ID TRY3_CANAL Reviewed; 494 AA.
AC Q5A1M4; A0A1D8PN31;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2017, sequence version 2.
DT 27-MAR-2024, entry version 109.
DE RecName: Full=Transcriptional regulator of yeast form adherence 3;
GN Name=TRY3; OrderedLocusNames=CAALFM_C500980WA;
GN ORFNames=CaO19.1971, CaO19.9527;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN [4]
RP INDUCTION.
RX PubMed=22265407; DOI=10.1016/j.cell.2011.10.048;
RA Nobile C.J., Fox E.P., Nett J.E., Sorrells T.R., Mitrovich Q.M.,
RA Hernday A.D., Tuch B.B., Andes D.R., Johnson A.D.;
RT "A recently evolved transcriptional network controls biofilm development in
RT Candida albicans.";
RL Cell 148:126-138(2012).
RN [5]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=22359502; DOI=10.1371/journal.ppat.1002525;
RA Finkel J.S., Xu W., Huang D., Hill E.M., Desai J.V., Woolford C.A.,
RA Nett J.E., Taff H., Norice C.T., Andes D.R., Lanni F., Mitchell A.P.;
RT "Portrait of Candida albicans adherence regulators.";
RL PLoS Pathog. 8:E1002525-E1002525(2012).
CC -!- FUNCTION: Transcription factor required for yeast cell adherence to
CC silicone substrate. {ECO:0000269|PubMed:22359502}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- INDUCTION: Expression is induced in biofilm.
CC {ECO:0000269|PubMed:22265407}.
CC -!- DISRUPTION PHENOTYPE: Decreases cell adherence to silicone substrate.
CC {ECO:0000269|PubMed:22359502}.
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DR EMBL; CP017627; AOW29538.1; -; Genomic_DNA.
DR RefSeq; XP_715733.2; XM_710640.2.
DR AlphaFoldDB; Q5A1M4; -.
DR SMR; Q5A1M4; -.
DR STRING; 237561.Q5A1M4; -.
DR EnsemblFungi; C5_00980W_A-T; C5_00980W_A-T-p1; C5_00980W_A.
DR GeneID; 3642652; -.
DR KEGG; cal:CAALFM_C500980WA; -.
DR CGD; CAL0000186243; TRY3.
DR VEuPathDB; FungiDB:C5_00980W_A; -.
DR eggNOG; KOG4159; Eukaryota.
DR HOGENOM; CLU_017137_2_1_1; -.
DR InParanoid; Q5A1M4; -.
DR OrthoDB; 3904425at2759; -.
DR PRO; PR:Q5A1M4; -.
DR Proteomes; UP000000559; Chromosome 5.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:1900189; P:positive regulation of cell adhesion involved in single-species biofilm formation; IMP:CGD.
DR GO; GO:0010811; P:positive regulation of cell-substrate adhesion; IMP:CGD.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IMP:CGD.
DR GO; GO:0044011; P:single-species biofilm formation on inanimate substrate; IMP:CGD.
DR CDD; cd23137; RING-HC_TRY3-like; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR004331; SPX_dom.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR23327; RING FINGER PROTEIN 127; 1.
DR PANTHER; PTHR23327:SF50; TRANSCRIPTIONAL REGULATOR OF YEAST FORM ADHERENCE 3; 1.
DR Pfam; PF03105; SPX; 1.
DR Pfam; PF15227; zf-C3HC4_4; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS51382; SPX; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 2: Evidence at transcript level;
KW Cell adhesion; Metal-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..494
FT /note="Transcriptional regulator of yeast form adherence 3"
FT /id="PRO_0000426090"
FT DOMAIN 1..360
FT /note="SPX"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00714"
FT ZN_FING 398..437
FT /note="RING-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
SQ SEQUENCE 494 AA; 57301 MW; 4D4562193BBB6CDD CRC64;
MKFAKTLERT LEEDEIPQEW VEAAIQYKAL KKCINKVVNE LEFLGLQKNT LKILLNDKVV
EVNEQETNPS NPIIAEYILS KTSTDAHNIK PMLKITLDYS SEDYTKDHIV ELGKELKQKI
EALLNDSDTE YEEDKIIELK EDDGGDLQIV TSREGSLSPP ASRMASPPTS PTLKVVDSLN
TNIDEALLSP DDHHKKHEIF IMLNSDSKFF EMLNDELNSL DTLTQQEESK IIEEVKKIAK
YVNELKLKQS ELYKWRELFK VYLDSEVYFK YNETALPSQQ KSSEQIKSNL DLFVTNLNKS
GIMTRFKKKQ SLETFNQFME MNYHLLKILQ FQTINNEALR KILKKFDKQT SLGIQKTFPK
LISNDHIFMS GSSLAQSICY IIQESIIKVI PQLDDYSCPI CMNIAYKPIR LSCGHLFCVR
CLVKMKQDDK TSCPLCRKEN AILYADSSNL DLESMELMKK YFPREVKEKL RERDKERYNE
LRKNANSGEK CIVM
//
