ID Q581Q1_TRYB2 Unreviewed; 429 AA.
AC Q581Q1; D6XFB6;
DT 10-MAY-2005, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2005, sequence version 1.
DT 27-MAR-2024, entry version 119.
DE SubName: Full=Ribosomal protein L3, mitochondrial, putative {ECO:0000313|EMBL:AAX79918.1};
GN Name=Tb04.2L9.1340 {ECO:0000313|EMBL:AAZ10771.1};
GN ORFNames=Tb927.4.1800 {ECO:0000313|EMBL:AAX79918.1};
OS Trypanosoma brucei brucei (strain 927/4 GUTat10.1).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX NCBI_TaxID=185431 {ECO:0000313|EMBL:AAX79918.1, ECO:0000313|Proteomes:UP000008524};
RN [1] {ECO:0000313|EMBL:AAX79918.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=GUTat10.1 {ECO:0000313|EMBL:AAX79918.1};
RA El-Sayed N.M., Khalak H., Adams M.D.;
RL Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AAZ10771.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=927/4 GUTat10.1 {ECO:0000313|EMBL:AAZ10771.1};
RX PubMed=16020724; DOI=10.1126/science.1112181;
RA El-Sayed N.M., Myler P.J., Blandin G., Berriman M., Crabtree J.,
RA Aggarwal G., Caler E., Renauld H., Worthey E.A., Hertz-Fowler C.,
RA Ghedin E., Peacock C., Bartholomeu D.C., Haas B.J., Tran A.N.,
RA Wortman J.R., Alsmark U.C., Angiuoli S., Anupama A., Badger J.,
RA Bringaud F., Cadag E., Carlton J.M., Cerqueira G.C., Creasy T.,
RA Delcher A.L., Djikeng A., Embley T.M., Hauser C., Ivens A.C.,
RA Kummerfeld S.K., Pereira-Leal J.B., Nilsson D., Peterson J., Salzberg S.L.,
RA Shallom J., Silva J.C., Sundaram J., Westenberger S., White O.,
RA Melville S.E., Donelson J.E., Andersson B., Stuart K.D., Hall N.;
RT "Comparative genomics of trypanosomatid parasitic protozoa.";
RL Science 309:404-409(2005).
RN [3] {ECO:0000313|EMBL:AAZ10771.1, ECO:0000313|Proteomes:UP000008524}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=927/4 GUTat10.1 {ECO:0000313|EMBL:AAZ10771.1,
RC ECO:0000313|Proteomes:UP000008524};
RX PubMed=16020726; DOI=10.1126/science.1112642;
RA Berriman M., Ghedin E., Hertz-Fowler C., Blandin G., Renauld H.,
RA Bartholomeu D.C., Lennard N.J., Caler E., Hamlin N.E., Haas B., Bohme U.,
RA Hannick L., Aslett M.A., Shallom J., Marcello L., Hou L., Wickstead B.,
RA Alsmark U.C., Arrowsmith C., Atkin R.J., Barron A.J., Bringaud F.,
RA Brooks K., Carrington M., Cherevach I., Chillingworth T.J., Churcher C.,
RA Clark L.N., Corton C.H., Cronin A., Davies R.M., Doggett J., Djikeng A.,
RA Feldblyum T., Field M.C., Fraser A., Goodhead I., Hance Z., Harper D.,
RA Harris B.R., Hauser H., Hostetler J., Ivens A., Jagels K., Johnson D.,
RA Johnson J., Jones K., Kerhornou A.X., Koo H., Larke N., Landfear S.,
RA Larkin C., Leech V., Line A., Lord A., Macleod A., Mooney P.J., Moule S.,
RA Martin D.M., Morgan G.W., Mungall K., Norbertczak H., Ormond D., Pai G.,
RA Peacock C.S., Peterson J., Quail M.A., Rabbinowitsch E., Rajandream M.A.,
RA Reitter C., Salzberg S.L., Sanders M., Schobel S., Sharp S., Simmonds M.,
RA Simpson A.J., Tallon L., Turner C.M., Tait A., Tivey A.R., Van Aken S.,
RA Walker D., Wanless D., Wang S., White B., White O., Whitehead S.,
RA Woodward J., Wortman J., Adams M.D., Embley T.M., Gull K., Ullu E.,
RA Barry J.D., Fairlamb A.H., Opperdoes F., Barrell B.G., Donelson J.E.,
RA Hall N., Fraser C.M., Melville S.E., El-Sayed N.M.;
RT "The genome of the African trypanosome Trypanosoma brucei.";
RL Science 309:416-422(2005).
