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Database: UniProt
Entry: Q59LU0
LinkDB: Q59LU0
Original site: Q59LU0 
ID   DBP2_CANAL              Reviewed;         562 AA.
AC   Q59LU0; A0A1D8PS76;
DT   04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 2.
DT   16-OCT-2019, entry version 87.
DE   RecName: Full=ATP-dependent RNA helicase DBP2;
DE            EC=3.6.4.13;
GN   Name=DBP2; OrderedLocusNames=CAALFM_CR02530WA;
GN   ORFNames=CaO19.171, CaO19.7804;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Debaryomycetaceae;
OC   Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S.,
RA   Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T.,
RA   Davis R.W., Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs
RT   aligned on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME
RP   REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates
RT   allele-specific measurements and provides a simple model for repeat
RT   and indel structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- FUNCTION: ATP-dependent RNA helicase involved nonsense-mediated
CC       mRNA decay and ribosome biogenesis through rRNA processing.
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC   -!- SUBUNIT: Associates with polysomes. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus
CC       {ECO:0000250}.
CC   -!- DOMAIN: The Q motif is unique to and characteristic of the DEAD
CC       box family of RNA helicases and controls ATP binding and
CC       hydrolysis.
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DDX5/DBP2
CC       subfamily. {ECO:0000305}.
DR   EMBL; CP017630; AOW30997.1; -; Genomic_DNA.
DR   RefSeq; XP_019331065.1; XM_019475520.1.
DR   SMR; Q59LU0; -.
DR   STRING; 5476.C4YL77; -.
DR   PRIDE; Q59LU0; -.
DR   GeneID; 3647692; -.
DR   KEGG; cal:CAALFM_CR02530WA; -.
DR   CGD; CAL0000194603; DBP2.
DR   EuPathDB; FungiDB:CR_02530W_A; -.
DR   InParanoid; Q59LU0; -.
DR   KO; K12823; -.
DR   OMA; DFKNLCM; -.
DR   OrthoDB; 638613at2759; -.
DR   PRO; PR:Q59LU0; -.
DR   Proteomes; UP000000559; Chromosome R.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:1990904; C:ribonucleoprotein complex; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:UniProtKB-KW.
DR   GO; GO:0006364; P:rRNA processing; IBA:GO_Central.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000629; RNA-helicase_DEAD-box_CS.
DR   InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00039; DEAD_ATP_HELICASE; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS51195; Q_MOTIF; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; Helicase; Hydrolase;
KW   Nonsense-mediated mRNA decay; Nucleotide-binding; Nucleus;
KW   Reference proteome; Ribosome biogenesis; RNA-binding; rRNA processing.
FT   CHAIN         1    562       ATP-dependent RNA helicase DBP2.
FT                                /FTId=PRO_0000232166.
FT   DOMAIN      158    333       Helicase ATP-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00541}.
FT   DOMAIN      358    508       Helicase C-terminal.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00542}.
FT   NP_BIND     171    178       ATP. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00541}.
FT   REGION      518    546       RNA-binding RGG-box. {ECO:0000250}.
FT   MOTIF       127    155       Q motif.
FT   MOTIF       281    284       DEAD box.
SQ   SEQUENCE   562 AA;  61281 MW;  8CD2F7CFBA08A392 CRC64;
     MSYNNGGYNN RNGGSYGGGY GGGGSRGGRD GYSGGGRGGG YGGGDRDQGG YRGGRFSGGG
     RGGGRFNDAP RQELTAPQWD LEQLPKFEKN FYSEHPDVAA RSDRDIEQFR KENEMTVKGH
     DIPHPITTFD EAGFPDYVLQ EVKDQGFPKP TPIQCQGWPM ALSGRDMIGI AATGSGKTLS
     YCLPSIVHIN AQPQLQYGDG PIVLVLAPTR ELAVQIQTEC SKFGKSSRIR NTCVYGGAPK
     GPQIRDLARG VEICIATPGR LIDMLEAGKT NLKRVTYLVL DEADRMLDMG FEPQIRKIVD
     QIRPDRQTLM WSATWPKEVQ QLTRDYLNDP IQVTIGSLEL AASHTITQLV EVIDEFSKRD
     RLVKHLESAL NEKDNKILVF ASTKRTCDEI TTYLRSDGWP ALAIHGDKEQ NERDWVLDEF
     RKGKTSIMVA TDVAARGIDV KGITHVINYD MPGNIEDYVH RIGRTGRGGA SGTAISFFTE
     GNSKLGGDLC KIMREANQTV PPELQRFDRR SYGSHMRFGQ GRGGRGGRGG RGGRGGRGGY
     GGGGGYRSTG GNSAPLGGNR RF
//
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