead I., Hance Z., Harper D.,
RA Harris B.R., Hauser H., Hostetler J., Ivens A., Jagels K., Johnson D.,
RA Johnson J., Jones K., Kerhornou A.X., Koo H., Larke N., Landfear S.,
RA Larkin C., Leech V., Line A., Lord A., Macleod A., Mooney P.J., Moule S.,
RA Martin D.M., Morgan G.W., Mungall K., Norbertczak H., Ormond D., Pai G.,
RA Peacock C.S., Peterson J., Quail M.A., Rabbinowitsch E., Rajandream M.A.,
RA Reitter C., Salzberg S.L., Sanders M., Schobel S., Sharp S., Simmonds M.,
RA Simpson A.J., Tallon L., Turner C.M., Tait A., Tivey A.R., Van Aken S.,
RA Walker D., Wanless D., Wang S., White B., White O., Whitehead S.,
RA Woodward J., Wortman J., Adams M.D., Embley T.M., Gull K., Ullu E.,
RA Barry J.D., Fairlamb A.H., Opperdoes F., Barrell B.G., Donelson J.E.,
RA Hall N., Fraser C.M., Melville S.E., El-Sayed N.M.;
RT "The genome of the African trypanosome Trypanosoma brucei.";
RL Science 309:416-422(2005).
RN [4] {ECO:0000313|EMBL:AAX79567.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=GUTat10.1 {ECO:0000313|EMBL:AAX79567.1};
RA Ghedin E., Blandin G., Bartholomeu D., Caler E., Haas B., Hannick L.,
RA Shallom J., Hou L., Djikeng A., Feldblyum T., Hostetler J., Johnson J.,
RA Jones K., Koo H.L., Larkin C., Pai G., Peterson J., Khalak H.G.,
RA Salzberg S., Simpson A.J., Tallon L., Van Aken S., Wanless D., White O.,
RA Wortman J., Fraser C.M., El-Sayed N.M.A.;
RT ".";
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|EMBL:AAZ11440.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=927/4 GUTat10.1 {ECO:0000313|EMBL:AAZ11440.1};
RA Ghedin E., Blandin G., Bartholomeu D., Caler E., Haas B., Hannick L.,
RA Shallom J., Hou L., Djikeng A., Feldblyum T., Hostetler J., Johnson J.,
RA Jones K., Koo H.L., Larkin C., Pai G., Peterson J., Khalak H.G.,
RA Salzberg S., Simpson A.J., Tallon L., Van Aken S., Wanless D., White O.,
RA Wortman J., Fraser C.M., El-Sayed N.M.A.;
RT "Sequencing, closure, and annotation of Trypanosoma brucei chromosomes 2
RT through 8.";
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the beclin family.
CC {ECO:0000256|ARBA:ARBA00005965}.
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DR EMBL; AC113585; AAX79567.1; -; Genomic_DNA.
DR EMBL; CP000068; AAZ11440.1; -; Genomic_DNA.
DR RefSeq; XP_844999.1; XM_839906.1.
DR AlphaFoldDB; Q57Z66; -.
DR STRING; 185431.Q57Z66; -.
DR PaxDb; 5691-AAZ11440; -.
DR GeneID; 3657434; -.
DR KEGG; tbr:Tb927.5.3270; -.
DR VEuPathDB; TriTrypDB:Tb927.5.3270; -.
DR eggNOG; ENOG502S84P; Eukaryota.
DR InParanoid; Q57Z66; -.
DR OMA; FVYQYEW; -.
DR OrthoDB; 125209at2759; -.
DR Proteomes; UP000008524; Chromosome 5.
DR GO; GO:0000407; C:phagophore assembly site; IBA:GO_Central.
DR GO; GO:0034271; C:phosphatidylinositol 3-kinase complex, class III, type I; IBA:GO_Central.
DR GO; GO:0034272; C:phosphatidylinositol 3-kinase complex, class III, type II; IBA:GO_Central.
DR GO; GO:0000045; P:autophagosome assembly; IBA:GO_Central.
DR GO; GO:0006995; P:cellular response to nitrogen starvation; IBA:GO_Central.
DR GO; GO:0045324; P:late endosome to vacuole transport; IBA:GO_Central.
DR Gene3D; 1.10.418.40; Autophagy protein 6/Beclin 1; 1.
DR InterPro; IPR007243; Atg6/Beclin.
DR InterPro; IPR038274; Atg6/Beclin_C_sf.
DR InterPro; IPR040455; Atg6_BARA.
DR PANTHER; PTHR12768; BECLIN 1; 1.
DR PANTHER; PTHR12768:SF4; BECLIN-1; 1.
DR Pfam; PF04111; APG6; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000008524}.
FT DOMAIN 637..814
FT /note="Atg6 BARA"
FT /evidence="ECO:0000259|Pfam:PF04111"
FT REGION 301..326
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 833 AA; 90623 MW; 3955DB4705F64DA6 CRC64;
MGDGSHPGGS VCALFVCCVC RRSVPLAGQS TVCTMNIPGS AKRIYKHKKP EFLSRAQTNT
DEDVKSAKEC CAAFPVTSQR NERHQQGKVR LHPAVKGSRT TATGKYGALS PSPFTPWSVD
GNSREASQYT ESDCGGASEA STTYGNVKKV AMGRAQITAT LPETFAHQYA WFPKEKNDAY
ISDVWSSVQE GSTVPSSGAL NPSTALASAP CSNILQDRLP IPLASLILST PFPSLNISTP
HIAGIVEAES PGRSGGGAAD GEACNRSNAA NLEECDDSNE YYSMAGSHLS FTFAQMGGGL
QSNESHALRT PSPRPQRSGN APTNVNAELN DVSCSRIGLA RTLTLERTVS CGTISPPPMT
DVYKALLTQF SERLMRQVVH GSTTDLPLCI SCWISALAGQ KDATTIAMKD LAKLMEVAEI
PDELEVQPSG YHVDKSNCKE QQDRQSGVFD LQQQESLERL SIEVDEAESH LAHISWAHLE
VADEMLPDLK AQREETSRKI IEVSIRTTAY QTKAFYEVAE TAAALEKSIQ NMSQSYTLAR
STRATSLAFP INTKGSIGTI ARLRLGKVAP NTPKQTQVVA TPATNKEAVP AISEDKEDSK
DRSDVSCCGA GEFTALTTMQ QQVCLHFTRG LLDKRQGFVS TTEINNACGY LLLLLQHLIE
WHNINTSSVI LHPNGERSTI ELKKMRSAPP DAPNITVDFF IKDNFFSRKT FDKACFGVAS
CVREITVWMG RRLQQLRECV ERSERGDRSE TAANADTRAE VVKHGWVTPS SPPFAIKGEK
VGGLSVRYGE VSDGEWTAAM RNLLDVVHWC VVVSCEVNDL QQMLFERDES SSS
//
