ID Q5AGW7_CANAL Unreviewed; 2252 AA.
AC Q5AGW7; Q3MPI5;
DT 26-APR-2005, integrated into UniProtKB/TrEMBL.
DT 26-APR-2005, sequence version 1.
DT 08-NOV-2023, entry version 140.
DE SubName: Full=Bem2p {ECO:0000313|EMBL:AOW30521.1};
GN Name=BEM2 {ECO:0000313|CGD:CAL0000181133,
GN ECO:0000313|EMBL:AOW30521.1};
GN OrderedLocusNames=CAALFM_C701550WA {ECO:0000313|EMBL:AOW30521.1},
GN orf19.13926 {ECO:0000313|CGD:CAL0000181133};
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561 {ECO:0000313|EMBL:AOW30521.1, ECO:0000313|Proteomes:UP000000559};
RN [1] {ECO:0000313|EMBL:AOW30521.1, ECO:0000313|Proteomes:UP000000559}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876 {ECO:0000313|Proteomes:UP000000559};
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2] {ECO:0000313|EMBL:AOW30521.1, ECO:0000313|Proteomes:UP000000559}
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876 {ECO:0000313|Proteomes:UP000000559};
RX PubMed=17419877; DOI=.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3] {ECO:0000313|EMBL:AOW30521.1, ECO:0000313|Proteomes:UP000000559}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876 {ECO:0000313|Proteomes:UP000000559};
RX PubMed=24025428; DOI=.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
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DR EMBL; CP017629; AOW30521.1; -; Genomic_DNA.
DR RefSeq; XP_721409.1; XM_716316.1.
DR AlphaFoldDB; Q5AGW7; -.
DR STRING; 237561.Q5AGW7; -.
DR EnsemblFungi; C7_01550W_A-T; C7_01550W_A-T-p1; C7_01550W_A.
DR GeneID; 3637044; -.
DR KEGG; cal:CAALFM_C701550WA; -.
DR CGD; CAL0000181133; BEM2.
DR VEuPathDB; FungiDB:C7_01550W_A; -.
DR eggNOG; KOG1450; Eukaryota.
DR HOGENOM; CLU_002085_0_0_1; -.
DR InParanoid; Q5AGW7; -.
DR OMA; TLEDDRW; -.
DR OrthoDB; 1359393at2759; -.
DR Proteomes; UP000000559; Chromosome 7.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00159; RhoGAP; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR037769; Abr/Bcr.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR23182; BREAKPOINT CLUSTER REGION PROTEIN BCR; 1.
DR PANTHER; PTHR23182:SF1; RHO GTPASE ACTIVATING PROTEIN AT 1A, ISOFORM E; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48366; Ras GEF; 2.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|PROSITE-ProRule:PRU00135};
KW Reference proteome {ECO:0000313|Proteomes:UP000000559}.
FT DOMAIN 1083..1272
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 1718..1830
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1851..2046
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 1..80
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 96..162
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 927..948
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1672..1708
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2053..2238
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 19..52
