ID Q59P51_CANAL Unreviewed; 319 AA.
AC Q59P51;
DT 26-APR-2005, integrated into UniProtKB/TrEMBL.
DT 26-APR-2005, sequence version 1.
DT 28-JUN-2023, entry version 76.
DE RecName: Full=Checkpoint protein {ECO:0000256|PIRNR:PIRNR011312};
GN Name=MEC3 {ECO:0000313|CGD:CAL0000188998,
GN ECO:0000313|EMBL:AOW27630.1};
GN OrderedLocusNames=CAALFM_C206220CA {ECO:0000313|EMBL:AOW27630.1},
GN orf19.12940 {ECO:0000313|CGD:CAL0000188998};
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561 {ECO:0000313|EMBL:AOW27630.1, ECO:0000313|Proteomes:UP000000559};
RN [1] {ECO:0000313|EMBL:AOW27630.1, ECO:0000313|Proteomes:UP000000559}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876 {ECO:0000313|Proteomes:UP000000559};
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2] {ECO:0000313|EMBL:AOW27630.1, ECO:0000313|Proteomes:UP000000559}
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876 {ECO:0000313|Proteomes:UP000000559};
RX PubMed=17419877; DOI=.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3] {ECO:0000313|EMBL:AOW27630.1, ECO:0000313|Proteomes:UP000000559}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876 {ECO:0000313|Proteomes:UP000000559};
RX PubMed=24025428; DOI=.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC -!- SIMILARITY: Belongs to the HUS1 family. {ECO:0000256|ARBA:ARBA00005563,
CC ECO:0000256|PIRNR:PIRNR011312}.
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DR EMBL; CP017624; AOW27630.1; -; Genomic_DNA.
DR RefSeq; XP_711477.1; XM_706385.1.
DR AlphaFoldDB; Q59P51; -.
DR SMR; Q59P51; -.
DR STRING; 237561.Q59P51; -.
DR EnsemblFungi; C2_06220C_A-T; C2_06220C_A-T-p1; C2_06220C_A.
DR GeneID; 3646910; -.
DR KEGG; cal:CAALFM_C206220CA; -.
DR CGD; CAL0000188998; MEC3.
DR VEuPathDB; FungiDB:C2_06220C_A; -.
DR eggNOG; ENOG502RA7D; Eukaryota.
DR HOGENOM; CLU_074844_0_0_1; -.
DR InParanoid; Q59P51; -.
DR OrthoDB; 1985401at2759; -.
DR Proteomes; UP000000559; Chromosome 2.
DR GO; GO:0030896; C:checkpoint clamp complex; IBA:GO_Central.
DR GO; GO:0005730; C:nucleolus; IEA:InterPro.
DR GO; GO:0035861; C:site of double-strand break; IBA:GO_Central.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IBA:GO_Central.
DR GO; GO:0044778; P:meiotic DNA integrity checkpoint signaling; IBA:GO_Central.
DR GO; GO:0033314; P:mitotic DNA replication checkpoint signaling; IBA:GO_Central.
DR GO; GO:0031573; P:mitotic intra-S DNA damage checkpoint signaling; IBA:GO_Central.
DR GO; GO:0006289; P:nucleotide-excision repair; IBA:GO_Central.
DR GO; GO:0000723; P:telomere maintenance; IBA:GO_Central.
DR Gene3D; 3.70.10.10; -; 1.
DR InterPro; IPR016580; Cell_cycle_HUS1.
DR InterPro; IPR007150; Hus1/Mec3.
DR PANTHER; PTHR12900:SF0; CHECKPOINT PROTEIN; 1.
DR PANTHER; PTHR12900; MITOTIC AND DNA DAMAGE CHECKPOINT PROTEIN HUS1; 1.
DR Pfam; PF04005; Hus1; 1.
DR PIRSF; PIRSF011312; Cell_cycle_HUS1; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000000559}.
SQ SEQUENCE 319 AA; 36061 MW; 86DFAFB4FA9C81FD CRC64;
MKLKLMTKSS EKLKETLSLI SHVRKFVVLK FTPSELSVIS INGQAVKSEP QVWCKLPVSE
LFQSCEIQSV RDNTISMEIN IDLLVQTLKN FDKANSEGLN IRLQRTDTSG AKGTSTTTGR
TASLALFYSN LNINANVVNH TFRIPVKILR DAQDMLHEPT HSDLGLIMRL PNEFVTMFKR
LEKFKKVPSS ESVTIRASRR NGGFLGFILE ESGKFKVTIS WNDKLEVHKP TTTENDSLRE
TLRNGPSQLG ENEKDITSDI DEIEVNVKLK DWQSASKIVG RCRTVILYIG ERECSLHCLL
DDTDDVEIVY FITGSRITH
//
