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Database: UniProt
Entry: Q5ACU6
LinkDB: Q5ACU6
Original site: Q5ACU6 
ID   RRP3_CANAL              Reviewed;         534 AA.
AC   Q5ACU6; A0A1D8PU15;
DT   04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   12-APR-2017, sequence version 3.
DT   16-OCT-2019, entry version 83.
DE   RecName: Full=ATP-dependent rRNA helicase RRP3 {ECO:0000305};
DE            EC=3.6.4.13 {ECO:0000250|UniProtKB:P38712};
GN   Name=RRP3 {ECO:0000250|UniProtKB:P38712};
GN   OrderedLocusNames=CAALFM_CR09740WA; ORFNames=CaO19.7546;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Debaryomycetaceae;
OC   Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Weinstock K.G., Bush D.;
RT   "Nucleic acid sequences relating to Candida albicans for diagnostics
RT   and therapeutics.";
RL   Patent number US6747137, 08-JUN-2004.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S.,
RA   Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T.,
RA   Davis R.W., Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs
RT   aligned on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME
RP   REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates
RT   allele-specific measurements and provides a simple model for repeat
RT   and indel structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- FUNCTION: ATP-dependent rRNA helicase required for pre-ribosomal
CC       RNA processing. Involved in the maturation of the 35S-pre-rRNA and
CC       to its cleavage to mature 18S rRNA.
CC       {ECO:0000250|UniProtKB:P38712}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC         Evidence={ECO:0000250|UniProtKB:P38712};
CC   -!- SUBUNIT: Interacts with the SSU processome.
CC       {ECO:0000250|UniProtKB:P38712}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- DOMAIN: The Q motif is unique to and characteristic of the DEAD
CC       box family of RNA helicases and controls ATP binding and
CC       hydrolysis. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DDX47/RRP3
CC       subfamily. {ECO:0000305}.
DR   EMBL; AR550432; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CP017630; AOW31631.1; -; Genomic_DNA.
DR   RefSeq; XP_719308.2; XM_714215.2.
DR   SMR; Q5ACU6; -.
DR   STRING; 5476.C4YN01; -.
DR   PRIDE; Q5ACU6; -.
DR   GeneID; 3639008; -.
DR   KEGG; cal:CAALFM_CR09740WA; -.
DR   CGD; CAL0000176052; orf19.7546.
DR   EuPathDB; FungiDB:CR_09740W_A; -.
DR   InParanoid; Q5ACU6; -.
DR   KO; K14777; -.
DR   OMA; KAKNRSI; -.
DR   OrthoDB; 744428at2759; -.
DR   Proteomes; UP000000559; Chromosome R.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006364; P:rRNA processing; IBA:GO_Central.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000629; RNA-helicase_DEAD-box_CS.
DR   InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00039; DEAD_ATP_HELICASE; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS51195; Q_MOTIF; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Helicase; Hydrolase;
KW   Nucleotide-binding; Nucleus; Reference proteome; Ribosome biogenesis;
KW   RNA-binding; rRNA processing.
FT   CHAIN         1    534       ATP-dependent rRNA helicase RRP3.
FT                                /FTId=PRO_0000232270.
FT   DOMAIN      149    320       Helicase ATP-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00541}.
FT   DOMAIN      347    492       Helicase C-terminal.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00542}.
FT   NP_BIND     162    169       ATP. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00541}.
FT   MOTIF       118    146       Q motif. {ECO:0000305}.
FT   MOTIF       268    271       DEAD box. {ECO:0000305}.
SQ   SEQUENCE   534 AA;  59792 MW;  AAE61037DB03EEB6 CRC64;
     MTMMNEKLKK EKKKIFGVIT PFQKYLYTPR IINTVHLIIM SSKGITKKKV KSLKNLDSTK
     KLAEKIKQQA LQKQQKQQKQ QEQENANHNQ TESSLSSSSS TTSSSITTID PDAELKFKTF
     KELNLVPDLL ESIESMKFTK PTPIQSEAIP HALEGKDIIG LAQTGSGKTA AFAIPILQSL
     WHAQQPYFAL VLAPTRELAF QIKDTFDALG SSMGLRSSCI VGGMDMMDQA RDLMRKPHVI
     VATPGRIMDH LEHTKGFSLK NLKYLVMDEA DRLLDMDFGP ALDKILKVIP IKRTTYLFSA
     TMTNKIEKLQ RASLHNPVRV AVSSKYQTAD NLVQSMMLVN DGYKNTILIH LLNEFMGKSI
     IVFTRTVAHA QRTALLARIL GFNAVPLHGQ LSQSQRLGSL NKFKSNQANI LVATDVAARG
     LDIPSVDVVI NYDIPTDSKA YIHRVGRTAR AGRSGKSISL ITQYDLEMYL RIESVLGKKL
     PKEDKPPKEV LDALHVHVDK ATAEAIRQTK EIHDKRNGGG GRRRNRDDAD REER
//
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