ID Q58CS5_BOVIN Unreviewed; 740 AA.
AC Q58CS5; F1MZZ4;
DT 26-APR-2005, integrated into UniProtKB/TrEMBL.
DT 26-APR-2005, sequence version 1.
DT 27-MAR-2024, entry version 158.
DE SubName: Full=FGD1 family, member 3 {ECO:0000313|EMBL:AAX46719.1};
DE SubName: Full=FYVE, RhoGEF and PH domain containing 3 {ECO:0000313|Ensembl:ENSBTAP00000009131.4};
GN Name=FGD3 {ECO:0000313|EMBL:AAX46719.1,
GN ECO:0000313|Ensembl:ENSBTAP00000009131.4,
GN ECO:0000313|VGNC:VGNC:28966};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|EMBL:AAX46719.1};
RN [1] {ECO:0000313|EMBL:AAX46719.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Pooled {ECO:0000313|EMBL:AAX46719.1};
RX PubMed=11282978; DOI=10.1101/gr.170101;
RA Smith T.P., Grosse W.M., Freking B.A., Roberts A.J., Stone R.T., Casas E.,
RA Wray J.E., White J., Cho J., Fahrenkrug S.C., Bennett G.L., Heaton M.P.,
RA Laegreid W.W., Rohrer G.A., Chitko-McKown C.G., Pertea G., Holt I.,
RA Karamycheva S., Liang F., Quackenbush J., Keele J.W.;
RT "Sequence evaluation of four pooled-tissue normalized bovine cDNA libraries
RT and construction of a gene index for cattle.";
RL Genome Res. 11:626-630(2001).
RN [2] {ECO:0000313|EMBL:AAX46719.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Pooled {ECO:0000313|EMBL:AAX46719.1};
RX PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.;
RT "Characterization of 954 bovine full-CDS cDNA sequences.";
RL BMC Genomics 6:166-166(2005).
RN [3] {ECO:0000313|Ensembl:ENSBTAP00000009131.4, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000009131.4,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|Ensembl:ENSBTAP00000009131.4}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000009131.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
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DR EMBL; BT021872; AAX46719.1; -; mRNA.
DR RefSeq; NP_001019698.1; NM_001024527.1.
DR STRING; 9913.ENSBTAP00000009131; -.
DR PaxDb; 9913-ENSBTAP00000009131; -.
DR Ensembl; ENSBTAT00000009131.5; ENSBTAP00000009131.4; ENSBTAG00000006939.6.
DR GeneID; 512950; -.
DR KEGG; bta:512950; -.
DR CTD; 89846; -.
DR VEuPathDB; HostDB:ENSBTAG00000006939; -.
DR VGNC; VGNC:28966; FGD3.
DR eggNOG; KOG4424; Eukaryota.
DR GeneTree; ENSGT00940000159597; -.
DR HOGENOM; CLU_011755_1_1_1; -.
DR OMA; RITGEWE; -.
DR TreeFam; TF316247; -.
DR Reactome; R-BTA-193648; NRAGE signals death through JNK.
DR Reactome; R-BTA-416482; G alpha (12/13) signalling events.
DR Reactome; R-BTA-9013148; CDC42 GTPase cycle.
DR Proteomes; UP000009136; Chromosome 8.
DR Bgee; ENSBTAG00000006939; Expressed in neutrophil and 102 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007010; P:cytoskeleton organization; IBA:GO_Central.
DR GO; GO:0046847; P:filopodium assembly; IBA:GO_Central.
DR CDD; cd15740; FYVE_FGD3; 1.
DR CDD; cd13387; PH1_FGD3; 1.
DR CDD; cd13236; PH2_FGD1-4; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR035941; FGD1-4_PH2.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR12673; FACIOGENITAL DYSPLASIA PROTEIN; 1.
DR PANTHER; PTHR12673:SF14; FYVE, RHOGEF AND PH DOMAIN-CONTAINING PROTEIN 3; 1.
DR Pfam; PF01363; FYVE; 1.
DR Pfam; PF00169; PH; 2.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00064; FYVE; 1.
DR SMART; SM00233; PH; 2.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 161..345
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 374..473
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 536..592
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT DOMAIN 620..721
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..154
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 486..545
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..34
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 54..90
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 528..542
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 740 AA; 80674 MW; 44DA5A174972B66A CRC64;
MEPGRGSSTP PAPSATMEEP DAGPNNSSLE QPSTDPGKLP ALPVGPGTHH GELASGSPGS
QASAGDMSSV GEASSSKIPN RDSGIDSPSC SVVSEHFCED SGEAGPGTII KGPHPGTALG
SKSPQEEADS DAGEGSSEEP DPENNPSKVD MDPAKCSEPQ KLLHIAQELL HTEETYVKRL
YLLDQVFCTG LTEAGIPSEV TTGIFSNISS IYRFHGQFLL PELQARITNE WDVNPRLGDI
LQKLAPFLKM YGEYVKNFDR AMELVSTWTQ RSPVFKDTVQ SIQKQELCGN LTLQHHMLEP
VQRVPRYELL LKDYLKRLPE DAPDWKDAER SLELISTAAN HSNAAIRKME KMHKLLEVYE
RLGGEEDIVN PANELIKEGH IQKLSAKNGT TQDRHLFLFN SMILYCVPKL RLMGQKFSVR
EKMDISGLQV QDIVKSGAAH TFIITGKKRS LELQTRTEEE KKEWIQVIQA TIEKHKQNSQ
TFKAFSGSFS QDENSPLTPE PPMMSPSSEV PAVPANSGGG VSGSEPRRGS SKTRRDKEKQ
GCSSCGETFN SITKRKHHCK LCGAVICGKC SEFKAENGRQ SRVCKECFLT QPVAHLNLSL
EEPLEPKQST EKPVAAEPPP SLLCGPLQVS DGGTAWSKAW AAISESDSLE LVLHLHEGSQ
DGQLLHAIPL SGCRVSVLDP AERLDARHVW QLQQAQQSLY LSAPSAELQQ QWLEALSSAA
HRHSSQASLG APQPQAPAAP
//
