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Database: UniProt
Entry: Q58154
LinkDB: Q58154
Original site: Q58154 
ID   HDRC1_METJA             Reviewed;         194 AA.
AC   Q58154;
DT   16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   16-JAN-2019, entry version 116.
DE   RecName: Full=CoB--CoM heterodisulfide reductase iron-sulfur subunit C 1 {ECO:0000305};
DE            EC=1.8.98.- {ECO:0000305};
GN   Name=hdrC1; OrderedLocusNames=MJ0744;
OS   Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 /
OS   JCM 10045 / NBRC 100440) (Methanococcus jannaschii).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci;
OC   Methanococcales; Methanocaldococcaceae; Methanocaldococcus.
OX   NCBI_TaxID=243232;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX   PubMed=8688087; DOI=10.1126/science.273.5278.1058;
RA   Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D.,
RA   Sutton G.G., Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D.,
RA   Kerlavage A.R., Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I.,
RA   Overbeek R., Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A.,
RA   Scott J.L., Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D.,
RA   Utterback T.R., Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C.,
RA   Cotton M.D., Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M.,
RA   Klenk H.-P., Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
RT   "Complete genome sequence of the methanogenic archaeon, Methanococcus
RT   jannaschii.";
RL   Science 273:1058-1073(1996).
CC   -!- FUNCTION: Part of a complex that catalyzes the reversible
CC       reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme
CC       M) and H-S-CoB (coenzyme B). {ECO:0000250|UniProtKB:Q6LY39}.
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000255|PROSITE-ProRule:PRU00711};
CC       Note=Binds 2 [4Fe-4S] clusters per subunit. {ECO:0000255|PROSITE-
CC       ProRule:PRU00711};
CC   -!- PATHWAY: Cofactor metabolism; coenzyme M-coenzyme B
CC       heterodisulfide reduction; coenzyme B and coenzyme M from coenzyme
CC       M-coenzyme B heterodisulfide: step 1/1.
CC       {ECO:0000250|UniProtKB:Q6LY39}.
CC   -!- SUBUNIT: The heterodisulfide reductase is composed of three
CC       subunits; HdrA, HdrB and HdrC. {ECO:0000250|UniProtKB:Q6LY39}.
CC   -!- SIMILARITY: Belongs to the HdrC family. {ECO:0000305}.
DR   EMBL; L77117; AAB98738.1; -; Genomic_DNA.
DR   PIR; H64392; H64392.
DR   RefSeq; WP_010870249.1; NC_000909.1.
DR   ProteinModelPortal; Q58154; -.
DR   SMR; Q58154; -.
DR   STRING; 243232.MJ_0744; -.
DR   PRIDE; Q58154; -.
DR   EnsemblBacteria; AAB98738; AAB98738; MJ_0744.
DR   GeneID; 1451621; -.
DR   KEGG; mja:MJ_0744; -.
DR   eggNOG; arCOG00964; Archaea.
DR   eggNOG; COG1150; LUCA.
DR   InParanoid; Q58154; -.
DR   KO; K03390; -.
DR   OMA; WLCTTCY; -.
DR   OrthoDB; 102216at2157; -.
DR   PhylomeDB; Q58154; -.
DR   BioCyc; MJAN243232:G1GKE-805-MONOMER; -.
DR   UniPathway; UPA00647; UER00700.
DR   Proteomes; UP000000805; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0051912; F:CoB--CoM heterodisulfide reductase activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0051186; P:cofactor metabolic process; IEA:InterPro.
DR   GO; GO:0015948; P:methanogenesis; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.1060.10; -; 1.
DR   InterPro; IPR017896; 4Fe4S_Fe-S-bd.
DR   InterPro; IPR017900; 4Fe4S_Fe_S_CS.
DR   InterPro; IPR017680; CoB/CoM_hetero-S_Rdtase_csu.
DR   InterPro; IPR009051; Helical_ferredxn.
DR   SUPFAM; SSF46548; SSF46548; 1.
DR   TIGRFAMs; TIGR03290; CoB_CoM_SS_C; 1.
DR   PROSITE; PS00198; 4FE4S_FER_1; 2.
DR   PROSITE; PS51379; 4FE4S_FER_2; 2.
PE   3: Inferred from homology;
KW   4Fe-4S; Complete proteome; Iron; Iron-sulfur; Metal-binding;
KW   Methanogenesis; Oxidoreductase; Reference proteome; Repeat.
FT   CHAIN         1    194       CoB--CoM heterodisulfide reductase iron-
FT                                sulfur subunit C 1.
FT                                /FTId=PRO_0000150073.
FT   DOMAIN       25     55       4Fe-4S ferredoxin-type 1.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00711}.
FT   DOMAIN       67     98       4Fe-4S ferredoxin-type 2.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00711}.
FT   METAL        35     35       Iron-sulfur 1 (4Fe-4S).
FT                                {ECO:0000255|PROSITE-ProRule:PRU00711}.
FT   METAL        38     38       Iron-sulfur 1 (4Fe-4S).
FT                                {ECO:0000255|PROSITE-ProRule:PRU00711}.
FT   METAL        41     41       Iron-sulfur 1 (4Fe-4S).
FT                                {ECO:0000255|PROSITE-ProRule:PRU00711}.
FT   METAL        45     45       Iron-sulfur 2 (4Fe-4S).
FT                                {ECO:0000255|PROSITE-ProRule:PRU00711}.
FT   METAL        79     79       Iron-sulfur 2 (4Fe-4S).
FT                                {ECO:0000255|PROSITE-ProRule:PRU00711}.
FT   METAL        82     82       Iron-sulfur 2 (4Fe-4S).
FT                                {ECO:0000255|PROSITE-ProRule:PRU00711}.
FT   METAL        85     85       Iron-sulfur 2 (4Fe-4S).
FT                                {ECO:0000255|PROSITE-ProRule:PRU00711}.
FT   METAL        89     89       Iron-sulfur 1 (4Fe-4S).
FT                                {ECO:0000255|PROSITE-ProRule:PRU00711}.
SQ   SEQUENCE   194 AA;  22016 MW;  8871167DFD0C83AD CRC64;
     MVIYAQKDIS NDFIKEIIKT GEILGEGHVS SFKACYQCGT CTGSCPSGRI TAFRTRKLIR
     YAQFGMKSAI IDSEDLWMCT TCYECYERCP RTVKITDIIK VLRNIAAREG KMAEAHKKTA
     LYVFKTGHAV PINDQIKKAR KEIGLTEIPP TTHKYPDALE VVRGIMKDLR FCDMVGICTE
     TMQLKPVEWK DMSE
//
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