ID Q584D1_TRYB2 Unreviewed; 639 AA.
AC Q584D1; D6XFJ2;
DT 10-MAY-2005, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2005, sequence version 1.
DT 27-MAR-2024, entry version 96.
DE SubName: Full=Cardiolipin synthetase, putative {ECO:0000313|EMBL:AAX79074.1};
DE EC=2.7.8.- {ECO:0000313|EMBL:AAX79074.1};
GN Name=Tb04.1H19.1130 {ECO:0000313|EMBL:AAZ10847.1};
GN ORFNames=Tb927.4.2560 {ECO:0000313|EMBL:AAX79074.1};
OS Trypanosoma brucei brucei (strain 927/4 GUTat10.1).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX NCBI_TaxID=185431 {ECO:0000313|EMBL:AAX79074.1, ECO:0000313|Proteomes:UP000008524};
RN [1] {ECO:0000313|EMBL:AAX79074.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=GUTat10.1 {ECO:0000313|EMBL:AAX79074.1};
RA El-Sayed N.M., Khalak H., Adams M.D.;
RL Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AAZ10847.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=927/4 GUTat10.1 {ECO:0000313|EMBL:AAZ10847.1};
RX PubMed=16020724; DOI=10.1126/science.1112181;
RA El-Sayed N.M., Myler P.J., Blandin G., Berriman M., Crabtree J.,
RA Aggarwal G., Caler E., Renauld H., Worthey E.A., Hertz-Fowler C.,
RA Ghedin E., Peacock C., Bartholomeu D.C., Haas B.J., Tran A.N.,
RA Wortman J.R., Alsmark U.C., Angiuoli S., Anupama A., Badger J.,
RA Bringaud F., Cadag E., Carlton J.M., Cerqueira G.C., Creasy T.,
RA Delcher A.L., Djikeng A., Embley T.M., Hauser C., Ivens A.C.,
RA Kummerfeld S.K., Pereira-Leal J.B., Nilsson D., Peterson J., Salzberg S.L.,
RA Shallom J., Silva J.C., Sundaram J., Westenberger S., White O.,
RA Melville S.E., Donelson J.E., Andersson B., Stuart K.D., Hall N.;
RT "Comparative genomics of trypanosomatid parasitic protozoa.";
RL Science 309:404-409(2005).
RN [3] {ECO:0000313|EMBL:AAZ10847.1, ECO:0000313|Proteomes:UP000008524}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=927/4 GUTat10.1 {ECO:0000313|EMBL:AAZ10847.1,
RC ECO:0000313|Proteomes:UP000008524};
RX PubMed=16020726; DOI=10.1126/science.1112642;
RA Berriman M., Ghedin E., Hertz-Fowler C., Blandin G., Renauld H.,
RA Bartholomeu D.C., Lennard N.J., Caler E., Hamlin N.E., Haas B., Bohme U.,
RA Hannick L., Aslett M.A., Shallom J., Marcello L., Hou L., Wickstead B.,
RA Alsmark U.C., Arrowsmith C., Atkin R.J., Barron A.J., Bringaud F.,
RA Brooks K., Carrington M., Cherevach I., Chillingworth T.J., Churcher C.,
RA Clark L.N., Corton C.H., Cronin A., Davies R.M., Doggett J., Djikeng A.,
RA Feldblyum T., Field M.C., Fraser A., Goodhead I., Hance Z., Harper D.,
RA Harris B.R., Hauser H., Hostetler J., Ivens A., Jagels K., Johnson D.,
RA Johnson J., Jones K., Kerhornou A.X., Koo H., Larke N., Landfear S.,
RA Larkin C., Leech V., Line A., Lord A., Macleod A., Mooney P.J., Moule S.,
RA Martin D.M., Morgan G.W., Mungall K., Norbertczak H., Ormond D., Pai G.,
RA Peacock C.S., Peterson J., Quail M.A., Rabbinowitsch E., Rajandream M.A.,
RA Reitter C., Salzberg S.L., Sanders M., Schobel S., Sharp S., Simmonds M.,
RA Simpson A.J., Tallon L., Turner C.M., Tait A., Tivey A.R., Van Aken S.,
RA Walker D., Wanless D., Wang S., White B., White O., Whitehead S.,
RA Woodward J., Wortman J., Adams M.D., Embley T.M., Gull K., Ullu E.,
RA Barry J.D., Fairlamb A.H., Opperdoes F., Barrell B.G., Donelson J.E.,
RA Hall N., Fraser C.M., Melville S.E., El-Sayed N.M.;
RT "The genome of the African trypanosome Trypanosoma brucei.";
RL Science 309:416-422(2005).
