ID Q5AGX1_CANAL Unreviewed; 1128 AA.
AC Q5AGX1; Q3MPI2;
DT 26-APR-2005, integrated into UniProtKB/TrEMBL.
DT 26-APR-2005, sequence version 1.
DT 27-MAR-2024, entry version 118.
DE SubName: Full=DNA repair protein {ECO:0000313|EMBL:AOW30524.1};
GN Name=SMC6 {ECO:0000313|CGD:CAL0000185544,
GN ECO:0000313|EMBL:AOW30524.1};
GN OrderedLocusNames=CAALFM_C701580WA {ECO:0000313|EMBL:AOW30524.1},
GN orf19.13921 {ECO:0000313|CGD:CAL0000185544};
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561 {ECO:0000313|EMBL:AOW30524.1, ECO:0000313|Proteomes:UP000000559};
RN [1] {ECO:0000313|EMBL:AOW30524.1, ECO:0000313|Proteomes:UP000000559}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876 {ECO:0000313|Proteomes:UP000000559};
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2] {ECO:0000313|EMBL:AOW30524.1, ECO:0000313|Proteomes:UP000000559}
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876 {ECO:0000313|Proteomes:UP000000559};
RX PubMed=17419877; DOI=.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3] {ECO:0000313|EMBL:AOW30524.1, ECO:0000313|Proteomes:UP000000559}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876 {ECO:0000313|Proteomes:UP000000559};
RX PubMed=24025428; DOI=.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the SMC family. SMC6 subfamily.
CC {ECO:0000256|ARBA:ARBA00006793}.
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DR EMBL; CP017629; AOW30524.1; -; Genomic_DNA.
DR RefSeq; XP_721404.1; XM_716311.1.
DR AlphaFoldDB; Q5AGX1; -.
DR SMR; Q5AGX1; -.
DR STRING; 237561.Q5AGX1; -.
DR EnsemblFungi; C7_01580W_A-T; C7_01580W_A-T-p1; C7_01580W_A.
DR GeneID; 3637039; -.
DR KEGG; cal:CAALFM_C701580WA; -.
DR CGD; CAL0000185544; SMC6.
DR VEuPathDB; FungiDB:C7_01580W_A; -.
DR eggNOG; KOG0250; Eukaryota.
DR HOGENOM; CLU_009063_0_0_1; -.
DR InParanoid; Q5AGX1; -.
DR OMA; MCHDHFY; -.
DR OrthoDB; 78166at2759; -.
DR Proteomes; UP000000559; Chromosome 7.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0035861; C:site of double-strand break; IBA:GO_Central.
DR GO; GO:0030915; C:Smc5-Smc6 complex; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IBA:GO_Central.
DR GO; GO:0003697; F:single-stranded DNA binding; IBA:GO_Central.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IBA:GO_Central.
DR Gene3D; 1.10.287.1490; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038729; Rad50/SbcC_AAA.
DR PANTHER; PTHR19306; STRUCTURAL MAINTENANCE OF CHROMOSOMES 5,6 SMC5, SMC6; 1.
DR PANTHER; PTHR19306:SF6; STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 6; 1.
DR Pfam; PF13476; AAA_23; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000000559}.
FT DOMAIN 108..375
FT /note="Rad50/SbcC-type AAA"
FT /evidence="ECO:0000259|Pfam:PF13476"
FT REGION 1..102
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 314..526
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 713..893
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 943..977
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..16
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 28..65
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 66..97
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1128 AA; 129807 MW; 4C06E15B1E056691 CRC64;
MTVPYKRKHD ADSLFDARNG GEGVSEYMSQ LLINSSDQPR KRRTMTQAPS RNGRESASET
ESISGADSDS DGESDDDEDD EDDDDDDEEE DDDDDVGSDP AKAGVIEKLT LKNFMCHDSF
ELKLGPQLNF IIGRNGSGKS AILTGISVGL GAKATDTNRG STIRDLIKDG KSTSRITVVL
KNEGSDAYKP DVFGKKIIIE RKLQRSGSNT YSIKNEAGKV VSNKKSVLDE ILYKFSITID
NPLAFLSQDK AREFLTSSSD KNKYEYFMDG AFITDILENY TSISNNVQVL DNKVRQAEEY
TKVAKQEYKA IAKVHNAHRT NDALRNKLEM LNAKIYWFNV QTIEKKIDQE NRQKDTCLQE
IEQAKNQIDV CEKEIEAKIP RKDAADQQVK EVESQIKDIV EEFEGLRSKR SEMKSELEIN
KKETKKNIDE MNSLKEDITR TETKIEQERR RIQELQGGNK EKMAEELEKL NSEIDELESQ
LENLKKQLVE MQDNPDPELR SVSQQREKSR QKIADLQNQK RQLEKESVSK YSPWGSRMAE
LIKAIKRHPD WVQEPIGPIG SYIHVKNQYN NWKPLLSTIL NKTLDSFIVT NEGDRSRLDR
LLKQYQIRSN IIVKKTERLN YASGKADSAF TTVLDMLNVE NDTILYALID INSIEKNVIV
ESASEARDSC RRRNVQNSLV LFRKDSGHRM SYQNNTFRQD PIYYQNGMAK FGVANMSDLI
SDLQRELDEE HRHQNDLERR ARSIKMKLDA KRDNLVSESR AIKRNLDQLK RNRSTLEDQL
EVEVDYSNIT TLEARIEDNN EQIRRLVALN EALLENLSQM NENYKDLKQQ IEDCKSKKVK
HETIREKFVK QLVEIETEIE TQEDLKKRYL YKITELEDRI KRADDILAEG NRKLEEFVAK
AEEHCSRDRV TIYPNDTQET IAQDYQETRF DLERAESALG TSLEEVLDQL EKAKAKCDKA
EGELESLSSA SRKLNAEVNA RFNFLHTIIQ SSIQEAKRTF EKAMWLRGFQ GTLKFDFAEK
TLQLNVQTGN DEKKRTVESL SGGEKSFSQI ALLLSIWKVM NSRIRGLDEF DVYMDSVNRS
ISIKLLLKEL KRYPKSQNIF ITPQDIAVVG ELNDKGVKIH KMSAPREE
//
