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Database: UniProt
Entry: Q59990
LinkDB: Q59990
Original site: Q59990 
ID   CP120_SYNY3             Reviewed;         444 AA.
AC   Q59990;
DT   14-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   07-OCT-2020, entry version 121.
DE   RecName: Full=Putative cytochrome P450 120;
DE            EC=1.14.-.-;
GN   Name=cyp120; Synonyms=cyp; OrderedLocusNames=slr0574;
OS   Synechocystis sp. (strain PCC 6803 / Kazusa).
OC   Bacteria; Cyanobacteria; Synechococcales; Merismopediaceae; Synechocystis;
OC   unclassified Synechocystis.
OX   NCBI_TaxID=1111708;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 27184 / PCC 6803 / N-1;
RX   PubMed=8590279; DOI=10.1093/dnares/2.4.153;
RA   Kaneko T., Tanaka A., Sato S., Kotani H., Sazuka T., Miyajima N.,
RA   Sugiura M., Tabata S.;
RT   "Sequence analysis of the genome of the unicellular cyanobacterium
RT   Synechocystis sp. strain PCC6803. I. Sequence features in the 1 Mb region
RT   from map positions 64% to 92% of the genome.";
RL   DNA Res. 2:153-166(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PCC 6803 / Kazusa;
RX   PubMed=8905231; DOI=10.1093/dnares/3.3.109;
RA   Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y.,
RA   Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T.,
RA   Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.,
RA   Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT   "Sequence analysis of the genome of the unicellular cyanobacterium
RT   Synechocystis sp. strain PCC6803. II. Sequence determination of the entire
RT   genome and assignment of potential protein-coding regions.";
RL   DNA Res. 3:109-136(1996).
CC   -!- COFACTOR:
CC       Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
CC   -!- SIMILARITY: Belongs to the cytochrome P450 family. {ECO:0000305}.
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DR   EMBL; BA000022; BAA10496.1; -; Genomic_DNA.
DR   PIR; S75761; S75761.
DR   PDB; 2VE3; X-ray; 2.10 A; A/B=1-444.
DR   PDB; 2VE4; X-ray; 2.40 A; A/B=1-444.
DR   PDBsum; 2VE3; -.
DR   PDBsum; 2VE4; -.
DR   SMR; Q59990; -.
DR   STRING; 1148.1001252; -.
DR   PaxDb; Q59990; -.
DR   EnsemblBacteria; BAA10496; BAA10496; BAA10496.
DR   KEGG; syn:slr0574; -.
DR   eggNOG; COG2124; Bacteria.
DR   InParanoid; Q59990; -.
DR   OMA; CPEKFDP; -.
DR   PhylomeDB; Q59990; -.
DR   EvolutionaryTrace; Q59990; -.
DR   Proteomes; UP000001425; Chromosome.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0004497; F:monooxygenase activity; IBA:GO_Central.
DR   GO; GO:0016491; F:oxidoreductase activity; IBA:GO_Central.
DR   GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR   GO; GO:0055114; P:oxidation-reduction process; IBA:GO_Central.
DR   GO; GO:0016125; P:sterol metabolic process; IBA:GO_Central.
DR   Gene3D; 1.10.630.10; -; 1.
DR   InterPro; IPR001128; Cyt_P450.
DR   InterPro; IPR017972; Cyt_P450_CS.
DR   InterPro; IPR002401; Cyt_P450_E_grp-I.
DR   InterPro; IPR036396; Cyt_P450_sf.
DR   Pfam; PF00067; p450; 1.
DR   PRINTS; PR00463; EP450I.
DR   PRINTS; PR00385; P450.
DR   SUPFAM; SSF48264; SSF48264; 1.
DR   PROSITE; PS00086; CYTOCHROME_P450; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Heme; Iron; Metal-binding; Monooxygenase; Oxidoreductase;
KW   Reference proteome.
