ID Q5A501_CANAL Unreviewed; 235 AA.
AC Q5A501;
DT 26-APR-2005, integrated into UniProtKB/TrEMBL.
DT 26-APR-2005, sequence version 1.
DT 24-JAN-2024, entry version 108.
DE SubName: Full=ESCRT-III subunit protein {ECO:0000313|EMBL:AOW29488.1};
GN Name=VPS2 {ECO:0000313|CGD:CAL0000182454,
GN ECO:0000313|EMBL:AOW29488.1};
GN OrderedLocusNames=CAALFM_C500440CA {ECO:0000313|EMBL:AOW29488.1},
GN orf19.8560 {ECO:0000313|CGD:CAL0000182454};
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561 {ECO:0000313|EMBL:AOW29488.1, ECO:0000313|Proteomes:UP000000559};
RN [1] {ECO:0000313|EMBL:AOW29488.1, ECO:0000313|Proteomes:UP000000559}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876 {ECO:0000313|Proteomes:UP000000559};
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2] {ECO:0000313|EMBL:AOW29488.1, ECO:0000313|Proteomes:UP000000559}
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876 {ECO:0000313|Proteomes:UP000000559};
RX PubMed=17419877; DOI=.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3] {ECO:0000313|EMBL:AOW29488.1, ECO:0000313|Proteomes:UP000000559}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876 {ECO:0000313|Proteomes:UP000000559};
RX PubMed=24025428; DOI=.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC -!- SIMILARITY: Belongs to the SNF7 family.
CC {ECO:0000256|ARBA:ARBA00006190}.
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DR EMBL; CP017627; AOW29488.1; -; Genomic_DNA.
DR RefSeq; XP_716784.1; XM_711691.1.
DR AlphaFoldDB; Q5A501; -.
DR SMR; Q5A501; -.
DR STRING; 237561.Q5A501; -.
DR EnsemblFungi; C5_00440C_A-T; C5_00440C_A-T-p1; C5_00440C_A.
DR GeneID; 3641546; -.
DR KEGG; cal:CAALFM_C500440CA; -.
DR CGD; CAL0000182454; VPS2.
DR VEuPathDB; FungiDB:C5_00440C_A; -.
DR eggNOG; KOG3230; Eukaryota.
DR HOGENOM; CLU_069208_1_0_1; -.
DR InParanoid; Q5A501; -.
DR OMA; RYAKKFM; -.
DR OrthoDB; 198578at2759; -.
DR Proteomes; UP000000559; Chromosome 5.
DR GO; GO:0000815; C:ESCRT III complex; ISS:CGD.
DR GO; GO:0005771; C:multivesicular body; IBA:GO_Central.
DR GO; GO:1904669; P:ATP export; IEA:EnsemblFungi.
DR GO; GO:0032509; P:endosome transport via multivesicular body sorting pathway; IBA:GO_Central.
DR GO; GO:0070676; P:intralumenal vesicle formation; IEA:EnsemblFungi.
DR GO; GO:0045324; P:late endosome to vacuole transport; IBA:GO_Central.
DR GO; GO:0045053; P:protein retention in Golgi apparatus; IEA:EnsemblFungi.
DR GO; GO:0006623; P:protein targeting to vacuole; ISS:CGD.
DR GO; GO:0015031; P:protein transport; IBA:GO_Central.
DR GO; GO:0043328; P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; IEA:EnsemblFungi.
DR Gene3D; 6.10.140.1230; -; 1.
DR InterPro; IPR005024; Snf7_fam.
DR PANTHER; PTHR10476; CHARGED MULTIVESICULAR BODY PROTEIN; 1.
DR PANTHER; PTHR10476:SF4; CHARGED MULTIVESICULAR BODY PROTEIN 2A; 1.
DR Pfam; PF03357; Snf7; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000000559}.
FT REGION 211..235
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 16..50
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 218..235
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 235 AA; 26443 MW; 4BCBFE19C55CD81A CRC64;
MSQLFEWAFG KKLTPQERLR KNQRALEKTQ RELSREITKL QQQEKKLISD IKKSAKSGQI
SSAKIQAKDL IRTKSYVSKF TSMKTQLQAI SLRIQSVRSN QQMAMSMRDA TRVLGGMNRS
MNLPQLSRIA QEFAKESDMM DQKQEFMDDA IDDAMAMDED ELGEEEQVDE ILSKVLDEIG
VDLNTTLKDT PTGINAGNIE QADRARVAEA VGANGASSHD ADEDDLQARL DSLKK
//
