ID Q58CP3_BOVIN Unreviewed; 317 AA.
AC Q58CP3;
DT 26-APR-2005, integrated into UniProtKB/TrEMBL.
DT 26-APR-2005, sequence version 1.
DT 27-MAR-2024, entry version 104.
DE SubName: Full=Interleukin 10 receptor subunit beta {ECO:0000313|Ensembl:ENSBTAP00000025852.6};
DE SubName: Full=Interleukin 10 receptor, beta {ECO:0000313|EMBL:AAX46751.1};
GN Name=IL10RB {ECO:0000313|EMBL:AAX46751.1,
GN ECO:0000313|Ensembl:ENSBTAP00000025852.6,
GN ECO:0000313|VGNC:VGNC:56219};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|EMBL:AAX46751.1};
RN [1] {ECO:0000313|EMBL:AAX46751.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Pooled {ECO:0000313|EMBL:AAX46751.1};
RX PubMed=11282978; DOI=10.1101/gr.170101;
RA Smith T.P., Grosse W.M., Freking B.A., Roberts A.J., Stone R.T., Casas E.,
RA Wray J.E., White J., Cho J., Fahrenkrug S.C., Bennett G.L., Heaton M.P.,
RA Laegreid W.W., Rohrer G.A., Chitko-McKown C.G., Pertea G., Holt I.,
RA Karamycheva S., Liang F., Quackenbush J., Keele J.W.;
RT "Sequence evaluation of four pooled-tissue normalized bovine cDNA libraries
RT and construction of a gene index for cattle.";
RL Genome Res. 11:626-630(2001).
RN [2] {ECO:0000313|EMBL:AAX46751.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Pooled {ECO:0000313|EMBL:AAX46751.1};
RX PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.;
RT "Characterization of 954 bovine full-CDS cDNA sequences.";
RL BMC Genomics 6:166-166(2005).
RN [3] {ECO:0000313|Ensembl:ENSBTAP00000025852.6, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000025852.6,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|Ensembl:ENSBTAP00000025852.6}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000025852.6};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR EMBL; BT021904; AAX46751.1; -; mRNA.
DR RefSeq; NP_001070443.1; NM_001076975.1.
DR STRING; 9913.ENSBTAP00000025852; -.
DR PaxDb; 9913-ENSBTAP00000025852; -.
DR Ensembl; ENSBTAT00000025852.6; ENSBTAP00000025852.6; ENSBTAG00000019404.6.
DR GeneID; 767864; -.
DR KEGG; bta:767864; -.
DR CTD; 3588; -.
DR VEuPathDB; HostDB:ENSBTAG00000019404; -.
DR VGNC; VGNC:56219; IL10RB.
DR GeneTree; ENSGT00940000158231; -.
DR OMA; ASTECDF; -.
DR OrthoDB; 4004685at2759; -.
DR TreeFam; TF332537; -.
DR Reactome; R-BTA-449836; Other interleukin signaling.
DR Reactome; R-BTA-6783783; Interleukin-10 signaling.
DR Reactome; R-BTA-8854691; Interleukin-20 family signaling.
DR Proteomes; UP000009136; Chromosome 1.
DR Bgee; ENSBTAG00000019404; Expressed in neutrophil and 104 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004920; F:interleukin-10 receptor activity; IBA:GO_Central.
DR GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR015373; Interferon/interleukin_rcp_dom.
DR PANTHER; PTHR20859; INTERFERON/INTERLEUKIN RECEPTOR; 1.
DR PANTHER; PTHR20859:SF50; INTERLEUKIN-10 RECEPTOR SUBUNIT BETA; 1.
DR Pfam; PF09294; Interfer-bind; 1.
DR Pfam; PF01108; Tissue_fac; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR PROSITE; PS50853; FN3; 2.
PE 2: Evidence at transcript level;
KW Membrane {ECO:0000256|SAM:Phobius}; Receptor {ECO:0000313|EMBL:AAX46751.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..317
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041158870"
FT TRANSMEM 221..245
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 23..111
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 112..216
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
SQ SEQUENCE 317 AA; 36132 MW; 644770A050366B3B CRC64;
MARSLLSWLG GCLLMSALGM VPPPENVRMN SVNFKNILRW ESPAFPKGNL TFTAQYQSYR
KFQDTCTSIL LTECDFSSLS KYGDHTLRVR AEFADESSEW INITFCPVDD TTIGPPRMQV
EALANSLHVR FFAPRIENEP EPWTMRNIYN SWTYHVRYWK NGSDEKFSIS GQYDFEFLRN
LESQTTYCVQ VRGFLSDRNK AGEWSEPVCE QTTIDETTPS WMVASVLAAS VCAALLLLLG
CFFLLRCVYR KARHAFPPRN SLPQHLKEFM SHPHHSTLLL FSFPLSDENE VFDKLSVITE
VSESCKLNPG AGCGLTT
//
