ID Q5BL42_XENTR Unreviewed; 723 AA.
AC Q5BL42; A0A6I8SUV3;
DT 12-APR-2005, integrated into UniProtKB/TrEMBL.
DT 12-APR-2005, sequence version 1.
DT 27-MAR-2024, entry version 147.
DE SubName: Full=Heat shock protein 90kDa alpha (Cytosolic), class B member 1 {ECO:0000313|EMBL:AAH90610.1};
DE SubName: Full=Heat shock protein 90kDa alpha family class B member 1 {ECO:0000313|Ensembl:ENSXETP00000098595};
DE SubName: Full=Heat shock protein HSP 90-beta {ECO:0000313|RefSeq:NP_001025655.1};
GN Name=hsp90ab1 {ECO:0000313|EMBL:AAH90610.1,
GN ECO:0000313|Ensembl:ENSXETP00000098595,
GN ECO:0000313|RefSeq:NP_001025655.1,
GN ECO:0000313|Xenbase:XB-GENE-495311};
GN Synonyms=d6s182 {ECO:0000313|RefSeq:NP_001025655.1}, hsp90-beta
GN {ECO:0000313|RefSeq:NP_001025655.1}, hsp90b
GN {ECO:0000313|RefSeq:NP_001025655.1}, hsp90beta
GN {ECO:0000313|RefSeq:NP_001025655.1}, hspc2
GN {ECO:0000313|RefSeq:NP_001025655.1}, hspcb
GN {ECO:0000313|RefSeq:NP_001025655.1};
GN ORFNames=XENTR_v90030784mg {ECO:0000313|EMBL:OCA15005.1};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|EMBL:AAH90610.1};
RN [1] {ECO:0000313|RefSeq:NP_001025655.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12454917; DOI=10.1002/dvdy.10174;
RA Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA Richardson P.;
RT "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT initiative.";
RL Dev. Dyn. 225:384-391(2002).
RN [2] {ECO:0000313|EMBL:AAH90610.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo {ECO:0000313|EMBL:AAH90610.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:OCA15005.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Nigerian {ECO:0000313|EMBL:OCA15005.1};
RG US DOE Joint Genome Institute (JGI-PGF);
RA Ottilar R., Schmutz J., Salamov A., Cheng J.F., Lucas S., Pitluck S.,
RA Gundlach H., Guo Y., Haberer G., Nasrallah J., Mayer K.F.X.,
RA van de Peer Y., Weigel D., Grigoriev I.V.;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:OCA15005.1, ECO:0000313|Ensembl:ENSXETP00000098595}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|EMBL:OCA15005.1,
RC ECO:0000313|Ensembl:ENSXETP00000098595};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [5] {ECO:0000313|EMBL:OCA15005.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Nigerian {ECO:0000313|EMBL:OCA15005.1};
RA Sessions A., Jenkins J., Mitros T., Lyons J.T., Dichmann D.S., Robert J.,
RA Harland R.M., Rokhsar D.S.;
RT "WGS assembly of Xenopus tropicalis.";
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
RN [6] {ECO:0000313|Ensembl:ENSXETP00000098595}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAY-2020) to UniProtKB.
RN [7] {ECO:0000313|RefSeq:NP_001025655.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Dynein axonemal particle
CC {ECO:0000256|ARBA:ARBA00024190}.
CC -!- SIMILARITY: Belongs to the heat shock protein 90 family.
CC {ECO:0000256|ARBA:ARBA00008239}.
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DR EMBL; BC090610; AAH90610.1; -; mRNA.
DR EMBL; KV461016; OCA15005.1; -; Genomic_DNA.
DR EMBL; KV461016; OCA15006.1; -; Genomic_DNA.
DR RefSeq; NP_001025655.1; NM_001030484.1.
DR DNASU; 595047; -.
DR Ensembl; ENSXETT00000096270; ENSXETP00000098595; ENSXETG00000010896.
DR GeneID; 595047; -.
DR KEGG; xtr:595047; -.
DR AGR; Xenbase:XB-GENE-495311; -.
DR CTD; 3326; -.
DR Xenbase; XB-GENE-495311; hsp90ab1.
DR eggNOG; KOG0019; Eukaryota.
DR OMA; TRMKAEQ; -.
DR OrthoDB; 547579at2759; -.
DR TreeFam; TF300686; -.
DR Reactome; R-XTR-168928; DDX58/IFIH1-mediated induction of interferon-alpha/beta.
DR Reactome; R-XTR-2029482; Regulation of actin dynamics for phagocytic cup formation.