RN [4] {ECO:0000313|EMBL:AAX79918.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=GUTat10.1 {ECO:0000313|EMBL:AAX79918.1};
RA Ghedin E., Blandin G., Bartholomeu D., Caler E., Haas B., Hannick L.,
RA Shallom J., Hou L., Djikeng A., Feldblyum T., Hostetler J., Johnson J.,
RA Jones K., Koo H.L., Larkin C., Pai G., Peterson J., Khalak H.G.,
RA Salzberg S., Simpson A.J., Tallon L., Van Aken S., Wanless D., White O.,
RA Wortman J., Fraser C.M., El-Sayed N.M.A.;
RT ".";
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|EMBL:AAZ10771.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=927/4 GUTat10.1 {ECO:0000313|EMBL:AAZ10771.1};
RA Ghedin E., Blandin G., Bartholomeu D., Caler E., Haas B., Hannick L.,
RA Shallom J., Hou L., Djikeng A., Feldblyum T., Hostetler J., Johnson J.,
RA Jones K., Koo H.L., Larkin C., Pai G., Peterson J., Khalak H.G.,
RA Salzberg S., Simpson A.J., Tallon L., Van Aken S., Wanless D., White O.,
RA Wortman J., Fraser C.M., El-Sayed N.M.A.;
RT "Sequencing, closure, and annotation of Trypanosoma brucei chromosomes 2
RT through 8.";
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN [6] {ECO:0007829|PDB:4V8M}
RP STRUCTURE BY ELECTRON MICROSCOPY (5.57 ANGSTROMS).
RX PubMed=23395961; DOI=10.1038/nature11872;
RA Hashem Y., des Georges A., Fu J., Buss S.N., Jossinet F., Jobe A.,
RA Zhang Q., Liao H.Y., Grassucci R.A., Bajaj C., Westhof E.,
RA Madison-Antenucci S., Frank J.;
RT "High-resolution cryo-electron microscopy structure of the Trypanosoma
RT brucei ribosome.";
RL Nature 494:385-389(2013).
CC -!- SIMILARITY: Belongs to the universal ribosomal protein uL3 family.
CC {ECO:0000256|ARBA:ARBA00006540, ECO:0000256|RuleBase:RU003905}.
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DR EMBL; AC091702; AAX79918.1; -; Genomic_DNA.
DR EMBL; CP000067; AAZ10771.1; -; Genomic_DNA.
DR RefSeq; XP_844330.1; XM_839237.1.
DR PDB; 4V8M; EM; 5.57 A; Bf=1-429.
DR PDBsum; 4V8M; -.
DR AlphaFoldDB; Q581Q1; -.
DR EMDB; EMD-17208; -.
DR EMDB; EMD-17212; -.
DR IntAct; Q581Q1; 1.
DR STRING; 185431.Q581Q1; -.
DR GeneID; 3656707; -.
DR KEGG; tbr:Tb927.4.1800; -.
DR VEuPathDB; TriTrypDB:Tb927.4.1790; -.
DR VEuPathDB; TriTrypDB:Tb927.4.1800; -.
DR InParanoid; Q581Q1; -.
DR OrthoDB; 20251at2759; -.
DR Proteomes; UP000008524; Chromosome 4.
DR GO; GO:0022625; C:cytosolic large ribosomal subunit; IBA:GO_Central.
DR GO; GO:0005762; C:mitochondrial large ribosomal subunit; IDA:GeneDB.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central.
DR GO; GO:0006412; P:translation; IBA:GO_Central.
DR Gene3D; 3.30.1430.10; -; 1.
DR Gene3D; 4.10.960.10; Ribosomal protein L3, domain 3; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR InterPro; IPR045077; L3_arc_euk.
DR InterPro; IPR044892; Ribosomal_L3_dom_3_arc_sf.
DR InterPro; IPR000597; Ribosomal_uL3.
DR InterPro; IPR019926; Ribosomal_uL3_CS.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR PANTHER; PTHR11363:SF5; 60S RIBOSOMAL PROTEIN L3; 1.
DR PANTHER; PTHR11363; 60S RIBOSOMAL PROTEIN L3-RELATED; 1.
DR Pfam; PF00297; Ribosomal_L3; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR PROSITE; PS00474; RIBOSOMAL_L3; 1.
PE 1: Evidence at protein level;
KW 3D-structure {ECO:0007829|PDB:4V8M};
KW Reference proteome {ECO:0000313|Proteomes:UP000008524};
KW Ribonucleoprotein {ECO:0000256|ARBA:ARBA00023274,
KW ECO:0000256|RuleBase:RU003905};
KW Ribosomal protein {ECO:0000256|ARBA:ARBA00022980,
KW ECO:0000256|RuleBase:RU003905}.
FT REGION 20..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 374..429
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 374..412
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 429 AA; 48692 MW; 4611A853EE77B07B CRC64;
MSHCKFEHPR HGHLGFLPRK RSRQIRGRAR SFPKDDPSQK PHLTSFMVYK AGMTHIVRDV
DRPGSKVNKK EVVEPVTILE APPMVVVGIV GYRQTPVGHK TIGTVWAHHT SVEFRRRFYK
NWKQSAQLAF TKRKQFARTT EGRLAEARTL KAFEKKADII RVVAHTQLRK LRNNRVGVKK
AHVSEIQING GTIAQKIELA KSLLEKEVRI DSVFQQSEAC DVCAVTKGHG FTGVVKRWGV
ACLPRKTHRG LRKVACIGAW HPSRVMYTVA RAGQHGYHHR THLNKKIYQL GRAVSMEPNQ
ATTAYDLTAK TITPMGGFVG YGTVRNDYVM LKGSVAGPRR RVITLRRPMA PQTSRKLTEK
ITLKFIDTSS KIGHGRFQTK KEKSQWYGPL KKDRIRREER LRKERAARAA ERKAKGGATT
TAAPRKSKK
//