FT   CHAIN           1..444
FT                   /note="Putative cytochrome P450 120"
FT                   /id="PRO_0000052272"
FT   METAL           391
FT                   /note="Iron (heme axial ligand)"
FT                   /evidence="ECO:0000250"
FT   TURN            21..23
FT                   /evidence="ECO:0000244|PDB:2VE3"
FT   HELIX           26..31
FT                   /evidence="ECO:0000244|PDB:2VE3"
FT   HELIX           35..43
FT                   /evidence="ECO:0000244|PDB:2VE3"
FT   STRAND          45..51
FT                   /evidence="ECO:0000244|PDB:2VE3"
FT   STRAND          54..59
FT                   /evidence="ECO:0000244|PDB:2VE3"
FT   HELIX           62..68
FT                   /evidence="ECO:0000244|PDB:2VE3"
FT   TURN            73..75
FT                   /evidence="ECO:0000244|PDB:2VE3"
FT   STRAND          76..79
FT                   /evidence="ECO:0000244|PDB:2VE3"
FT   HELIX           82..88
FT                   /evidence="ECO:0000244|PDB:2VE3"
FT   HELIX           93..95
FT                   /evidence="ECO:0000244|PDB:2VE3"
FT   HELIX           98..109
FT                   /evidence="ECO:0000244|PDB:2VE3"
FT   HELIX           110..112
FT                   /evidence="ECO:0000244|PDB:2VE3"
FT   HELIX           114..118
FT                   /evidence="ECO:0000244|PDB:2VE3"
FT   HELIX           121..137
FT                   /evidence="ECO:0000244|PDB:2VE3"
FT   STRAND          138..142
FT                   /evidence="ECO:0000244|PDB:2VE3"
FT   HELIX           143..159
FT                   /evidence="ECO:0000244|PDB:2VE3"
FT   HELIX           162..165
FT                   /evidence="ECO:0000244|PDB:2VE3"
FT   HELIX           170..180
FT                   /evidence="ECO:0000244|PDB:2VE3"
FT   STRAND          181..183
FT                   /evidence="ECO:0000244|PDB:2VE3"
FT   HELIX           192..215
FT                   /evidence="ECO:0000244|PDB:2VE3"
FT   HELIX           224..230
FT                   /evidence="ECO:0000244|PDB:2VE3"
FT   HELIX           241..272
FT                   /evidence="ECO:0000244|PDB:2VE3"
FT   HELIX           274..285
FT                   /evidence="ECO:0000244|PDB:2VE3"
FT   HELIX           295..298
FT                   /evidence="ECO:0000244|PDB:2VE3"
FT   HELIX           302..314
FT                   /evidence="ECO:0000244|PDB:2VE3"
FT   STRAND          320..327
FT                   /evidence="ECO:0000244|PDB:2VE3"
FT   STRAND          329..331
FT                   /evidence="ECO:0000244|PDB:2VE3"
FT   STRAND          334..336
FT                   /evidence="ECO:0000244|PDB:2VE3"
FT   STRAND          341..345
FT                   /evidence="ECO:0000244|PDB:2VE3"
FT   HELIX           346..349
FT                   /evidence="ECO:0000244|PDB:2VE3"
FT   TURN            353..355
FT                   /evidence="ECO:0000244|PDB:2VE3"
FT   STRAND          356..358
FT                   /evidence="ECO:0000244|PDB:2VE3"
FT   HELIX           364..366
FT                   /evidence="ECO:0000244|PDB:2VE3"
FT   TURN            372..375
FT                   /evidence="ECO:0000244|PDB:2VE3"
FT   HELIX           387..389
FT                   /evidence="ECO:0000244|PDB:2VE3"
FT   HELIX           394..411
FT                   /evidence="ECO:0000244|PDB:2VE3"
FT   STRAND          412..416
FT                   /evidence="ECO:0000244|PDB:2VE3"
FT   STRAND          424..432
FT                   /evidence="ECO:0000244|PDB:2VE3"
FT   STRAND          437..442
FT                   /evidence="ECO:0000244|PDB:2VE3"
SQ   SEQUENCE   444 AA;  50578 MW;  8F62A9EED3B54BDC CRC64;
     MITSPTNLNS LPIPPGDFGL PWLGETLNFL NDGDFGKKRQ QQFGPIFKTR LFGKNVIFIS
     GALANRFLFT KEQETFQATW PLSTRILLGP NALATQMGEI HRSRRKILYQ AFLPRTLDSY
     LPKMDGIVQG YLEQWGKANE VIWYPQLRRM TFDVAATLFM GEKVSQNPQL FPWFETYIQG
     LFSLPIPLPN TLFGKSQRAR ALLLAELEKI IKARQQQPPS EEDALGILLA ARDDNNQPLS
     LPELKDQILL LLFAGHETLT SALSSFCLLL GQHSDIRERV RQEQNKLQLS QELTAETLKK
     MPYLDQVLQE VLRLIPPVGG GFRELIQDCQ FQGFHFPKGW LVSYQISQTH ADPDLYPDPE
     KFDPERFTPD GSATHNPPFA HVPFGGGLRE CLGKEFARLE MKLFATRLIQ QFDWTLLPGQ
     NLELVVTPSP RPKDNLRVKL HSLM
//
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