ID DAW1_RAT Reviewed; 415 AA.
AC Q5BK30;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 12-APR-2005, sequence version 1.
DT 27-MAR-2024, entry version 119.
DE RecName: Full=Dynein assembly factor with WD repeat domains 1;
DE AltName: Full=Outer row dynein assembly protein 16 homolog;
DE AltName: Full=WD repeat-containing protein 69;
GN Name=Daw1; Synonyms=Wdr69;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Required for axonemal dynein assembly and ciliary motility in
CC ciliated organs, including Kupffer's vesicle, during embryogenesis.
CC Facilitates the onset of robust cilia motility during development.
CC {ECO:0000250|UniProtKB:Q8N136}.
CC -!- SUBUNIT: Interacts with IFT46. {ECO:0000250|UniProtKB:Q8N136}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, flagellum basal body
CC {ECO:0000250|UniProtKB:Q3Y8L7}. Cytoplasm, cytoskeleton, flagellum
CC axoneme {ECO:0000250|UniProtKB:Q3Y8L7}. Note=Expression is concentrated
CC at the flagellum basal body but is also detected along the length of
CC the flagellum. {ECO:0000250|UniProtKB:Q3Y8L7}.
CC -!- SIMILARITY: Belongs to the WD repeat WDR69 family. {ECO:0000305}.
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DR EMBL; BC091226; AAH91226.1; -; mRNA.
DR RefSeq; NP_001020196.1; NM_001025025.1.
DR AlphaFoldDB; Q5BK30; -.
DR SMR; Q5BK30; -.
DR BioGRID; 264090; 1.
DR STRING; 10116.ENSRNOP00000059421; -.
DR PhosphoSitePlus; Q5BK30; -.
DR PaxDb; 10116-ENSRNOP00000059421; -.
DR GeneID; 363267; -.
DR KEGG; rno:363267; -.
DR UCSC; RGD:1561436; rat.
DR AGR; RGD:1561436; -.
DR CTD; 164781; -.
DR RGD; 1561436; Daw1.
DR VEuPathDB; HostDB:ENSRNOG00000016247; -.
DR eggNOG; KOG0272; Eukaryota.
DR HOGENOM; CLU_000288_57_33_1; -.
DR InParanoid; Q5BK30; -.
DR OrthoDB; 989707at2759; -.
DR PhylomeDB; Q5BK30; -.
DR TreeFam; TF323481; -.
DR PRO; PR:Q5BK30; -.
DR Proteomes; UP000002494; Chromosome 9.
DR Bgee; ENSRNOG00000016247; Expressed in testis and 6 other cell types or tissues.
DR ExpressionAtlas; Q5BK30; baseline.
DR GO; GO:0036064; C:ciliary basal body; ISS:UniProtKB.
DR GO; GO:0005929; C:cilium; ISS:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005576; C:extracellular region; IEA:GOC.
DR GO; GO:0031514; C:motile cilium; IEA:UniProtKB-KW.
DR GO; GO:0019005; C:SCF ubiquitin ligase complex; IBA:GO_Central.
DR GO; GO:1990756; F:ubiquitin ligase-substrate adaptor activity; IBA:GO_Central.
DR GO; GO:0090660; P:cerebrospinal fluid circulation; ISO:RGD.
DR GO; GO:0007368; P:determination of left/right symmetry; ISO:RGD.
DR GO; GO:0003351; P:epithelial cilium movement involved in extracellular fluid movement; ISO:RGD.
DR GO; GO:0051649; P:establishment of localization in cell; ISO:RGD.
DR GO; GO:0007507; P:heart development; ISO:RGD.
DR GO; GO:0042073; P:intraciliary transport; ISS:UniProtKB.
DR GO; GO:0036158; P:outer dynein arm assembly; ISS:UniProtKB.
DR GO; GO:0000209; P:protein polyubiquitination; IBA:GO_Central.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 4.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR22847:SF637; WD REPEAT DOMAIN 5; 1.
DR PANTHER; PTHR22847; WD40 REPEAT PROTEIN; 1.
DR Pfam; PF00400; WD40; 8.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 8.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 4.
DR PROSITE; PS50082; WD_REPEATS_2; 8.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 2: Evidence at transcript level;
KW Cell projection; Cilium; Cytoplasm; Cytoskeleton; Flagellum;
KW Reference proteome; Repeat; WD repeat.
FT CHAIN 1..415
FT /note="Dynein assembly factor with WD repeat domains 1"
FT /id="PRO_0000242656"
FT REPEAT 90..129
FT /note="WD 1"
FT REPEAT 132..174
FT /note="WD 2"
FT REPEAT 175..214
FT /note="WD 3"
FT REPEAT 217..256
FT /note="WD 4"
FT REPEAT 259..298
FT /note="WD 5"
FT REPEAT 301..340
FT /note="WD 6"
FT REPEAT 343..384
FT /note="WD 7"
FT REPEAT 386..415
FT /note="WD 8"
SQ SEQUENCE 415 AA; 45859 MW; 0F96FF1CD75275B5 CRC64;
MKLKSLLLRY YPPGIMLEYE KGGELKTKSI DLLELSPSTD VNTLVGEIQK VEPLITASRT
KQVRLLVQRL QEKLRQHCDH NFYLFKVLRA HILPLTNVAL NKAGSCFITG SYDRTCKVWD
TASGEELHTL EGHRNVVYAI AFNNPYGDKI ATGSFDKTCK LWSAETGKCY HTFRGHTAEI
VCLSFNPQST VVATGSMDTT AKLWDIQSGE EVVTLTGHLA EIISLSFDTS GDRIITGSFD
HTVVVWDAST GRKVHTLIGH CAEISSALFS WDCSLILTGS MDKTCMLWDA TSGKCVATLT
GHDDEILDSC FDYTGKLIAT ASADGTARVY NATTRKCITK LEGHEGEISK ISFNPQGNRL
LTGSSDKTAR IWDVQTGQCL QVLEGHTDEI FSCAFNYKGN IVITGSKDNS CRIWR
//