RN [4] {ECO:0000313|EMBL:AAX79074.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=GUTat10.1 {ECO:0000313|EMBL:AAX79074.1};
RA Ghedin E., Blandin G., Bartholomeu D., Caler E., Haas B., Hannick L.,
RA Shallom J., Hou L., Djikeng A., Feldblyum T., Hostetler J., Johnson J.,
RA Jones K., Koo H.L., Larkin C., Pai G., Peterson J., Khalak H.G.,
RA Salzberg S., Simpson A.J., Tallon L., Van Aken S., Wanless D., White O.,
RA Wortman J., Fraser C.M., El-Sayed N.M.A.;
RT ".";
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|EMBL:AAZ10847.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=927/4 GUTat10.1 {ECO:0000313|EMBL:AAZ10847.1};
RA Ghedin E., Blandin G., Bartholomeu D., Caler E., Haas B., Hannick L.,
RA Shallom J., Hou L., Djikeng A., Feldblyum T., Hostetler J., Johnson J.,
RA Jones K., Koo H.L., Larkin C., Pai G., Peterson J., Khalak H.G.,
RA Salzberg S., Simpson A.J., Tallon L., Van Aken S., Wanless D., White O.,
RA Wortman J., Fraser C.M., El-Sayed N.M.A.;
RT "Sequencing, closure, and annotation of Trypanosoma brucei chromosomes 2
RT through 8.";
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; AC079933; AAX79074.1; -; Genomic_DNA.
DR EMBL; CP000067; AAZ10847.1; -; Genomic_DNA.
DR RefSeq; XP_844406.1; XM_839313.1.
DR AlphaFoldDB; Q584D1; -.
DR STRING; 185431.Q584D1; -.
DR PaxDb; 5691-AAZ10847; -.
DR GeneID; 3656785; -.
DR KEGG; tbr:Tb927.4.2560; -.
DR VEuPathDB; TriTrypDB:Tb927.4.2560; -.
DR eggNOG; ENOG502RKKV; Eukaryota.
DR InParanoid; Q584D1; -.
DR OMA; WITTPYY; -.
DR OrthoDB; 7769at2759; -.
DR Proteomes; UP000008524; Chromosome 4.
DR GO; GO:0020023; C:kinetoplast; IDA:GeneDB.
DR GO; GO:0005739; C:mitochondrion; IDA:GeneDB.
DR GO; GO:0008808; F:cardiolipin synthase activity; IMP:GeneDB.
DR GO; GO:0032049; P:cardiolipin biosynthetic process; IMP:GeneDB.
DR GO; GO:0007007; P:inner mitochondrial membrane organization; IMP:GeneDB.
DR GO; GO:0033617; P:mitochondrial cytochrome c oxidase assembly; IMP:GeneDB.
DR GO; GO:0033108; P:mitochondrial respiratory chain complex assembly; IMP:GeneDB.
DR GO; GO:0034551; P:mitochondrial respiratory chain complex III assembly; IMP:GeneDB.
DR GO; GO:0007005; P:mitochondrion organization; IMP:GeneDB.
DR GO; GO:0006119; P:oxidative phosphorylation; IMP:GeneDB.
DR CDD; cd09110; PLDc_CLS_1; 1.
DR CDD; cd09159; PLDc_ybhO_like_2; 1.
DR Gene3D; 3.30.870.10; Endonuclease Chain A; 2.
DR InterPro; IPR025202; PLD-like_dom.
DR InterPro; IPR001736; PLipase_D/transphosphatidylase.
DR PANTHER; PTHR21248; CARDIOLIPIN SYNTHASE; 1.
DR PANTHER; PTHR21248:SF22; PHOSPHOLIPASE D; 1.
DR Pfam; PF00614; PLDc; 1.
DR Pfam; PF13091; PLDc_2; 1.
DR SMART; SM00155; PLDc; 2.
DR SUPFAM; SSF56024; Phospholipase D/nuclease; 2.
DR PROSITE; PS50035; PLD; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000008524};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000313|EMBL:AAX79074.1}.
FT DOMAIN 200..227
FT /note="PLD phosphodiesterase"
FT /evidence="ECO:0000259|PROSITE:PS50035"
FT DOMAIN 535..562
FT /note="PLD phosphodiesterase"
FT /evidence="ECO:0000259|PROSITE:PS50035"
SQ SEQUENCE 639 AA; 73791 MW; 61770A6F909B2FA5 CRC64;
MTFNGRFRAT LRGINIRNAS MTSLSLTGSH AQKQTVLGST PGALGTIPTV ALNGVNPLPR
YRHNLLFGTL SFGDRWDRIQ RRLAVLGRAS TGNVVVPFSD SADAFRRMWE SVDSASDSVL
WQTYICKDDF VGQKTVKKLE EAHRRGCKTE LLYDCGGNIT GRRRLVGDLK KSGANVIEHR
PMWEHFFPYF LRGMKWELSP GIRNHRKILI VDNKLGFCGG LNIGDEYCGT SEGGNGRFRD
THCVVMGPAV MHMREVYEDT KAPKPWKWSL ARWRQIASAT MNLRYLEGMN VKHDYLEPTT
TFVRQGGGVY LRRQMERAER STVRMMERMR WKRQRERLNR CLLTLAKNLR EGQGLVFKAA
TGKGDDVATT DAGSKRNNEV SHGQWKLMKR RIDEYRQRAI KNAEESFFRR LRVVNPSMRL
LEDTSPVAEA EAYGQAHAAV TQVLSCNPHS RDWSIPYAFW QVSKFVHQRL WVTTPYYMPH
RKLMRALQLA ARRGVDVRIL AGSNRTTDPW FMWYASNYIT GMLMASGVRV YEYKGGQVMH
AKTVVADSIW TSIGSYNWDM MSNKNMEICV CHLDHNLALT MEKQFLDDMN VSEEVNYEEY
QRRSLWLRFS SWFFYTALRI AEKFTFRTFW DPDLSSEID
//
