ID Q59SS1_CANAL Unreviewed; 312 AA.
AC Q59SS1;
DT 26-APR-2005, integrated into UniProtKB/TrEMBL.
DT 26-APR-2005, sequence version 1.
DT 27-MAR-2024, entry version 88.
DE SubName: Full=Ccc1p {ECO:0000313|EMBL:AOW28398.1};
GN Name=CCC1 {ECO:0000313|CGD:CAL0000198298,
GN ECO:0000313|EMBL:AOW28398.1};
GN OrderedLocusNames=CAALFM_C303710WA {ECO:0000313|EMBL:AOW28398.1},
GN orf19.14210 {ECO:0000313|CGD:CAL0000198298};
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561 {ECO:0000313|EMBL:AOW28398.1, ECO:0000313|Proteomes:UP000000559};
RN [1] {ECO:0000313|EMBL:AOW28398.1, ECO:0000313|Proteomes:UP000000559}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876 {ECO:0000313|Proteomes:UP000000559};
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2] {ECO:0000313|EMBL:AOW28398.1, ECO:0000313|Proteomes:UP000000559}
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876 {ECO:0000313|Proteomes:UP000000559};
RX PubMed=17419877; DOI=.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3] {ECO:0000313|EMBL:AOW28398.1, ECO:0000313|Proteomes:UP000000559}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876 {ECO:0000313|Proteomes:UP000000559};
RX PubMed=24025428; DOI=.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CCC1 family.
CC {ECO:0000256|ARBA:ARBA00007049}.
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DR EMBL; CP017625; AOW28398.1; -; Genomic_DNA.
DR RefSeq; XP_712749.1; XM_707656.2.
DR AlphaFoldDB; Q59SS1; -.
DR SMR; Q59SS1; -.
DR STRING; 237561.Q59SS1; -.
DR EnsemblFungi; C3_03710W_A-T; C3_03710W_A-T-p1; C3_03710W_A.
DR GeneID; 3645645; -.
DR KEGG; cal:CAALFM_C303710WA; -.
DR CGD; CAL0000198298; CCC1.
DR VEuPathDB; FungiDB:C3_03710W_A; -.
DR eggNOG; KOG4473; Eukaryota.
DR HOGENOM; CLU_038957_0_0_1; -.
DR InParanoid; Q59SS1; -.
DR OMA; MNFHHTL; -.
DR OrthoDB; 1357at2759; -.
DR Proteomes; UP000000559; Chromosome 3.
DR GO; GO:0000329; C:fungal-type vacuole membrane; IBA:GO_Central.
DR GO; GO:0005794; C:Golgi apparatus; IEA:EnsemblFungi.
DR GO; GO:0005886; C:plasma membrane; IDA:CGD.
DR GO; GO:0015093; F:ferrous iron transmembrane transporter activity; IEA:EnsemblFungi.
DR GO; GO:0005381; F:iron ion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005384; F:manganese ion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0030447; P:filamentous growth; IMP:CGD.
DR GO; GO:0006874; P:intracellular calcium ion homeostasis; IEA:EnsemblFungi.
DR GO; GO:0030026; P:intracellular manganese ion homeostasis; IBA:GO_Central.
DR GO; GO:0006880; P:intracellular sequestering of iron ion; IBA:GO_Central.
DR GO; GO:0006693; P:prostaglandin metabolic process; IMP:CGD.
DR CDD; cd02435; CCC1; 1.
DR InterPro; IPR008217; Ccc1_fam.
DR PANTHER; PTHR31851; FE(2+)/MN(2+) TRANSPORTER PCL1; 1.
DR PANTHER; PTHR31851:SF52; PROTEIN CCC1; 1.
DR Pfam; PF01988; VIT1; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000559};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 226..246
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 252..271
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 291..311
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 312 AA; 33300 MW; 7E80FDEDFD7113D1 CRC64;
MSLVAIKNGI SKLVSSKDAS DAELERVERL IDSNQIPYGS TDSNDERAQQ LAREEAIIQA
AASISAASSS ENKEEEGVDS ITAFFNTFDP RVMSDIIIGL SDGLTVPFAL TAGLSSLGDS
KLVITGGMAE LVSGAISMGL GGYLAAKSES EYYFSQVKKE KLEFFKKPEA INQDAAEIMF
ELGASEQTII SFLKDLDAKP KNLIDFVIRY GKGLEEPAAG RELTSALTIG ASYFLGGFVP
LLPYFFTKEV GTGLIISVVA MLVVLMLFGY FKCSISMGEG CPNHKKFAAG FEMVVVGSIA
AGAAWGLVFL IE
//
