ID NMUR2_BOVIN Reviewed; 407 AA.
AC Q58CW4;
DT 06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2005, sequence version 1.
DT 08-NOV-2023, entry version 114.
DE RecName: Full=Neuromedin-U receptor 2;
DE Short=NMU-R2;
GN Name=NMUR2;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT "Characterization of 954 bovine full-CDS cDNA sequences.";
RL BMC Genomics 6:166-166(2005).
CC -!- FUNCTION: Receptor for the neuromedin-U and neuromedin-S neuropeptides.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; BT021833; AAX46680.1; -; mRNA.
DR RefSeq; NP_001030220.1; NM_001035048.1.
DR AlphaFoldDB; Q58CW4; -.
DR SMR; Q58CW4; -.
DR STRING; 9913.ENSBTAP00000014782; -.
DR GlyCosmos; Q58CW4; 3 sites, No reported glycans.
DR PaxDb; 9913-ENSBTAP00000014782; -.
DR GeneID; 507439; -.
DR KEGG; bta:507439; -.
DR CTD; 56923; -.
DR eggNOG; KOG3656; Eukaryota.
DR HOGENOM; CLU_009579_6_5_1; -.
DR InParanoid; Q58CW4; -.
DR OrthoDB; 3471593at2759; -.
DR TreeFam; TF318522; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0001607; F:neuromedin U receptor activity; IEA:InterPro.
DR GO; GO:0008188; F:neuropeptide receptor activity; IBA:GO_Central.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IBA:GO_Central.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR005390; NeuromedU_rcpt.
DR InterPro; IPR005392; NeuromedU_rcpt_2.
DR InterPro; IPR045561; NMU-R2_C.
DR PANTHER; PTHR24243; G-PROTEIN COUPLED RECEPTOR; 1.
DR PANTHER; PTHR24243:SF14; NEUROMEDIN-U RECEPTOR 2; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR Pfam; PF19285; NmU-R2_C_term; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01565; NEUROMEDINUR.
DR PRINTS; PR01567; NEUROMEDNU2R.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..407
FT /note="Neuromedin-U receptor 2"
FT /id="PRO_0000069909"
FT TOPO_DOM 1..47
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 48..68
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 69..79
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 80..100
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 101..120
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 121..139
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 140..162
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 163..183
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 184..211
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 212..232
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 233..262
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 263..283
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 284..298
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 299..319
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 320..407
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 6
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 24
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 191
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 116..201
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 407 AA; 46343 MW; 6C49046C250DBC22 CRC64;
MEKHENVSWM YQQELKDPFK KYLNNTDDYL ALLCGPRRSH LFLPVTAVYA LIFVVGVVGN
LLVCLVILRH QTMKTPTNYY LFSLAVSDLL VLLLGMPLEV YEMWRNYPFL FGPVGCYFKT
ALFETVCFAS ILSVTTVSVE RYVAVLHPFR AKLKSTRGRA LRILGIVWGL SVLFSLPNTS
IHGIKLHYFP NGSIIPGSAT CTVIKPMWIY NFIIQVTSLL FYILPMTVIS VLYYLMGLKL
KKDQHLEADK VTANIQRPSR KSVTKMLFVL VLVFAICWAP FHIDRLFFSF VEEWTEPLAA
VFNLIHVVSG VFFYLSSAVN PIIYNLLSHR FQAAFRTVIP PSCQQQHSHN HSPGPSMQRN
IFLTECHLVE LTEDVAPQFP RQLSVLSSQL PTALCTGQVP RKELAKS
//