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2061..2083
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2084..2174
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2175..2205
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2210..2228
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2252 AA; 258822 MW; 2DB14DD571872A24 CRC64;
MRKIWNRKDK DKRKSVSHDT NSPNIYSNHH FDSNEHLPTQ SHQQGSDQYS DHNQNHNHNH
HRNHQHQHHH LVHTESHEDT TSFDYEDMAS IHEQPYSLSD KQSTTNTSTL SSTTAASTLA
TSNNTQPHTY TSTSTSIRGV GATGNSGSGG GGGTTKKLNS PQFQSSVAPN VKLNSLIKHD
HDTTVGKHSW VNGVFNGTEI NENNLKLYRA ELKGSHLYLY KAPTNLNVKK FRLQEPPIPK
EVEAMMKNNN DSSSSIHNFN NSSTSLANSN SINENVVSDP PQHNNDNATI ETNASTLIDT
KPLDVSQISS PIVQNTPTAH PPPLGMRKNS TIETTTIPVN RNVFHTPYSS SIPNTPVTAP
PTLPITSSID ISEHNITYYK VEVPHPDLLY DFDTHRFSAP FFKDGKNSLE AIFHFLLFNQ
DPLDTRTINT IVDVLPILPD FGKIMKFFSL YVHTIFEKKF EGMTNLELVV SRVLQVLQNL
EEHFDGFLLK SDIAPYILKV LEMINHYNIE DITIFKNKML QKQQVLIDLL NNDNLPLNVQ
PFQDLNSTVF MKEINLIDFA YTISEIDLKF FSNWNSNIDK SLLLYSSISD DTNRDFFYKK
NPLIFNNDYH IHYLSRLLVN HLFVENSSMN MSSANLENKA RLLEKWIDLG CLLDKSGNMS
SWLGISSVIL SQPVLRLTKI WSLVAPDYIR LLKSDWSPVL FELDRRYLVN ESTIDHGKST
HLGGNEESRD LSTKDSYHIM APRGLGKIYP KERVIPFFGD LVINNSGNTT DKSVDIYELE
SIWKRVNYSF DRWNDYLTNL TNYDEIIKYN DDVLRRYDSM GFIFSNESLN QVLFLGANNS
DERQLENPPS PIKRREVNND IKNKLLRLIE LNCDSINMEK IMKLSINLEP ELPEAYLDAT
TSISVAPSTS QESTLLKSNI NRSNLSVNSI DSSGSSNETP LSESNPASRI PSFNNKFFKI
DLGKYDELMK SGDKKDSPPL DPSVNKHNFV IDNELTFRID DFISELDNSS TSSVTGGGAV
GAGGGYDDFA GGDDDDDVPG LGIDVDDILN SDKFTNFSMS PKANNSKSNK RKLSMDGSMK
KIYKFIPKYA TVDRLIDLLL LDSKYFHRDV HLDLTEYRFV FLLNYNSFMT TKELLDKLAH
RFINSGNAVI SVMKKNYLLK KLNHESDKTK MEPNFNQGNP QLAMNFPNWN LDTAVDLNEL
GDVDYELLLK IQINILKVLI VLINNFYSNF SLDLANKNIL IKLLKLFSNE ILQWYNSNKI
DNTLEKSFES LVTYYKKLKK LFVKKTYRPV EVSKFDEYLI SEFRFNNSLH EVPMNRNLPS
HRNVHKIEKF LYKFNKLLAV FYKGIKTEDW VRVYKILENS FEKNALLDFS LQKPTVSDDQ
LIISNIFNFF ESLVIPDERQ LLLKKFPLVF RKLFKVYFKF KSYLLVQLTD LNITTDERLD
RMKTLLIMAE VSKLKMSDNQ FIFEGSGNIP SCIETAIINV IYSPESRKFS NLWVRAAQTL
THREGNFDSV ESLLPPNITI NDLQSTEPLL PCFGWIIENL IETDKCPSYF KNQINFNKRY
LIYKLIRELS VEDFEGESGS NDFTFNESRE FDFLLKLDES LVNQQNLREF SPVDKAEIFQ
RIMKDQHQIL VVDNQKKHIR DSKRLIKGTN NLSIRSATNS SFSNVHSGIS ASTSNTTTAA
GNTNNNNNNN NNNFNNNNNN NALSGMHNLT RKTSNTSLKR QSLSYKSSSS SRFKISGLFT
KSRPFSLTGN TSTPERVVNI EELPNPEDSI EPKQKPVVVI PLKNRKIFPV YLMPLCFKID
SETTNDHYFF QATNDTDLNE WLIKLNYANR HWFYSRILNN KTTNNNLVFG VPISFICVRE
LSVVPKFLEA IFQEIESEGI KDVGIYRISS SISELTSIKQ TIDRTGTINF NDRGYDTHAL
TSIVKSYFRE LPDSLITDDA ISQFYELKLE QENKNQTPDR DAFDLNAYQK ILHSLPVVNF
NTLKILVKHL NKISEHKEVN KMTPSNIATV IGPALTESSN LDILINNFGF MNLVLEKLIN
NYHEVFDDRE DEKKDIESDL NHAQGQNSET EIESQQQEQQ QNHQYEQEPE HEHHIQIQVK
PECEPQREPQ REQEREHERQ HERQHERQHE RQHERQHELE REQENKHEQK QKQEYDFGIK
HQHEHVDVKV DSKLGERQYQ QQQQSGLGQD NNNTPRKNNV IQSGVDPNDD GVHHLTKVVS
DDTTRTDKTV TKPNQNFIGQ GFGKEEELKV QF
//
