GenomeNet

Database: UniProt
Entry: Q5AK59
LinkDB: Q5AK59
Original site: Q5AK59 
ID   HAS1_CANAL              Reviewed;         565 AA.
AC   Q5AK59; A0A1D8PP16; Q5AKM2;
DT   04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   16-OCT-2019, entry version 79.
DE   RecName: Full=ATP-dependent RNA helicase HAS1;
DE            EC=3.6.4.13;
GN   Name=HAS1; OrderedLocusNames=CAALFM_C504750CA;
GN   ORFNames=CaO19.11444, CaO19.3962;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Debaryomycetaceae;
OC   Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S.,
RA   Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T.,
RA   Davis R.W., Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs
RT   aligned on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME
RP   REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates
RT   allele-specific measurements and provides a simple model for repeat
RT   and indel structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- FUNCTION: ATP-dependent RNA helicase involved in 40S ribosomal
CC       subunit biogenesis. Required for the processing and cleavage of
CC       35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC   -!- SUBUNIT: Associates in the nucleolus with the 60S and pre-60S
CC       ribosomal subunits. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- DOMAIN: The Q motif is unique to and characteristic of the DEAD
CC       box family of RNA helicases and controls ATP binding and
CC       hydrolysis.
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DDX18/HAS1
CC       subfamily. {ECO:0000305}.
DR   EMBL; CP017627; AOW29881.1; -; Genomic_DNA.
DR   RefSeq; XP_721871.1; XM_716778.2.
DR   SMR; Q5AK59; -.
DR   STRING; 5476.C4YRY4; -.
DR   PRIDE; Q5AK59; -.
DR   GeneID; 3636443; -.
DR   KEGG; cal:CAALFM_C504750CA; -.
DR   CGD; CAL0000175982; HAS1.
DR   EuPathDB; FungiDB:C5_04750C_A; -.
DR   InParanoid; Q5AK59; -.
DR   KO; K13179; -.
DR   OrthoDB; 973872at2759; -.
DR   PRO; PR:Q5AK59; -.
DR   Proteomes; UP000000559; Chromosome 5.
DR   GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR   GO; GO:0042274; P:ribosomal small subunit biogenesis; IGI:CGD.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR025313; DUF4217.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000629; RNA-helicase_DEAD-box_CS.
DR   InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF13959; DUF4217; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM01178; DUF4217; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   PROSITE; PS00039; DEAD_ATP_HELICASE; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS51195; Q_MOTIF; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Coiled coil; Complete proteome; Helicase; Hydrolase;
KW   Nucleotide-binding; Nucleus; Reference proteome; Ribosome biogenesis;
KW   RNA-binding; rRNA processing.
FT   CHAIN         1    565       ATP-dependent RNA helicase HAS1.
FT                                /FTId=PRO_0000232207.
FT   DOMAIN      139    314       Helicase ATP-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00541}.
FT   DOMAIN      328    498       Helicase C-terminal.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00542}.
FT   NP_BIND     152    159       ATP. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00541}.
FT   COILED       26     85       {ECO:0000255}.
FT   MOTIF       108    136       Q motif.
FT   MOTIF       261    264       DEAD box.
FT   MOTIF       340    356       Bipartite nuclear localization signal.
FT                                {ECO:0000250}.
SQ   SEQUENCE   565 AA;  63055 MW;  7ED2F3E6ED0FFF25 CRC64;
     MAKTTKVKGN KKKSDTSKVV SKVSRKRSHE DSESEVEDNE KVVEELDADF DEVAGLLGDD
     IEDPESKSQS KKEKQKAKDE AKLEQLTKPQ VSNEVPDNDN DDDSSEDVLF ENADFSEPTM
     KAIKEMGFTK MTKVQAKTIP PLLAGRDVLG AAKTGSGKTL AFLIPAIELL YSLKIKPRNG
     TAVIIITPTR ELALQIFGVA RELMQFHSQT CGIVIGGADR RQEATKLAKG VNLLVATPGR
     LLDHLKNTQF VFSNLKALVI DEADRILEIG FEDEMKQIIK VLPNENRQSM LFSATQTTKV
     EDLARISLRP GPLYINVVPE KDVSTADGLE QGYVVCDSDK RFLLLFSFLK RNVKKKIIVF
     LSSCNSVKFY SELLNYIDLP VLDLHGKQKQ QKRTNTFFEF CNAKQGILVC TDVAARGLDI
     PAVDWIVQFD PPDDPRDYIH RVGRTARGTQ GKGKSLMFLT PSELGFLRYL KAAKVPLNEY
     EFPANKIANI QSQLTKLIKT NYLLNQSAKD GYRAYLQAYA SHGLKTVYQI DKLDLKKVSA
     SFGLDQVPRV NLSIGGTKTK KQKRS
//
DBGET integrated database retrieval system