ID Q5BMN3_SALSA Unreviewed; 246 AA.
AC Q5BMN3;
DT 12-APR-2005, integrated into UniProtKB/TrEMBL.
DT 12-APR-2005, sequence version 1.
DT 27-MAR-2024, entry version 84.
DE SubName: Full=Tumor necrosis factor alpha-1 {ECO:0000313|EMBL:AAX24116.1, ECO:0000313|RefSeq:NP_001117061.1};
GN Name=TNF-alpha-1 {ECO:0000313|EMBL:AAX24116.1};
GN Synonyms=tnf-alpha-1 {ECO:0000313|RefSeq:NP_001117061.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|EMBL:AAX24116.1};
RN [1] {ECO:0000313|EMBL:AAX24116.1, ECO:0000313|RefSeq:NP_001117061.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=17566761; DOI=10.1016/j.fsi.2007.04.003;
RA Morrison R.N., Zou J., Secombes C.J., Scapigliati G., Adams M.B.,
RA Nowak B.F.;
RT "Molecular cloning and expression analysis of tumour necrosis factor-alpha
RT in amoebic gill disease (AGD)-affected Atlantic salmon (Salmo salar L.).";
RL Fish Shellfish Immunol. 23:1015-1031(2007).
RN [2] {ECO:0000313|RefSeq:NP_001117061.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the tumor necrosis factor family.
CC {ECO:0000256|ARBA:ARBA00008670}.
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DR EMBL; AY929385; AAX24116.1; -; mRNA.
DR RefSeq; NP_001117061.1; NM_001123589.1.
DR STRING; 8030.ENSSSAP00000075795; -.
DR PaxDb; 8030-ENSSSAP00000075795; -.
DR GeneID; 100136457; -.
DR KEGG; sasa:100136457; -.
DR CTD; 100136457; -.
DR OrthoDB; 2909163at2759; -.
DR Proteomes; UP000087266; Chromosome ssa05.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR CDD; cd00184; TNF; 1.
DR Gene3D; 2.60.120.40; -; 1.
DR InterPro; IPR006053; TNF.
DR InterPro; IPR006052; TNF_dom.
DR InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR PANTHER; PTHR11471:SF31; LYMPHOTOXIN-ALPHA; 1.
DR PANTHER; PTHR11471; TUMOR NECROSIS FACTOR FAMILY MEMBER; 1.
DR Pfam; PF00229; TNF; 1.
DR PRINTS; PR01234; TNECROSISFCT.
DR SMART; SM00207; TNF; 1.
DR SUPFAM; SSF49842; TNF-like; 1.
DR PROSITE; PS50049; TNF_2; 1.
PE 2: Evidence at transcript level;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT CHAIN 86..246
FT /note="tumor necrosis factor alpha-1"
FT /evidence="ECO:0000313|RefSeq:NP_001117061.1"
FT /id="PRO_5009732020"
FT TRANSMEM 33..56
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 96..246
FT /note="TNF family profile"
FT /evidence="ECO:0000259|PROSITE:PS50049"
SQ SEQUENCE 246 AA; 27111 MW; E8D176B0D2C96ABB CRC64;
MEGYAMTTGD MERGPVYMTT VTAVAEGKAS RGWLWRLCGV LLVAALCAAA ALLFAWCQHG
RLATMQDKME PQLEILIGAK DTHHTLKQIA GNAKAAIHLE GEYNPNLTAD TVQWRKDDGQ
AFSQGGFELQ GNQILIPHTG LFFVYSQASF RVKCNGPGEN TTPLSHVIWR YSDSIGVNAN
LLSGVRSVCQ RNYGDAESNI GEAWYNAVYL GAVFQLNEGD KLWTETNRLT NVEPEQGKNF
FGVFEL
//