DR Reactome; R-XTR-3371497; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand.
DR Reactome; R-XTR-3371511; HSF1 activation.
DR Reactome; R-XTR-3371571; HSF1-dependent transactivation.
DR Reactome; R-XTR-399954; Sema3A PAK dependent Axon repulsion.
DR Reactome; R-XTR-6798695; Neutrophil degranulation.
DR Reactome; R-XTR-844456; The NLRP3 inflammasome.
DR Reactome; R-XTR-8852276; The role of GTSE1 in G2/M progression after G2 checkpoint.
DR Reactome; R-XTR-8937144; Aryl hydrocarbon receptor signalling.
DR Reactome; R-XTR-9013418; RHOBTB2 GTPase cycle.
DR Proteomes; UP000008143; Chromosome 5.
DR Bgee; ENSXETG00000010896; Expressed in central nervous system and 29 other cell types or tissues.
DR GO; GO:0120293; C:dynein axonemal particle; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR GO; GO:0001568; P:blood vessel development; IEA:Ensembl.
DR GO; GO:0050900; P:leukocyte migration; IEA:Ensembl.
DR CDD; cd16927; HATPase_Hsp90-like; 1.
DR Gene3D; 3.30.230.80; -; 1.
DR Gene3D; 3.40.50.11260; -; 1.
DR Gene3D; 1.20.120.790; Heat shock protein 90, C-terminal domain; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR HAMAP; MF_00505; HSP90; 1.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR019805; Heat_shock_protein_90_CS.
DR InterPro; IPR037196; HSP90_C.
DR InterPro; IPR001404; Hsp90_fam.
DR InterPro; IPR020575; Hsp90_N.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR PANTHER; PTHR11528; HEAT SHOCK PROTEIN 90 FAMILY MEMBER; 1.
DR PANTHER; PTHR11528:SF79; HEAT SHOCK PROTEIN HSP 90-BETA-RELATED; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF00183; HSP90; 1.
DR PIRSF; PIRSF002583; Hsp90; 1.
DR PRINTS; PR00775; HEATSHOCK90.
DR SMART; SM00387; HATPase_c; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF110942; HSP90 C-terminal domain; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00298; HSP90; 1.
PE 2: Evidence at transcript level;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Chaperone {ECO:0000256|ARBA:ARBA00023186};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000008143};
KW Stress response {ECO:0000313|EMBL:AAH90610.1,
KW ECO:0000313|RefSeq:NP_001025655.1}.
FT DOMAIN 35..189
FT /note="Histidine kinase/HSP90-like ATPase"
FT /evidence="ECO:0000259|SMART:SM00387"
FT REGION 221..269
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 693..723
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 225..239
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 240..269
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 723 AA; 83211 MW; 8F6ACEE99D600C37 CRC64;
MPEVAHNGEE EVETFAFQAE IAQLMSLIIN TFYSNKEIFL RELISNASDA LDKIRYESLT
DPSKLDSGKD LKIDIIPNRQ ERTLTVIDTG IGMTKADLIN NLGTIAKSGT KAFMEALQAG
ADISMIGQFG VGFYSAYLVA EKVLVITKHN DDEQYAWESS AGGSFTVKTD HGEPIGRGTK
VILYLKEDQT EYLEEKRVKE TVKKHSQFIG YPITLYLEKE REKEISDDEA EEEKEEEKKE
EEGENDKPKI EDVGSDEEEE GKDKKKKTKK IKEKYIDQEE LNKTKPIWTR NPDDITQEEY
GEFYKSLTND WEDHLAVKHF SVEGQLEFRA LLFIPRRAPF DLFENKKKKN NIKLYVRRVF
IMDSCDELIP EYLNFIRGVV DSEDLPLNIS REMLQQSKIL KVIRKNIVKK CLELFTELAE
DKENYKKFYE AFSKNLKLGI HEDSTNRKKL SELLRYHTSQ TGDEMASLTE YVSRMKENQK
SIYYITGESK DQVANSAFVE RVRKRGFEVV YMTEPIDEYC VQQLKEFDGK TLVSVTKEGL
ELPEDEEEKK MMEENKTKFE SLCKLMKEIL DKKVEKVTVS NRLVSSPCCI VTSTYGWTAN
MERIMKAQAL RDNSTMGYMM AKKHLEINPE HPIVETLRQK AETDKNDKAV KDLVVLLFET
ALLSSGFSLD DPQTHSNRIY RMIKLGLGID DDDATVEETS PSVADEIPPL EGDEDASRME
EVD
//
